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Ear zaps aim to tame stomach troubles

NCT ID NCT06491758

Knowledge-focused Sponsor: Indiana University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether electrically stimulating a nerve in the ear can reach the internal vagus nerve, which controls stomach function. Researchers will measure nerve signals and stomach activity in 131 healthy volunteers and people with gastroparesis. The goal is to see if this ear stimulation method could one day treat nausea, vomiting, and other stomach issues.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
electrical stimulation of the ear
What this could lead to
If successful, this could lead to a non-invasive way to treat nausea, vomiting, and stomach disorders by stimulating the vagus nerve through the ear.
What could go wrong
This is an early-phase study focused on measuring nerve signals, not on treatment outcomes. It may not lead to a practical therapy, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

131 people

The number who actually took part.

Started

Jun 2020

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria healthy volunteers * Healthy volunteers with no gastric symptoms or conditions (except due to COVID 19) * Aged 18-80 years * Willing to have electrodes placed in the external ear (ABVN arm) * Willing to perform vagal activity maneuver (Vagal arm) * Willing to have 1 tablespoon (15 ml) of blood drawn at 3 time points Inclusion Criteria gastroparesis subjects * Gastroparesis subjects with a confirmed diagnosis of gastroparesis from a GI physician * Have a formal diagnosis of gastroparesis or are seeing the GI physician for symptoms related to gastroparesis * Aged 18-80 years * Willing to have electrodes placed in the external ear (ABVN arm) * Willing to perform vagal activity maneuver (Vagal arm) * Willing to have 1 tablespoon (15 ml) of blood drawn at 3 time points Exclusion Criteria: * Unable to provide consent * Pregnant females * Prisoners

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Conditions

The condition(s) this trial relates to.

gastroparesis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gastroparesis

Contacts and locations

Locations

  • Indiana University

    Indianapolis, Indiana, 46202, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.