Commensal bacterial infectious disease

This study looks at whether giving steroids very early to patients with severe infections and low blood pressure works better than waiting until standard treatments fail. About 230 adults will be randomly assigned to get either early steroids or a placebo, and neither they nor th…

This study tested whether using a urine biomarker test (NephroCheck) to guide treatment could reduce kidney injury, dialysis, or death in sepsis patients. The trial planned to enroll many participants but was stopped early after only 19 people joined. The idea was to catch kidney…

This study looked at 500 adults with septic shock and severe acute kidney injury to see if starting dialysis early (within 12 hours) or waiting (48-60 hours) affected survival at 90 days. The trial was terminated early, so the results are not conclusive. The goal was to find the …

This study tested whether a sedative drug called dexmedetomidine could help restore blood pressure control in patients with severe septic shock that does not respond to standard treatments. The trial involved 32 adults in intensive care. The goal was to see if the drug could impr…

This study tested whether the oral drug midodrine could help people with septic shock stop needing IV blood pressure support sooner. The trial planned to enroll many patients but was stopped early with only 10 participants. Because it was so small, we cannot draw firm conclusions…

Sepsis and septic shock cause widespread inflammation and organ failure, and problems with the smallest blood vessels may drive worse outcomes. Researchers are testing whether a non-invasive eye imaging technique called optical coherence tomography angiography (OCTA) can detect t…

This study tested whether a gas sedative (isoflurane) could help patients with septic shock wake up and get off a breathing machine faster than standard IV sedation (midazolam). The goal was to reduce complications from long-term sedation and ventilation. Only one patient was enr…

This study tested whether raising the blood pressure target from 65 mmHg to 85 mmHg in patients with septic shock could help prevent kidney injury. Researchers used a drug called norepinephrine to adjust blood pressure and monitored kidney function. The trial was stopped early an…

This observational study aimed to understand why some septic shock patients respond better to the drug vasopressin. Researchers planned to compare blood markers, heart ultrasound images, and tissue oxygen levels between responders and non-responders. However, the study was termin…