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Hidden breathing blockage found in severe asthma patients

NCT ID NCT04593394

Knowledge-focused Sponsor: Haukeland University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how often people with severe asthma also have inducible laryngeal obstruction (ILO), a condition where the voice box closes during exercise, making breathing harder. Researchers tested 116 participants using a special scope while they walked on a treadmill and tracked their symptoms for a year. The goal was to understand how common ILO is and how it changes over time, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors better diagnose and manage breathing problems in people with severe asthma.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly improve health. Results may not apply to all asthma patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

116 people

The number who actually took part.

Started

Nov 2020

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The sample size of the cohort with severe asthma will be: All patients with severe asthma followed in our clinic for severe asthma estimated to be around 80 participants, of them, we hope to recruit at least 40 to perform the CLE-test, and we plan to recruit 40 participants with mild asthma and 40 age- and gender matched control subjects without asthma

Ages

18 to 70 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with severe asthma (GINA 5) * Patients with mild-moderate well-treated asthma (GINA step 1-4) * Agroup of age- and gender matched control subjects without asthma also aged 18- 70. * The patients must have had a stable disease the last one month before performing the CLE-test Exclusion Criteria: * No have underlying neurologic disease. * No known cancer in the lung-head-neck * No known vocal cord pathology. * No history of life-threatening asthma required hospitalization.

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Conditions

The condition(s) this trial relates to.

asthma chronic asthma laryngeal abductor paralysis laryngeal adductor paralysis Vocal Cord Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asthma chronic Vocal cord dysfunction

Contacts and locations

Locations

  • Haukeland University Hospital

    Bergen, 5021, Norway

More trials for these conditions

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