Commensal bacterial infectious disease

This study looks at two methods of giving beta-lactam antibiotics to patients with sepsis or septic shock in the ICU: a slow 4-hour infusion versus a quick 30-minute infusion. Researchers will track survival at 90 days and whether the infection clears within 14 days. The goal is …

This trial is testing whether adding an immune-stimulating drug called nogapendekin alfa inbakicept (NAI) to standard intensive care can help adults with sepsis or septic shock. Participants receive NAI as an injection under the skin on the first day, with possible additional dos…

This study tests whether sivelestat, a drug used in Japan for lung injury, can help restore the body's ability to break down harmful blood clots in people with septic shock. About 120 adults with septic shock and early blood clotting problems will receive either sivelestat or a p…

This trial tests whether a 7-day course of doxycycline can effectively cure asymptomatic anal lymphogranuloma venereum (LGV), a sexually transmitted infection caused by Chlamydia trachomatis. Currently, treatment lasts 21 days, but recent studies suggest a shorter course may work…

This study tests whether a drug called Angiotensin II works better than the usual treatment (norepinephrine) for people with septic shock, a life-threatening condition where blood pressure drops dangerously. About 78 adults with septic shock will receive either Angiotensin II or …

This trial investigates whether keeping magnesium levels in the upper normal range can lower the amount and duration of norepinephrine, a drug that raises blood pressure, in adults with septic shock. Participants are randomly assigned to receive individualized magnesium infusions…

This pilot trial tests whether a special cartridge placed in a blood-filtering machine can improve outcomes for people with septic shock, a severe and often deadly infection response. The cartridge is designed to remove inflammatory molecules from the blood, which may reduce orga…

This trial investigates whether a blood-filtering device called CytoSorb can reduce damage to blood vessels in people with septic shock, a life-threatening condition. The device removes inflammatory molecules from the blood. Researchers will measure changes in a marker of vessel …

This trial tests a device called Nucleocore that removes cell-free DNA (cfDNA) from the blood of people with septic shock. High cfDNA levels are linked to severe inflammation and worse outcomes. The study enrolls adults aged 18-65 with septic shock and elevated cfDNA, and measure…

This study tests whether special blood purification devices can help people with septic shock, a life-threatening condition where infection causes organ failure. The trial includes adults aged 18 to 80 with severe septic shock. Depending on their level of endotoxins, patients rec…

This Phase 2 trial tests whether adding the drug nogapendekin alfa inbakicept (NAI) to standard sepsis care can improve survival in critically ill adults with sepsis and persistently low lymphocyte counts (a sign of immune suppression). About 50 participants will be randomly assi…

This study tests whether a sedative called dexmedetomidine can improve survival in people with refractory septic shock, a life-threatening condition where blood pressure stays dangerously low despite standard treatments. The drug aims to calm an overactive stress response that ma…

This study tests a new care model for veterans with opioid use disorder that combines infectious disease screening and treatment with their usual medication-assisted therapy in a single appointment. The goal is to make it easier for veterans to get tested and treated for infectio…

This study tests whether dapagliflozin, a drug used for diabetes, can help people with septic shock—a severe infection that causes organ failure. The drug aims to protect blood vessels and reduce inflammation. About 568 ICU patients will receive either dapagliflozin or a placebo,…

This study looks at whether giving vitamin C through a vein can help very sick patients with liver failure and severe infections recover from kidney injury. About 110 patients will get either standard care alone or standard care plus vitamin C. The goal is to see if vitamin C hel…

This study tests whether giving the sedative dexmedetomidine early to adults with septic shock can calm their overactive nervous system and improve survival. 168 participants will receive either the drug or a placebo for 48 hours, with close monitoring of heart function, inflamma…

This study will test whether a standardized set of emergency steps—including early screening, blood tests, fluids, and antibiotics—can improve survival for sepsis patients. Researchers will compare outcomes for 120 adults treated before and after the new protocol is introduced. T…

This study tests whether giving intravenous fluids and a blood-pressure-raising drug (norepinephrine) together early can prevent acute kidney injury in adults with septic shock. Researchers will treat 100 patients in the ICU or emergency department and monitor kidney function and…

This study tests whether a non-invasive arm cuff procedure, called remote ischemic postconditioning, can reduce deaths in adults with septic shock. The cuff is inflated and deflated in cycles to briefly restrict blood flow, which may trigger protective effects. 720 ICU patients w…

This study tests a blood purification filter called Oxiris in adults with septic shock and organ failure. Researchers want to see if it lowers the risk of death or worsening organ function within 7 days. Participants will receive the filter treatment for up to 3 days in the ICU a…

This pilot study tests whether using ultrasound to guide treatment with the beta-blocker esmolol is feasible in patients with septic shock. Septic shock is a life-threatening condition where infection causes very low blood pressure and a dangerously fast heart rate. The trial wil…

This study tests whether giving extra human albumin—a natural blood protein—along with standard care can help people survive septic shock after surgery. Septic shock is a life-threatening condition where infection causes dangerously low blood pressure. The trial will enroll 304 a…

Researchers are testing whether sex work managers, called queen mothers, can hand out and collect HIV self-tests and self-collected STI test kits at places where female sex workers meet and work in Lusaka. The study compares this peer-supported approach with the current standard …

Sepsis is hard to spot early because its first symptoms look like many other conditions. Researchers at emergency departments in Taiwan are studying whether two blood markers, presepsin and immature granulocytes, can help doctors tell sepsis apart from other causes of inflammatio…

Researchers are building a web-based simulation platform to model how long blood cultures take from collection to result reporting in sepsis cases. The study involves microbiological laboratories that perform blood culture analysis. The goal is to understand how lab infrastructur…

This trial tests two ultrasound techniques to see which one detects fluid overload earlier in adults with septic shock who need fluid resuscitation. One method uses lung ultrasound, the other measures blood flow velocity in the heart's main outflow tract. Researchers will compare…

This study looks at whether measuring oxygen levels in a central vein can help doctors decide if a patient with septic shock needs more fluids. About 115 adults with septic shock will have their oxygen levels checked before and after a fluid challenge. The results will be compare…

This trial is testing whether the GeneXpert system, a portable device that can run multiple tests, can accurately detect HIV, chlamydia, gonorrhea, hepatitis C, and HPV in community health centers and clinics. Researchers will compare its results to standard lab tests and track w…

This study tests whether an automated algorithm called SmartWedge can accurately measure pulmonary artery occlusion pressure (PAOP) in intensive care patients with septic shock. PAOP is a key measurement for guiding treatment, but manual readings can vary. The trial compares the …

This study aims to validate a new blood test that uses artificial intelligence to detect disseminated intravascular coagulation (DIC) early in patients with septic shock. DIC is a severe clotting disorder that often leads to death, but current diagnostic methods are complex and r…

This study will test whether a new, continuous method of measuring heart function (using pressure waves) matches the current standard method (thermodilution) in 43 ICU patients with septic shock. Both methods use the same catheter already placed for treatment. The goal is to see …

This study looks at whether a blood gas measurement (the difference in carbon dioxide between central venous and arterial blood) can accurately diagnose low cardiac output in patients with septic shock from severe skin infections. About 74 adults will be monitored during hyperbar…

This study will test whether a fast, point-of-care test for chlamydia and gonorrhea can reduce the time it takes for people to start antibiotics. Four hundred asymptomatic adults visiting a sexual health clinic will be randomly assigned to receive either the rapid test or a stand…

This trial tests whether teaching families to wash children's hands and faces with soap can lower the rate of active trachoma, a bacterial eye infection that can lead to blindness. About 990 children aged 1-9 in central Ethiopia will take part, with some households receiving a st…

This trial tests whether taking a single dose of the antibiotic doxycycline within 24 hours of condomless sex can prevent bacterial sexually transmitted infections (STIs) like chlamydia, gonorrhea, and syphilis in women aged 18–35 at increased risk. Participants are randomly assi…

This study tests a program called ICU-SUCCEED, designed to help survivors of acute respiratory failure and their family caregivers cope and manage recovery together. The program includes one in-person session and four follow-up sessions by phone or video, focusing on communicatio…

This study aims to find the best way to dose the antibiotic ceftazidime for patients in intensive care with serious infections. Many ICU patients don't get enough of the drug because their bodies process it differently. The researchers will test a personalized dosing plan to keep…

Researchers are studying whether repeated bedside ultrasound scans of the diaphragm can predict breathing failure in adults with septic shock. The study follows 120 patients in intensive care for up to 72 hours, measuring how far the diaphragm moves and how thick it is. The team …

Researchers at Assiut University are studying whether ionized calcium levels, measured from a routine blood sample when a patient enters the ICU, can signal how severe sepsis or septic shock is. The study follows 160 adults admitted to intensive care within 24 hours of presentati…

Researchers at Vanderbilt University Medical Center want to understand how immune cells use glucose, the body's main sugar, during critical illness. They give 25 adult ICU patients an intravenous infusion of a non-radioactive carbon-13 glucose tracer over a few hours. Then they c…

This study looks at whether brain activity patterns, measured by EEG, can help predict long-term thinking problems in people with sepsis. Researchers will monitor brain waves for 72 hours in 78 ICU patients with different types of inflammation. They will then track cognitive func…

This study looks at whether certain proteins in the blood, which signal brain injury, can predict memory and thinking problems in people who survive sepsis or septic shock. Researchers will measure these biomarkers in 210 adults admitted to intensive care and check their cognitiv…

Sepsis happens when the body's immune response spirals out of control, damaging organs and causing about 1 in 5 deaths worldwide. This study follows 500 adults hospitalized with sepsis to track how their immune systems change over time. Researchers will collect blood samples and …

This pilot study tests whether a new index, based on changes in hemoglobin levels after a standard fluid infusion, can measure capillary leak in people with septic shock. Researchers will compare this index to known markers of blood vessel damage in 100 ICU patients. If it works,…

Septic shock is a life-threatening condition with high mortality. This study investigates whether patients with septic shock have a deficiency of angiotensin II, a hormone that helps regulate blood pressure. Researchers will measure hormone levels in blood and urine samples from …

This study looks at how the drug vasopressin affects the heart and blood flow in people with septic shock, a life-threatening condition from severe infection. Researchers want to see if different patients respond differently based on their specific heart and blood vessel status. …

This study investigates whether Doppler ultrasound, a non-invasive imaging technique, can measure blood flow to the gut in patients with septic shock. The goal is to see if these measurements correlate with how well the body clears lactate (a marker of tissue oxygen debt), the se…

This study observes how the bodies of people with septic shock respond to fluid loading, a common treatment. Researchers track markers of blood flow and fluid buildup to see which patients improve and which get worse. The goal is to find better ways to give fluids without causing…

This study looks at 200 people with pneumonia to find out how many actually have an infection caused by Chlamydia pneumoniae, a type of bacteria. Researchers will use PCR tests to check for the germ and compare results with standard care. The goal is to see if this infection is o…

This study looks at how sepsis affects the bone marrow, where immune cells are made. Researchers will compare bone marrow samples from 45 people: those with sepsis, other critically ill patients, and healthy volunteers. The goal is to understand why sepsis can weaken the immune s…

This study looks at how esmolol, a drug that slows the heart rate, affects the smallest blood vessels in people with septic shock—a severe infection that can lead to organ failure. Researchers will measure changes in blood flow under the tongue and other key pressures in the circ…

This study looks at how the sedative dexmedetomidine affects the smallest blood vessels in people with septic shock, a life-threatening condition caused by severe infection. Researchers will measure blood flow in the tongue's tiny vessels and other key blood pressure indicators b…

This study tests whether the drug papaverine can improve blood flow in the smallest blood vessels of people with septic shock. Septic shock causes widespread inflammation and poor circulation, which can damage organs. The trial will give papaverine intravenously to 20 adults in t…

This pilot study will test a drug called anisodamine in 20 adults with septic shock who are on a ventilator. The goal is to see if the drug can improve blood flow in small blood vessels and help with a phenomenon called 'vascular waterfall.' This is a very early study to gather i…

This study tests whether a safe dose of ivermectin, a common deworming drug, can make human feces deadly to flies that spread trachoma. Trachoma is a leading cause of blindness, and these flies carry the bacteria from person to person. Twelve healthy adults will take ivermectin, …

This study tests whether training healthcare providers to reduce stigma can increase the use of HIV and STI prevention services, like testing and preventive medications. It will involve 8 clinics in the Mississippi Delta and track changes in how often patients receive these servi…

This small pilot study tests whether a Chinese herbal medicine called Shenfu Injection can improve blood flow in people with septic shock, a life-threatening condition. Twenty adults in the ICU will receive the injection, and doctors will measure changes in circulation and oxygen…

This study looks at whether measuring the fluorescence of certain white blood cells (neutrophils) can help doctors quickly identify sepsis patients at risk of severe complications like organ failure or septic shock. Researchers will analyze blood samples from 492 adults in the em…

This study looks at how satisfied young people and those with low incomes are with free HIV and STI testing and counselling in Lucerne and Zurich. Around 1,800 participants will fill out a questionnaire after their visit. The goal is to see if these free services meet people's ne…

This study will observe the real-world treatment of 5,000 adults with septic shock in intensive care units across many countries. Researchers want to see how closely doctors follow official guidelines and what factors influence their choices. The goal is to identify gaps in care …

This pilot study tests whether giving sepsis survivors a simple educational brochure when they leave the intensive care unit (ICU) is feasible. Researchers will enroll 30 adults with sepsis and randomly assign them to receive either usual care or the brochure plus a chance to ask…

This observational study will look at 400 adults with sepsis and unstable blood pressure to understand how their heart and blood vessels are affected. Researchers will use ultrasound and blood tests to classify patients into different groups based on their heart and blood vessel …

This study will use echocardiograms (heart ultrasounds) to see how the heart responds to two common treatments for septic shock: intravenous fluids and vasopressors (medicines that raise blood pressure). Researchers will measure changes in heart function before and 15 minutes aft…

This study looks at whether intensive care nurses can learn to use a special ultrasound method called VExUS to find early signs of blood buildup in the veins of sepsis patients. Sepsis can cause organ damage, and this buildup may make it worse. The study will train nurses, check …

This study looks at whether the urea-to-creatinine ratio in blood can track metabolic changes in patients with septic shock. Currently, doctors use a special machine (indirect calorimetry) to measure energy needs, but it's not always available. Researchers will compare the simple…

This study will enroll 100 adults with septic shock to compare two non-invasive methods for measuring how well the heart is pumping blood: standard ultrasound (echocardiogram) and a newer device called electrical cardiometry, which uses sensors on the chest. The goal is to see if…

This study will measure thyroid and adrenal hormone levels in 200 ICU patients with septic shock. The goal is to understand how these glands are affected during severe infection. No treatment is given; the study only observes and records hormone changes.

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…

Sepsis is a life-threatening reaction to infection, and choosing the right antibiotic quickly is critical. This study will analyze data from 10,000 adults treated for sepsis in an emergency department to build a predictive model that estimates the likelihood of multidrug-resistan…