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Brain stimulation study probes Cerebellum's role in dystonia

NCT ID NCT01272154

Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study investigates how the cerebellum influences brain plasticity in people with dystonia, a movement disorder, and in healthy volunteers. Researchers use non-invasive brain stimulation (TMS) to temporarily change cerebellar activity and measure its effects on brain plasticity and dystonia symptoms. The goal is to better understand the cerebellum's role in the condition, which could inform future treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial magnetic stimulation
What this could lead to
If successful, this could clarify the role of the cerebellum in dystonia and point toward new brain-stimulation treatments.
What could go wrong
This is a small, early-stage study focused on understanding brain mechanisms, not testing a treatment. Results may not lead to direct therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

120 people

The number who actually took part.

Started

Jan 2011

Finished

Oct 2012

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria All subjects * Age \>18 years and \< 70 years * Normal physical and neurological examination, except for dystonia (when present) * No treatment with botulinum toxin during the last three months * No treatment altering the cortical excitability * Agreement to use a medically acceptable method of contraception throughout the study for female of childbearing potential Primary focal dystonia group * Patients with cervical and/or upper limb dystonia * No cause of secondary dystonia Secondary dystonia group • Cervical dystonia and/or upper limb dystonia History of perinatal anoxia Exclusion criteria * MMS ≤ 24/30 * Current neurological or psychiatric illness other than dystonia. * Individual who is on medication which is known to lower seizure threshold (see lists above), or who has a pacemaker, an implanted medical pump, a metal plate, a metal plate or metal object in the skull or eye (for example after brain surgery) will be excluded * Uncontrollable medical problems not related to dystonia such as; cardiopulmonary disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer, or renal disease * Previous history of seizure(s) or current active epilepsy * Pregnancy, breast feeding women and women who are of childbearing age and not practicing adequate birth control. * Patients legally protected * Patients who are not enrolled at social security

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Conditions

The condition(s) this trial relates to.

acquired torsion dystonia cerebral palsy Dystonia dystonic disorder focal dystonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dystonia

Contacts and locations

Locations

  • Hpôpital Pitié Sapétrière - U 975 Plate forme " Pole Exploration de l'homme : Gait, Equilibrium, Posture, and Movement "

    Paris, 75013, France

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