Study tests glucagon doses for Post-Surgery low blood sugar
NCT ID NCT06986603
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how different doses of glucagon, a natural hormone that raises blood sugar, affect people who have low blood sugar after weight-loss surgery. Researchers will give 28 participants several doses of glucagon and measure their blood sugar and hormone levels. The goal is to understand how the body responds, not to test a new treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 28 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2024
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: 1. Age 18-70 years of age, inclusive, at screening. 2. Willingness to provide informed consent and follow all study procedures, including attending all scheduled visits. 3. Males or females diagnosed with ongoing PBH, at least 2 years following Roux-en-Y gastric bypass (RYGB), with documented episodes of hypoglycemia, and history of fulfillment of Whipple's triad. Exclusion criteria: 1. Documented hypoglycemia occurring only in the fasting state (\>12 hours fast); 2. Current diabetes, defined as hemoglobin A1c \>6.5% or use of diabetes medications, except for acarbose or miglitol; 3. Chronic kidney disease stage 4 or 5 (including end-stage renal disease); 4. Hepatic disease, including serum ALT or AST greater than 2 times the upper limit of normal; hepatic synthetic insufficiency as defined as serum albumin \< 3.0 g/dL; or serum bilirubin \> 2.0; 5. Congestive heart failure, NYHA class II, III or IV; 6. History of myocardial infarction, unstable angina or revascularization within the past 6 months. 7. Two or more risk factors for coronary artery disease including diabetes, uncontrolled hypertension, uncontrolled hyperlipidemia, and active tobacco use. 8. History of recurrent syncope (unrelated to hypoglycemia) or active diagnosis of a cardiac arrhythmia; 9. Current administration of β-blocker therapy; 10. History of a cerebrovascular accident; 11. Seizure disorder (other than with suspect or documented hypoglycemia); 12. Active treatment with long-acting (LAR) octreotide or pasireotide; 13. Active malignancy, except basal cell or squamous cell skin cancers; 14. Personal or family history of pheochromocytoma or disorder with increased risk of pheochromocytoma (MEN 2, neurofibromatosis, or Von Hippel-Lindau disease); 15. Known insulinoma; 16. Major surgical operation within 30 days prior to screening; 17. Clinically significant anemia as defined as a hematocrit \< 33%; 18. Bleeding disorder, treatment with warfarin, or platelet count \<50,000; 19. Blood donation (1 pint of whole blood) within the past 2 months; 20. Active alcohol abuse or substance abuse; 21. Current administration of oral or parenteral corticosteroids; 22. Pregnancy and/ or lactation: For women of childbearing potential: there is a requirement for a negative urine pregnancy test before any procedures. 23. Not enrolled in another study that uses an investigational drug for this condition. \- Exclusion Criteria: \-
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Joslin Diabetes Center
Boston, Massachusetts, 02215, United States
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University of Alabama
Birmingham, Alabama, 35233, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Brain scans may predict who is most at risk for dangerous low blood sugar
- Mapping the hormone behind Post-Surgery blood sugar crashes
- Can collagen supplements help preserve muscle after Weight-Loss surgery?
- Blood markers may predict muscle loss after Weight-Loss surgery
- Can big data reveal why some patients suffer after Weight-Loss surgery?
- Ancient breathing technique could supercharge Post-Surgery fitness