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Can a chill and a silver solution make dental shots less painful for kids?

NCT ID NCT07326241

Symptom relief Sponsor: Çanakkale Onsekiz Mart University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at two simple methods to help local anesthesia work better for children aged 6-12 with a condition called Molar-Incisor Hypomineralization (MIH), which makes teeth sensitive and hard to numb. Researchers will apply either silver diamine fluoride or a cold pack to the gum before giving a standard dental injection, then measure pain during treatment. The goal is to find a way to reduce discomfort and anxiety for these kids during dental procedures.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Silver diamine fluoride (SDF) and intraoral cryotherapy (cold application)
What this could lead to
If it works, this could offer a simple, low-cost way to make dental procedures less painful for children with MIH, improving their experience and cooperation.
What could go wrong
This is a small, early-stage study (75 children) that hasn't started yet. Results may not apply to all cases, and the benefits might be modest or not statistically significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 75 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 12 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children aged between 6 and 12 years. * Systemically healthy children with no medical conditions that could interfere with dental treatment. * Presence of at least one permanent first molar affected by molar-incisor hypomineralization (MIH), diagnosed according to the European Academy of Paediatric Dentistry (EAPD) criteria. * Teeth with caries lesions classified as ICDAS II codes 2, 3, 4, 5, or 6. * Children with an adequate level of cooperation to allow completion of dental treatment under clinical conditions. * Children and their parents/legal guardians who have read, understood, and signed the informed consent form and agreed to participate in the study. Exclusion Criteria: * Teeth that are not restorable. * Children with a known allergy or hypersensitivity to any materials used in the study, including local anesthetics, silver diamine fluoride, or restorative materials. * Presence of spontaneous pain, percussion sensitivity, or other signs/symptoms of pulpal pathology in the study tooth. * Children with systemic diseases or conditions that could affect pain perception, healing, or cooperation during dental treatment. * Children who are unable or unwilling to complete the clinical procedure.

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Conditions

The condition(s) this trial relates to.

Molar Hypomineralization myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Caries assessment MIH Molar incisor hypomineralization

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Mersin University, School of Dentistry

    Mersin, Turkey (Türkiye)

  • Çanakkale Onsekiz Mart University, School of Dentistry

    Çanakkale, Turkey (Türkiye)

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