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Can brain stimulation sharpen Decision-Making in Parkinson's?

NCT ID NCT01845883

Knowledge-focused Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This study investigates how the brain makes decisions when visual information is uncertain, focusing on the roles of the basal ganglia and cerebellum. Researchers will compare healthy adults with patients who have Parkinson's disease, dystonia, or cerebellar damage, and will test whether deep brain stimulation (DBS) or certain medications affect decision-making performance. Participants perform a visual task while their brain activity is influenced by DBS (on/off) or medication status. The goal is to understand the neural mechanisms behind perceptual choices under uncertainty, which could inform future treatments for these conditions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Deep Brain Stimulation (DBS) - a procedure that uses implanted electrodes to deliver electrical pulses to specific brain areas.
What this could lead to
If successful, this research could clarify how the basal ganglia and cerebellum support decision-making under uncertainty, potentially guiding future treatments for Parkinson's disease, dystonia, and ataxia.
What could go wrong
This is an early-stage observational study with a small number of participants, so findings may not apply broadly. DBS carries risks such as infection, bleeding, or device-related complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Apr 2013

Expected to finish

Dec 2016

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Group 1 - Age and Sex matched healthy controls: * Age 18-80 Years Group 2 - Patients with Parkinson's Disease - No DBS: * "on meds" and "off meds" (tested in separate sessions) - total of 2 sessions * Age 45-80 Years * Unified PD rating scale (UPDRS) * Mini mental health Status (MMHS) Group 3 - Patients with Parkinson's Disease already consented for DBS (STN): * Age 45-80 Years * Unified PD rating scale (UPDRS) * Mini mental health Status (MMHS) Group 4 - Patients with Parkinson's Disease already consented for DBS (GPi): * Age 45-80 Years * Unified PD rating scale (UPDRS) * Mini mental health Status (MMHS) Group 5 - Patients with Cervical Dystonia - No DBS * Age 30-80 years * Fahn-Marsden dystonia rating scale (FMDRS) * Mini mental health Status (MMHS) Group 6 - Patients with Generalized Dystonia (Ach) - No DBS: * Age 30-80 years * Fahn-Marsden dystonia rating scale (FMDRS) * Mini mental health Status (MMHS) Group 7 - Patients with Dystonia already consented for DBS (GPi): * Age 30-80 years * Fahn-Marsden dystonia rating scale (FMDRS) * Mini mental health Status (MMHS) Group 8 - Patients Cerebellar Stroke * Age 30-80 Years * Routine neuro exam * Mini mental health Status (MMHS) Group 9 - Patients Cerebellar Ataxia * Age 30-80 Years * Routine neuro exam * Mini mental health Status (MMHS) Exclusion Criteria: * Visual impairment or ocular motility disorder Inability to sit for the 30 minute task plus 20-30 minute instruction time, setup, and wait time. For Group 1 (Age Sex Matched Controls), there will additional exclusion criteria of other neurological disease and drug use

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Conditions

The condition(s) this trial relates to.

Ataxia cerebellar ataxia cervical dystonia Dystonia dystonic disorder generalized dystonia Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ataxia Dystonia Parkinson's disease

Contacts and locations

Locations

  • Neuroscience Research Building

    Los Angeles, California, 90095, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.