Heart ultrasound may guide better septic shock treatment
NCT ID NCT07438301
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will use echocardiograms (heart ultrasounds) to see how the heart responds to two common treatments for septic shock: intravenous fluids and vasopressors (medicines that raise blood pressure). Researchers will measure changes in heart function before and 15 minutes after treatment in 180 adults with septic shock. The goal is to understand which approach improves blood flow better, which could help doctors make more informed resuscitation decisions.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors choose the best resuscitation method for septic shock patients based on heart function changes.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly test a new therapy. Results may not apply to all patients, and the small size (180 participants) limits generalizability.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 180 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult critically ill patients whom admitted to either medical or surgical intensive care units (MICU, SICU) at Siriraj Hospital
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients aged ≥18 years * Diagnosis with Septic Shock (Sepsis-3 Definition of Septic Shock) * Hypotension, SBP \< 90 mmHg, or mean arterial BP \< 65 mmHg Exclusion Criteria: * Patients who receive two or more vasopressors * Patients who receive inotropic medications * Patients who receive simultaneously fluid with vasopressor resuscitation * Patients with insufficiently quality ultrasound images for determining echocardiography * Patients or their legally authorized representatives (LAR), who decline participation in the study or are unable to provide informed consent before enrollment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Siriraj Hospital
Bangkok, 10700, Thailand
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Chilling fever: can cooling septic shock patients save lives?
- Bedside eye scans may reveal hidden blood flow problems in septic shock
- Can two blood markers catch sepsis before it turns deadly?
- Two cheap blood ratios put to the test as sepsis death predictors
- Can a bedside ultrasound predict which septic shock patients will stop breathing on their own?
- Can a computer model speed up sepsis blood tests?