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Zapping the cerebellum: new hope for tremor and dystonia?

NCT ID NCT07231302

Knowledge-focused Sponsor: Kleber Paiva Duarte Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study tested deep brain stimulation (DBS) in the cerebellum's dentate nucleus to treat movement disorders like tremor, dystonia, and ataxia. Researchers used advanced MRI and electrical recordings to guide electrode placement in 20 adults. The goal was to see if this technique could improve symptoms when medication fails.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
deep brain stimulation (electrical stimulation of the dentate nucleus)
What this could lead to
If successful, this could help refine surgical targeting for deep brain stimulation, potentially improving treatment for movement disorders like tremor and dystonia.
What could go wrong
This was a small, completed study with only 20 participants, so results may not apply to everyone. The approach is still experimental and requires further validation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

20 people

The number who actually took part.

Started

Apr 2016

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with dystonia, ataxia or tremor

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 or older 2. Clinical diagnosis of cerebellar syndrome resulting from stroke and spinocerebellar degeneration, intractable tremor, primary or secondary dystonia, refractory to drug and physiotherapy treatment; 3. Signed the term of free and informed consent Exclusion Criteria: 1. Age under 18 years; 2. Presence of severe anatomical deformities in the cerebellum and/or brainstem;

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Conditions

The condition(s) this trial relates to.

acquired torsion dystonia atactic disorder Ataxia cerebellar ataxia choreatic disease Dystonia dystonic disorder essential tremor idiopathic torsion dystonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ataxia - other Choreatic disorder Deep brain stimulation surgery Dystonia disorder Tremor, essential

More trials for these conditions

Other studies related to the condition(s) this trial covers.