DYSTONIA

This study follows 1,000 people with Parkinson's disease, essential tremor, or dystonia who receive an Abbott deep brain stimulation (DBS) system. Researchers will measure changes in movement symptoms and track any serious side effects over five years. The goal is to confirm the …

This study tests deep brain stimulation (DBS) surgery for people with Parkinson's disease, essential tremor, or dystonia whose symptoms are not well controlled by medication. A small device, like a pacemaker, is placed in the chest and sends electrical signals to specific brain a…

This study tests if deep brain stimulation (DBS) can help reduce muscle stiffness and improve movement in people who had a stroke 9 to 36 months ago. Twelve participants will have an electrode implanted in the cerebellum and try three different stimulation frequencies during reha…

This study follows 300 people with dystonia who receive a commercially approved deep brain stimulation system. The goal is to see how well the treatment reduces symptoms like muscle spasms and abnormal postures in everyday medical practice. Participants must be at least 7 years o…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose dystonia, a movement disorder. The goal is to see if the AI can correctly identify dystonia and reduce the time it takes to get a diagnosis. About 1,000 people w…

This study tests whether an experimental drug called VIM0423 can reduce muscle spasms and improve daily life for people with isolated dystonia, a movement disorder. About 100 adults aged 18 to 65 with dystonia affecting at least two body areas will receive either the drug or a pl…

This study looks at brain activity related to speech in people with Parkinson's disease, essential tremor, or dystonia. Participants are already scheduled for deep brain stimulation (DBS) surgery. Researchers will record brain signals during speech tasks to better understand how …

This study is creating a shared database of information from up to 100 children who have had or will have deep brain stimulation (DBS) for conditions like dystonia, epilepsy, or Tourette syndrome. By combining data from multiple hospitals, researchers hope to learn which children…

This study looks at whether analyzing how people with dystonia walk before deep brain stimulation (DBS) surgery can predict how well the surgery will work. About 50 adults scheduled for DBS will wear small movement sensors while walking. Researchers will then compare walking patt…

This study looks at how the brain's motor network works in children with dystonia, a movement disorder. Researchers will use noninvasive tests like EEG to measure brain activity at rest and during simple tasks. The goal is to learn how the brain changes over time and how deep bra…

This study tests whether recording brain signals from the implanted DBS device can help doctors find the best stimulation settings faster for people with dystonia. About 25 adults who are already scheduled for DBS surgery will take part. Researchers will compare standard programm…

This study aims to find out how common functional neurological disorders are in people who already have a movement disorder like Parkinson's disease, tremor, or dystonia. Researchers will examine 216 participants with neurological exams, thinking tests, and questionnaires. The go…

This study aims to understand how deep brain stimulation (DBS) changes brain activity in people with dystonia, a movement disorder. Researchers will use brain scans and electrical recordings from 15 participants who already have DBS implants. The goal is to learn more about the d…

This study looks back at the medical records of up to 5,000 people who have or are eligible for deep brain stimulation (DBS) to treat Parkinson's disease, essential tremor, or dystonia. Researchers want to see how well DBS improves symptoms over time in everyday medical practice.…

This study is collecting information from 200 people with Parkinson's disease, dystonia, essential tremor, or other movement disorders who are scheduled to receive a standard radiofrequency (RF) ablation treatment. The goal is to see how the procedure affects patients' quality of…

This study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Researchers will monitor brain activity and sleep quality in 64 adults who already have or will get a DBS device. The goal is to understand which brain pathways control sleep pr…

This study looks at how deep brain stimulation (DBS) — a treatment already used for movement disorders — affects voice and speech in people with laryngeal dystonia or voice tremor. Researchers will record brain signals during surgery and measure voice changes afterward. The goal …

This study looks at how alcohol affects tremors in people with essential tremor, dystonia, and Parkinson's disease. 45 participants will receive either an alcoholic drink or a non-alcoholic placebo on two separate days. Researchers will measure tremor changes using a device and c…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse disorder. Researchers will measure brain responses and any changes in movemen…

This study tracks brain activity in 25 people with dystonia who are getting deep brain stimulation (DBS). Researchers want to find brain signals that show how well the treatment is working, so therapy can be adjusted faster and more precisely. Participants will use a special pace…