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Breathing battle: biofeedback vs. retraining for vocal cord trouble

NCT ID NCT05770518

Symptom relief Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two non-drug treatments for paradoxical vocal fold motion (PVFM), a condition where vocal cords close when they should open, causing shortness of breath. Fifty-one adults were randomly assigned to either biofeedback (watching their breathing on a screen) or laryngeal control therapy (learning relaxation and breathing techniques). Researchers measured symptom changes using a breathing difficulty questionnaire to see which approach works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
biofeedback and laryngeal control therapy
What this could lead to
If this works, it could point toward a more effective, non-drug treatment for breathing difficulties caused by vocal cord dysfunction.
What could go wrong
This is a small pilot study with only 51 participants, so results may not apply to everyone. The treatments are behavioral and may not work for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

51 people

The number who actually took part.

Started

Mar 2023

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women aged 18 or older * Referral to the Washington University School of Medicine Voice and Airway Center for concerns for PVFM * Pre-treatment Dyspnea Index score of 11 or higher (representing the threshold for having an abnormal score) * Answer yes to the following questions: "Do you sometimes have difficulty breathing?" and "When you have difficulty breathing, is it worse when inhaling (breathing in)?" Exclusion Criteria: * Inability to speak or understand English * Previous treatment of PVFM * History of laryngeal surgery * Evidence of alternative laryngeal pathology (e.g. subglottic stenosis, benign or malignant obstructive mass) on flexible laryngoscopy as performed as part of routine clinical care

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Conditions

The condition(s) this trial relates to.

Cough Dyspnea laryngeal abductor paralysis laryngeal adductor paralysis Respiratory Sounds spasmodic dystonia Vocal Cord Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Paradoxical vocal fold motion Vocal cord dysfunction

Contacts and locations

Locations

  • Washington University

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.