DYSTONIA

This study tested whether taking zinc by mouth every day is safe and doable for people with GNAO1-related disorders, a rare genetic condition causing movement problems, seizures, and developmental delays. Thirteen participants aged 6 months to 30 years took zinc for 6 months. Res…

This study tested a drug called dipraglurant in 15 people with blepharospasm, a condition causing uncontrollable eyelid spasms. Participants received either 50 mg, 100 mg, or a placebo to see if the drug is safe and can reduce symptoms like blinking and eye closure. The goal is t…

This study looked at how the cerebellum, a brain region key for movement, influences brain plasticity in people with dystonia (a movement disorder) and healthy volunteers. Researchers used mild brain stimulation to temporarily change cerebellar activity and measured effects on br…

This study looked at how a brain chemical called acetylcholine works in people with dystonia, a condition that causes muscles to contract on their own. Researchers used PET and MRI scans to compare brain activity in 31 adults with dystonia and healthy volunteers. The goal was to …

This study looked at how two brain regions—the cerebellum and striatum—communicate in people with dystonia caused by ADCY5 or PRRT2 gene mutations. Researchers used MRI scans and mild brain stimulation to compare patients with healthy volunteers. The goal was to better understand…

This study looked at how people with dystonia, essential tremor, or Parkinson's disease adapt their eye movements compared to healthy volunteers. Researchers used a special eye-tracking task to measure changes in saccade (quick eye movement) accuracy. The goal was to better under…

This study tested how accurately a robot system called Neurolocate can guide deep brain stimulation surgery. 18 patients with Parkinson's disease, dystonia, or tremor took part. The goal was to see if the robot hits its target as planned, which could make surgery faster and more …

This study aimed to learn more about why people have tremors by observing brain activity and movement in 85 adults with conditions like Parkinson's disease, essential tremor, or dystonia, as well as healthy volunteers. Participants completed tasks while researchers used tools lik…

This study looked at how the brain controls movement in adults with conditions like Parkinson's disease, Tourette's syndrome, and dystonia, compared to healthy volunteers. It used brain scans and other tests to gather information, but did not provide any treatment. The goal was t…

This study looked at how a specific brain chemical system (cholinergic) works in people with a genetic form of dystonia, a condition causing muscle spasms and abnormal postures. Researchers used PET scans to measure chemical activity in the brain. The goal was to better understan…

This study looked at how dystonia affects thinking, mood, and brain activity. Researchers tested memory, attention, and emotions in 102 adults with dystonia. They also used EEG to measure brain waves. The goal was to better understand non-motor symptoms, not to test a treatment.