Glucose intolerance

This study tests whether taking a daily probiotic (Lab4P) for 12 weeks can improve memory, thinking speed, and blood sugar control in overweight adults aged 18-40 with prediabetes (mildly high blood sugar). Seventy participants will be randomly assigned to receive either the prob…

This study tests whether eating peanuts and peanut products daily for six months can improve blood sugar, blood pressure, thinking skills, and gut health in people with prediabetes. Researchers will enroll 72 adults from diverse racial backgrounds. Participants will eat different…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and brain function in women with prediabetes. Thirty overweight women aged 20-65 will take either the blueberry powder or a placebo for six weeks. Researchers will…

This study is testing whether a healthy diet centered around beef can reduce inflammation and improve metabolic health better than a standard U.S.-style diet based on USDA guidelines. Researchers will enroll 56 adults with metabolic syndrome or pre-diabetes and assign them to one…

This study tests whether mirabegron (a bladder medication) and tadalafil (used for erectile dysfunction) can improve blood sugar control in people with prediabetes and obesity. About 96 adults will take one or both drugs or a placebo for 14 weeks. The goal is to see if these drug…

This trial tests whether taking 150 mg of grape seed extract (MegaNatural BP) daily for 6 weeks can lower blood pressure and improve heart health in adults aged 40 to 60 with elevated blood pressure and prediabetes. Researchers will measure changes in blood pressure, blood vessel…

This study tests whether personalized marketing messages and discounts can encourage people with prediabetes or type 2 diabetes to switch from refined grains to whole grains when shopping for groceries online. About 216 adults aged 45-70 from the Philadelphia area who already sho…

This study compares two exercise programs—high-intensity interval training (short bursts of fast stair climbing) and continuous endurance training (steady walking)—in adults with prediabetes. The goal is to see which approach better improves blood sugar control, body mass index, …

This small pilot study is testing whether eating Greek bottarga (grey mullet fish roe) every day can improve blood sugar, cholesterol, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 participants will compare the effects of bottarga against a dairy pro…

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps adults with prediabetes better control their blood sugar and stick to lifestyle changes compared to standard finger-prick testing. About 80 participants will be randomly assigned to use a CGM o…

This study tests whether a program called Sisters for Heart Health can help farmworker women ages 18-50 reduce stress, feel less isolated, and improve their heart health. Participants will join weekly peer support groups led by trained community health workers for 10 weeks. The s…

This study tests whether a weekly injection of dulaglutide, a GLP-1 drug used for diabetes, can improve early insulin release in adults with cystic fibrosis who have trouble processing sugar. About 30 participants will receive the drug or no drug in a crossover design. The goal i…

This study tests whether using a sit-stand desk at work can improve insulin sensitivity and reduce diabetes risk in 198 overweight, sedentary adults with prediabetes or other risk factors. Participants are randomly assigned to stand 2 or 3 hours per day at a sit-stand desk, or to…

This study looks at how fat cells work differently in normal-weight people with type 2 diabetes compared to those without diabetes. Researchers will test two drugs, pioglitazone and tirzepatide, to see if they improve insulin resistance and fat storage. About 104 adults aged 30-7…

This study tests whether taking a combination of Akkermansia muciniphila (a beneficial gut bacterium) and berberine (a plant compound) can improve insulin sensitivity in night-shift workers. 200 participants from healthcare and industry in Austria and Denmark will receive either …

This study tests whether limiting all eating to a consistent 10-hour window each day can improve blood sugar, cholesterol, and other health measures in people with metabolic syndrome or prediabetes. About 140 adults will either follow this eating schedule plus standard nutritiona…

This study tests whether keeping a consistent daily routine—like eating and sleeping at the same times—can improve blood sugar control and reduce body fat in people with pre-diabetes. Researchers will enroll 34 adults and ask half to follow a fixed schedule for 12 weeks. The goal…

This study tests several affordable oral medications—including semaglutide, empagliflozin, metformin, and pioglitazone—to see if they can reverse prediabetes, promote weight loss, and lower heart disease risk in Hispanic adults. Researchers will monitor blood sugar, body fat, and…

This study aims to identify people at increased risk of developing type 1 diabetes by testing for specific markers in the blood called autoantibodies. Children and adults aged 1 to 45 who have a family member or close friend diagnosed with type 1 diabetes before age 45 can join. …

This trial is developing an AI-powered device that listens to children's heart, breath, and bowel sounds to identify signs of common diseases like congenital heart disease, bronchopneumonia, and abdominal issues. It will involve 30,000 children aged 0-18, some with these conditio…

This trial tests whether two natural supplements—quercetin (from foods like apples and onions) and coenzyme Q10 (a substance your body makes)—can reduce inflammation and improve metabolic health in older adults. Over 12 weeks, participants aged 50 to 75 who are sedentary will tak…

This phase II trial tests whether a special form of nicotinic acid (a B vitamin) can reverse prediabetes and prevent type 2 diabetes. About 390 adults with prediabetes will take either a low or high dose of the drug or a placebo daily for 26 weeks, along with lifestyle advice. Th…

This study tests whether the drug semaglutide can prevent type 2 diabetes in women who had gestational diabetes and now have high blood sugar after pregnancy. About 252 women will receive either semaglutide or a placebo for several months. The goal is to see if the drug lowers th…

This pilot study tests whether a single, personalized conversation with a healthcare team member or a brief message through a patient portal can encourage adults with prediabetes to take action—like joining a diabetes prevention program or starting medication. Researchers will co…

This study tests whether ursodeoxycholic acid (UDCA), a drug used for bile duct problems, can stop statins from raising blood sugar. 128 adults with high cholesterol but normal blood sugar will take either UDCA or a placebo alongside atorvastatin for 6 months. Researchers will tr…

This study tests a 3-year lifestyle program for 1,305 Brazilian adults at high risk for type 2 diabetes. The program combines in-person and online counseling on diet, exercise, sleep, and stress. Researchers will track who develops diabetes and measure weight, blood sugar, and qu…

This study tests whether a natural bile acid called 7-Ketolithocholic Acid, taken as a supplement, can lower blood sugar levels in 100 adults with prediabetes. Participants will also follow a healthy diet and exercise plan. The goal is to see if this supplement can help prevent o…

This study looks at whether drinking regular milk can lower the risk of type 2 diabetes in people with lactose intolerance who also have pre-diabetes. Researchers will compare regular milk to lactose-free milk over 12 weeks in 40 adults. They will measure changes in gut bacteria,…

This study tests whether a diet tailored to a person's unique metabolism (called a 'metabotype') can prevent type 2 diabetes better than standard healthy eating advice. Overweight or obese adults at risk for diabetes will follow either a personalized or standard diet for 12 month…

This study tests whether adding reminders to electronic medical records helps doctors better manage pre-diabetes. About 6000 adults with pre-diabetes will take part. Some clinics will use the reminders, others won't. The goal is to see if the prompts lead to more blood tests, ref…

This study looks at whether eating a small handful of almonds (about 18 grams) 30 minutes before a meal can reduce the rise in blood sugar after eating. Researchers will test 25 adults with prediabetes, comparing blood sugar levels after meals with and without almonds. They also …

This study follows people who previously took part in type 1 diabetes trials to see how long their bodies continue to produce insulin. Researchers will also look at how immune system changes relate to insulin production. The goal is to gather information that could lead to better…

This study tests whether people with prediabetes and obesity change their eating and activity habits when they can see their glucose levels in real time versus when the data is hidden. Thirty-four adults will wear a continuous glucose monitor during both an open and a blinded pha…

Researchers are building a large, diverse group of adults with varying body sizes, ethnicities, and diabetes risk. They will collect blood, stool, and fat tissue samples to study how obesity relates to diabetes and other health issues. The goal is to create a rich resource for fu…

This study looks at why people with pre-diabetes or type 2 diabetes tire more quickly during leg exercises. Researchers will test a special low-load resistance training program, sometimes with blood flow restriction, to see if it improves muscle strength, blood flow, and energy u…

This study will screen 7,000 adults in China who are at high risk for diabetes but do not yet have it. Researchers will track blood sugar changes, eye health, and bone density over time. The goal is to find better ways to prevent diabetes and create a new model for managing high-…

This study looks at what happens when adults with metabolic syndrome stop taking their usual metformin medication for 14 days. Researchers want to see if a short break affects insulin sensitivity, blood sugar levels, and other health markers. Participants will be randomly assigne…

This study looks at whether giving tube feedings during the day instead of at night can improve sleep and body rhythms in patients recovering from heart surgery in the ICU. Researchers will monitor sleep patterns and body temperature in 30 adults. The goal is to learn if simple c…

This study looks at how a person's natural sleep pattern (chronotype) affects their body's ability to handle sugar. Researchers will compare blood sugar and insulin responses in 70 overweight young adults (ages 18-23) who are either night owls or early birds. Participants will ta…

This study looks at whether reducing ultra-processed foods (like chips and sugary drinks) can improve blood sugar levels in healthy Korean adults aged 20-39. Participants will wear a continuous glucose monitor and report their diet for 10 days before and after receiving dietary c…

This study uses the FreeStyle Libre 3 continuous glucose monitor to record blood sugar levels in 2,000 adults, both with and without prediabetes. The goal is to identify patterns that could help spot prediabetes earlier. Participants wear the monitor for a period while going abou…

This study looks at whether routine blood sugar tests (like fasting glucose and HbA1c) can predict gestational diabetes in pregnant women who have had bariatric surgery and cannot tolerate the standard sugary drink test. Researchers will follow 84 women throughout pregnancy to se…

This study looks at how different amounts of supervised indoor cycling change gut bacteria and related substances in healthy men aged 18 to 45. Participants will be placed into one of three groups: no structured training, moderate cycling, or high-load cycling. Researchers will m…

This study tests whether wearing a continuous glucose monitor (CGM) helps adults with prediabetes improve their diet and physical activity compared to standard health coaching. 76 participants from a Singapore polyclinic will be randomly assigned to receive either a CGM plus coac…

This study looks at how a hormone called GLP-1, made in the pancreas, helps control blood sugar in people with prediabetes. Researchers will give a drug that blocks GLP-1 to see how it changes insulin and glucagon release. The goal is to understand why some people with prediabete…

This study aims to understand how a person's weight and blood sugar levels influence the activity of genes in tissues that process sugar and fat. Researchers will collect tissue samples from 20,000 adults undergoing abdominal surgery. The goal is to learn more about the link betw…