Functional gastric disease

This phase 2 trial tests the drug pasireotide in 93 adults who experience severe low blood sugar after weight-loss surgery. Participants receive either the drug or a placebo for 12 weeks, then all can receive the drug for 36 more weeks. The goal is to see if pasireotide can stabi…

Upper abdominal pain often comes from functional dyspepsia, irritable bowel syndrome, or uncomplicated gallstones. These conditions overlap and many patients do not know that tests and surgery may not help. Researchers are testing a personalized web-based education tool that expl…

This study tests a drug called avexitide in 75 adults who have dangerous low blood sugar episodes after gastric bypass surgery. Participants receive either the drug or a placebo for 16 weeks to see if it reduces severe sugar crashes. The goal is to control this long-term conditio…

This trial tests whether a daily fibre supplement, taken for 8 weeks, can improve gut health and ease symptoms like bloating, indigestion, and irregular bowel movements. Fifty adults who experience digestive discomfort will take the supplement each morning and answer questionnair…

This trial tests whether a procedure called per-oral pyloromyotomy (POP), which relaxes the stomach's outlet muscle, can improve blood sugar control in people with diabetes and gastroparesis (delayed stomach emptying). About 40 adults with poorly controlled diabetes (HbA1c above …

This study tests two different drug combinations to treat Helicobacter pylori, a stomach bacteria that can cause indigestion. About 66 adults with dyspepsia will receive either a triple therapy (amoxicillin, clarithromycin, esomeprazole) or a quadruple therapy (bismuth, metronida…

This study tests two procedures—G-POEM and a gastric electrical stimulator—for people with severe gastroparesis (stomach paralysis) that hasn't improved with medication. Forty adults will be randomly assigned to one of two groups to compare safety and symptom relief. The goal is …

This study is testing a new device called Gastric Alimetry that records the stomach's electrical activity through electrodes placed on the belly. Researchers want to see if it can reliably detect abnormal stomach rhythms in people with conditions like gastroparesis and functional…

This trial tests whether injecting botulinum toxin into the pylorus—the muscle at the stomach's exit—can help children aged 30 days to 18 years who struggle with chronic nausea, vomiting, or feeding intolerance. Participants receive the injection during an upper endoscopy, and re…

This study tests a drug called tradipitant for people with functional dyspepsia, a condition causing stomach pain and fullness after eating. Researchers will compare the drug to a placebo in 60 adults to see if it improves stomach function and reduces symptoms. The goal is to fin…

This study tests a procedure called per-oral pyloromyotomy (POP) to see if it helps people with gastroparesis, a condition where the stomach empties too slowly. About 100 adults who have not improved with standard treatment will be randomly assigned to either the real procedure o…

This study tests whether a small device worn behind the ear, which sends mild electrical pulses to nerves, can reduce abdominal pain in adults with gastroparesis-like symptoms (slow stomach emptying). About 140 participants will be randomly assigned to receive either the active d…

This pilot study from Mayo Clinic tests whether using a virtual reality headset can safely ease symptoms of gastroparesis, a condition where the stomach empties too slowly. Thirty adults with gastroparesis will try VR programs with games, meditation, and relaxation exercises. The…

This program allows people aged 12 and older with severe stomach or gut problems, like gastroparesis, to try domperidone when standard treatments have failed. The goal is to ease symptoms such as nausea, vomiting, and severe indigestion. The drug is not FDA-approved but is availa…

This study compares two types of weight-loss surgery—sleeve gastrectomy alone versus sleeve gastrectomy with transit bipartition—to see which leads to fewer cases of dumping syndrome (nausea, diarrhea, dizziness after eating) and better quality of life. Researchers will follow 20…

This study gives 20 healthy adults drinks containing sucrose (table sugar), glucose, fructose, or plain water, then measures how their bodies respond. Researchers track gut hormones, blood sugar, digestion speed, and other health markers. The goal is to understand the unique effe…

This study is creating a registry of 500 adults with functional GI disorders like IBS and chronic constipation. Researchers will collect medical data, diet and lifestyle questionnaires, and biological samples to explore genetic, microbial, and environmental factors. The goal is t…

This study looks at how GLP-1 receptor agonists (like Ozempic or Wegovy) affect how fast the stomach empties before surgery. These drugs are used for weight loss and diabetes, but they slow stomach emptying, which could raise the risk of food or liquid entering the lungs during a…

This study looks at 200 people with ongoing stomach discomfort (functional dyspepsia) to find out how often they have small intestinal bacterial overgrowth (SIBO). Researchers will compare two methods—growing bacteria in a lab and DNA testing—to identify which germs are present. …

This study uses MRI scans to look at the brain and upper digestive tract in people with gastroparesis and healthy volunteers. The goal is to better understand how the brain and gut interact in this condition. Researchers will compare stomach movements before and after meals. This…

This study creates a registry of people with gastroparesis—a condition where the stomach empties too slowly, causing nausea, vomiting, and pain—who have received a gastric electrical stimulation (GES) device. The goal is to collect long-term data to help researchers understand ho…

This study looks at how diet, genetics, and gut bacteria work together to cause digestive problems like IBS, IBD, and celiac disease. Researchers will follow about 4,000 adults with and without these conditions to find patterns. The goal is to understand why some people get sick …

This study follows 2,500 people with gastroesophageal reflux disease (GERD) to compare how well medications and surgery work over time. Researchers will track quality of life, heartburn symptoms, and patient satisfaction. The goal is to identify who benefits most from each treatm…

This study tests whether electrically stimulating a nerve in the ear can reach the internal vagus nerve, which controls stomach function. Researchers will measure nerve signals and stomach activity in 131 healthy volunteers and people with gastroparesis. The goal is to see if thi…

This study looks at how a device that electrically stimulates the stomach (gastric electrical stimulation) affects the vagus nerve and heart in people with gastroparesis, a condition where the stomach empties slowly. Researchers will measure heart rate variability and hormone lev…

This study looks at how the vagus nerve works in people with gastroparesis (stomach paralysis) who have a gastric electrical stimulator implanted. Researchers will use a non-invasive electrode patch on the neck to measure nerve signals and see if they relate to symptom relief. Th…

This study looks at whether cold or warm liquid food given through a tube affects how fast the stomach empties in adult intensive care patients. Researchers will measure stomach volume over time and check for issues like vomiting or diarrhea. The goal is to find out which tempera…

This study looks at how different doses of glucagon, a natural hormone that raises blood sugar, affect people who have low blood sugar after weight-loss surgery. Researchers will give 28 participants several doses of glucagon and measure their blood sugar and hormone levels. The …

This study aimed to find out if two tests—EndoFLIP and antroduodenal manometry—could predict which patients with severe gastroparesis would benefit from a procedure called G-POEM. The plan was to measure stomach muscle activity and pressure before the procedure. However, the stud…