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Scientists scan brains to uncover hidden links between movement and mood in rare disorder

NCT ID NCT05671068

Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at how the cerebellum is involved in movement, thinking, and emotions in people with myoclonus dystonia, a rare movement disorder. Researchers used MRI scans to compare brain activity in 47 participants while they performed small tasks. The goal was to better understand why many patients also experience psychiatric symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help scientists understand why people with myoclonus dystonia often have psychiatric symptoms, possibly pointing toward better treatments in the future.
What could go wrong
This is a small, completed observational study with only 47 participants. It was not designed to test a treatment, so any insights are preliminary and may not lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

47 people

The number who actually took part.

Started

Jan 2023

Finished

Feb 2024

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study will enroll patients with DYT-SGCE and Healthy Volunteers (HVs).

Ages

15 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For all participants: * Age between 15-60 years * Able to give informed consent. For patients: * An established diagnostic of DYT-SGCE * No change in medication (related to DYT-SGCE) for a month For controls: * No neurological symptoms * No medication except oral contraception Exclusion Criteria: * No deprivation of liberty * Inability to give a consent * Established cognitive alteration * Contraindication to MRI (per MRI safety checklist) * Severe chronic psychiatric illness

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Conditions

The condition(s) this trial relates to.

myoclonus-dystonia syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DYT11 Myoclonus-dystonia

Contacts and locations

Locations

  • Brain Institute

    Paris, Paris, 75013, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.