Dystonic disorder

This study tests whether changing the way deep brain stimulation is delivered can improve tremor control in people with essential tremor who don't get enough relief from their current settings. Researchers will use computer models and brain scans to see how the new stimulation pa…

This trial compares two approaches to voice care after surgery for benign vocal cord lesions like polyps or cysts. One group stays completely silent for five days, while the other uses soft, low-effort whispering. Both groups then receive the same voice therapy. The study measure…

This pilot trial tested whether taking oral zinc every day for 6 months is safe and doable for people with GNAO1 disorders, a rare genetic condition that causes movement problems, seizures, and developmental delays. 13 participants aged 6 months to 30 years took zinc acetate. The…

This early-phase trial tested whether injecting a patient's own stem cells into scarred vocal folds could safely improve severe hoarseness. Nine adults with untreatable voice problems received the stem cell injection during surgery. Researchers monitored side effects and voice fu…

This study tested a new keyhole surgery (laparoscopic vaginorectopexy) in 25 women with multiple pelvic organ prolapses causing bowel problems. Researchers checked how well the surgery worked by looking at prolapse recurrence, bowel function, and quality of life up to 12 months a…

This study tested whether a new device called EndoFLIP can better diagnose anismus, a condition where the anal muscles don't relax properly during bowel movements, causing severe constipation. Researchers measured anal stretchiness in 61 patients with chronic constipation and com…

This study tested a small clip attached to the breathing tube used during anesthesia to see if it could prevent sore throat, voice changes, and trouble swallowing after surgery. 100 adults having surgery with general anesthesia took part. The clip is designed to reduce pressure o…

This trial tests whether botulinum toxin type A, commonly known as Botox, can ease the involuntary muscle contractions of oromandibular dystonia, a condition that affects the jaw, tongue, and face. Researchers inject the toxin into specific muscles using electromyography (EMG) to…

This trial tests whether taking zinc supplements for five days before a Botox injection into the vocal cords can extend the treatment's benefits for people with spasmodic dysphonia, a condition that causes involuntary voice spasms. Participants will take a 50 mg zinc gluconate pi…

This study tested a small vibrating device worn on the neck to see if it could make speaking easier for people with spasmodic dysphonia, a rare voice disorder. Forty participants used the device at home for 20 minutes a day over 8 weeks. They reported how much effort it took to s…

This study tests whether adding aerobic exercise to standard lymphedema therapy (complex decongestive physiotherapy) can improve walking, balance, leg strength, and daily function. Twenty-four adults with bilateral lower limb lymphedema will be randomly assigned to either standar…

This early-stage trial tested a new oral drug called MTR-601 in 89 healthy adults to see if it is safe and how the body processes it. The drug aims to reduce muscle stiffness and spasms, which could help people with conditions like cerebral palsy, multiple sclerosis, or stroke. S…

This study tested a new type of botulinum toxin injection (DAXI) for people with adductor spasmodic dysphonia, a condition that causes the voice to spasm and sound strained. 22 adults who had previously been helped by standard Botox injections received a single DAXI injection int…

This study looked at the safety and immune response of MYOBLOC (botulinum toxin type B) injections in 502 adults with cervical dystonia, a condition causing painful neck muscle spasms. Participants received injections and were monitored for about 12 weeks. The goal was to see if …

This completed study tested whether a noninvasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could help people with focal hand dystonia, a condition that causes hand cramping during tasks like writing. Twelve participants received rTMS …

This completed trial tested whether a nerve stimulation treatment called PTNS can help children aged 8-18 with constipation caused by pelvic floor dyssynergia. Forty participants received either real PTNS or a sham (fake) treatment to see if it improves bowel function. The goal i…

This study tested a wearable compression device called Dayspring for people with lymphedema in one leg. 24 adults used the device daily for 3 months. Researchers measured changes in leg swelling and quality of life to see if the device was safe and helpful.

This study looked at whether applying an ice compress to the neck before botulinum toxin injections can reduce pain for people with spasmodic dysphonia, a chronic voice disorder. 116 adults received either ice or no ice before their injection and then filled out a pain questionna…

This study compared two types of exercises for adults with long-term neck pain. After six weeks, those who did cervical stabilization exercises had greater improvements in pain, daily function, head posture, and voice efficiency than those who did traditional exercises. Both grou…

This study tested whether a single dose of sodium oxybate can improve voice symptoms in people with spasmodic dysphonia and voice tremor. 117 adults received the drug or a placebo, and researchers measured changes in symptom severity. The goal was to see if the drug could mimic t…

This study tested two non-drug treatments for paradoxical vocal fold motion (PVFM), a condition where vocal cords close when they should open, causing shortness of breath. Fifty-one adults were randomly assigned to either biofeedback (watching their breathing on a screen) or lary…

This study tested an experimental pill called dipraglurant in 15 people with blepharospasm, a condition causing uncontrollable eyelid spasms. Participants received either 50 mg, 100 mg, or a placebo to see if the drug is safe and can reduce spasm severity and frequency. The goal …

This study tested whether amifampridine can reduce temporary voice weakness and breathiness that often occurs in the first few weeks after Botox injections for spasmodic dysphonia (a voice disorder). 18 adults who regularly get Botox for this condition took part. The goal was to …

This study looked at 85 people with tremor conditions like Parkinson's disease, essential tremor, and dystonia, plus healthy volunteers. Researchers used tests like brain scans, electrical recordings, and movement tasks to learn how the brain controls movement and what goes wrong…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study used PET and MRI brain scans to measure how a brain chemical called acetylcholine works in people with dystonia, a condition that causes involuntary muscle twisting. Researchers compared 31 adults with cervical or DYT1 dystonia to healthy volunteers. The goal was to be…

This study tracks how often swallowing difficulties (dysphagia) and voice changes (dysphonia) happen after anterior cervical spine surgery — a common procedure to treat a narrow spinal canal. Researchers will follow 36 patients for one year after surgery, using questionnaires and…

This study looks at people with chronic constipation to see if a specific muscle problem called puborectalis syndrome can be better identified using three different tests: defecography, high-resolution anorectal manometry, and pelvic floor ultrasound. Researchers will compare res…

This study looks at whether people with dyssynergic defecation—a condition where the pelvic muscles don't relax properly during bowel movements—are more likely to have psychiatric disorders like anxiety or depression. Researchers will compare 148 patients to healthy volunteers us…

This study tests a device that synchronizes two types of brain stimulation — deep brain stimulation (DBS) and transcranial alternating current stimulation (tACS) — in people with Parkinson's disease. Only 2 participants will be enrolled to see if the device can lock the timing of…

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This study looked at how alcohol affects tremors in people with essential tremor, dystonia, and Parkinson's disease. 45 participants received either an alcoholic drink or a non-alcoholic placebo on separate days. Researchers measured tremor changes using a motion sensor and clini…

This study tested whether a gentle, non-invasive brain stimulation technique called tDCS, applied over the cerebellum, can change brain activity and reduce symptoms in people with cervical dystonia (neck muscle spasms). Fifteen participants received real and sham (fake) stimulati…

This study looked at how a specific brain chemical system (cholinergic) might be involved in dystonia, a condition causing muscle spasms and abnormal postures. Researchers used PET scans to measure chemical activity in the brains of 40 adults with a genetic form of dystonia (DYT1…

This completed study looked at 60 people with obstructed defecation, a severe form of constipation. Researchers compared how well a noninvasive nerve stimulation treatment worked in obese versus non-obese participants. The goal was to see if body weight changes the treatment's ab…

This study looked at 102 adults with dystonia, a condition causing involuntary muscle contractions. Researchers used questionnaires and brain wave recordings to assess memory, attention, mood, and decision-making. The goal was to better understand the non-motor symptoms of dyston…

This study tested how accurately a robot system called Neurolocate helps place electrodes in the brain during deep brain stimulation surgery. It involved 18 adults with Parkinson's disease, dystonia, or tremor. The goal was to see if the robot could improve precision, reduce surg…

This completed study looked at how the cerebellum is involved in movement, thinking, and emotions in people with myoclonus dystonia, a rare movement disorder. Researchers used MRI scans to compare brain activity in 47 participants while they performed small tasks. The goal was to…

This study looked at how voice and swallowing change after a second neck spine surgery. Two hundred patients had their vocal cords and swallowing checked before and about three weeks after surgery. They also filled out a short quality-of-life survey. The goal was to better unders…

This study looked at how cervical dystonia (neck muscle spasms) and blepharospasm (eye muscle spasms) affect walking. Researchers measured gait in 40 participants before and after botulinum toxin treatment to see if it improves walking patterns. The goal was to better understand …

This study looked at how people with cervical or myoclonus dystonia perceive their own actions, known as the 'sense of agency.' Researchers used computer tasks and brain scans to measure how accurately participants felt in control of their movements. The goal was to link these fe…

This study looked at whether giving patients online educational modules before starting voice therapy helps them stay engaged and attend more sessions. Researchers enrolled 42 adults with voice problems (dysphonia) who were recommended for voice therapy. The goal was to see if th…

This study looked at how two brain regions—the cerebellum and striatum—communicate in people with dystonia caused by ADCY5 or PRRT2 gene mutations. Researchers used MRI scans and mild brain stimulation to compare brain activity among patients and healthy volunteers. The goal was …

This completed study tested deep brain stimulation (DBS) in the cerebellum's dentate nucleus to treat movement disorders like tremor, dystonia, and ataxia. Researchers used advanced MRI and electrical recordings to guide electrode placement in 20 adults. The goal was to see if th…

This study looked at a questionnaire designed to measure how leg swelling (lymphedema) affects daily life. Researchers tested a French version for accuracy and checked if the Dutch version can track changes over time. Over 450 people with leg lymphedema filled out the questionnai…

This study tested a wrist-worn device called the Personal KinetiGraph (PKG) to see if it can accurately measure movement problems in people with Parkinson's disease. Nineteen participants wore the device while researchers compared its readings to standard clinical tests and video…

This completed study used eye-tracking to explore how the brain adapts movements in people with dystonia, essential tremor, or Parkinson disease. Researchers measured eye movements before and after a task to look for signs of cerebellar dysfunction. The study included 14 particip…

This study investigates how the cerebellum influences brain plasticity in people with dystonia, a movement disorder, and in healthy volunteers. Researchers use non-invasive brain stimulation (TMS) to temporarily change cerebellar activity and measure its effects on brain plastici…