Bone fracture

This study compares getting flap surgery within 72 hours of a severe leg injury versus waiting longer. The goal is to see if faster surgery reduces death, amputation, infections, and hospital stays. About 356 adults with open fractures or dislocations below the knee will take par…

Researchers are collecting data on ViviGen, a donated cellular bone matrix used as a graft during orthopaedic surgery. The study follows patients with acute fractures, delayed healing, non-union fractures, or spinal fusion to see how often they need a second operation within a ye…

This study compares oral (pill) antibiotics to intravenous (IV) antibiotics for treating infected broken bones that haven't healed properly. About 250 adults with this condition will be randomly assigned to receive either oral or IV antibiotics for up to 6 weeks after surgery. Th…

This study will follow 120 adults aged 60 and older who have a pelvic fracture and are scheduled to receive the iFuse TORQ TNT implant, a screw-like device that stabilizes the pelvis. Researchers will check if the device stays in place, doesn't break, and doesn't require addition…

This trial compares two ways of treating a common ankle fracture in children: wearing a cast for six weeks versus using a boot and starting movement early. The goal is to see if the longer cast time helps the broken bone piece heal back together, preventing a small extra bone fro…

This study is following 35 adults who have received a Tipmed revision hip prosthesis during routine care. Researchers will track how well the hip works and any complications over 24 months. The goal is to see if the device performs safely and effectively in real-world use.

This study is testing a material called Neocement Inject P, used to rebuild bone in the jaw for dental implants. Researchers will follow 66 adults to see if the material is safe and helps grow enough bone for implant placement. The goal is to gather real-world evidence on how wel…

This study compares two common surgeries for wrist fractures that involve the joint surface: a volar locking plate (a metal plate placed inside the wrist) and an external fixator (a frame outside the arm with pins into the bone). Researchers will measure how long the surgery take…

This study is testing whether taking an antibiotic pill for 7 days after surgery to fix a broken leg, ankle, or foot can lower the chance of wound infection in adults with poorly controlled diabetes. About 40 participants will either receive the antibiotic or standard care (no ex…

This study compares two types of zirconia materials used in full-mouth dental implants: monolithic zirconia (a single, solid ceramic) and zirconia-feldspathic (a ceramic with a porcelain veneer). Researchers will track complications like chipping, cracking, or other issues over a…

This study is testing the safety and performance of the RibFix Titan™ device, used to fix broken ribs or during chest wall surgery. Researchers will follow 54 adults for 90 days after surgery to see how well the device works and if any additional procedures are needed. Participan…

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This study follows 300 people who receive the IlluminOss device to treat broken bones from injury or disease. Researchers will track how well the device works, how safely it performs, and how patients recover over time. The goal is to gather real-world data on bone healing and re…

This study compares two surgical approaches for fixing certain types of fractures at the bottom of the thighbone (distal femur). One group gets a single implant (a plate or a rod), while the other gets two implants (a plate plus a rod or an extra plate). The goal is to see which …

This study is testing special screws that dissolve over time, used in foot and ankle surgeries for fractures, realignments, or joint fusions. The screws are meant to hold bones together while they heal, then safely absorb into the body. Researchers will follow 125 adults for 4 ye…

This study tests whether applying Prontosan antimicrobial gel to the skin during shoulder replacement surgery can reduce bacteria that might cause infections. It involves 60 adult men having their first shoulder replacement. Researchers will compare infection-related bacteria lev…

This study will follow 600 people who receive an FX artificial shoulder implant for conditions like arthritis, rotator cuff problems, or shoulder fractures. Researchers will measure pain, shoulder function, implant survival, and any complications over time. The goal is to see how…

This study is testing a fracture liaison service (FLS) combined with medication management for people with osteoporosis in a rural area. The program provides education, monitoring, and follow-up to help patients take their medications as prescribed. Researchers will enroll 200 ad…

This study tests a treatment called BonoFill-II for people with severe bone fractures that won't heal on their own. The treatment uses a patient's own cells to help grow new bone. The goal is to see if it is safe and can restore the bone and the ability to use the limb. About 40 …

This study tests whether a supplement called ossein-hydroxyapatite complex (Osteogenon) can help broken bones heal better and faster. Researchers will track 150 adults with fractures to see if the supplement improves bone union, reduces pain, and supports recovery. The goal is to…

This study is checking how long the Medacta Shoulder System lasts and how well it works in 200 people with shoulder issues like arthritis, fractures, or failed previous shoulder replacements. Participants will be followed over time to measure shoulder function, pain, and movement…

This study is testing whether a bedside ultrasound can accurately detect skull fractures in children aged 6 and under who have minor head injuries with a scalp bruise. Researchers will compare ultrasound results to a standard CT scan in 150 children. If ultrasound proves reliable…

This study tests whether a special dye called ICG, used with a new imaging device, can help surgeons see how healthy a patient's bone is during surgery. Ten adults with open fractures or bone infections will receive the dye and be imaged. The goal is to see if this technique can …

This study is testing a new portable X-ray machine called Dynamic Digital Radiography (DDR) that takes 15 images per second to show how the lungs move and blood flows. Researchers at Brigham and Women's Hospital will use it on 230 ICU patients with various lung conditions to see …

This study is testing whether taking high-dose fish oil supplements during pregnancy can prevent asthma and persistent wheezing in early childhood. The trial will enroll 2000 pregnant Danish women with low blood levels of omega-3s. Participants take fish oil or placebo capsules d…

This study is testing whether taking a higher dose of vitamin D during pregnancy can prevent asthma and persistent wheezing in children up to age 3. Researchers will give 2000 pregnant women either vitamin D or a placebo daily from week 22-26 of pregnancy until one week after del…

This study tests whether naringenin, a natural compound found in grapefruit and citrus fruits, can speed up bone fusion and reduce inflammation in people with leg fractures. Researchers will give 70 adults either naringenin or a placebo after surgery and measure bone healing rate…

This study tests whether giving lidocaine through an IV during surgery can lower the amount of opioids needed for pain in children aged 3-18 having arm fracture repair. Half the children will get lidocaine, half a placebo, and researchers will compare opioid use and pain scores. …

This study tests whether a therapist-guided exercise program helps people aged 50 and older recover better from a wrist fracture compared to usual care advice. Participants will either receive supervised exercises or standard self-management advice. The main goal is to see if the…

This study compares buprenorphine to a standard opioid (hydromorphone) for pain relief in adults aged 65 and older who come to the emergency department with a broken bone. Researchers want to see if buprenorphine works just as well but causes fewer side effects like nausea, confu…

This study tests a medical device called VCFix to treat broken vertebrae (spinal bones) from compression fractures. The goal is to reduce pain and improve movement in 103 adults aged 21-85 with a single recent fracture. The device is placed into the bone to restore height and sta…

This study looks at whether using a continuous passive motion (CPM) machine—a device that gently moves the leg—can help control pain and reduce the need for strong painkillers after surgery for certain leg fractures. About 100 adults who have had surgery for a broken hip socket, …

This study looks at whether giving children a nerve block before elbow fracture surgery can help control pain afterward and reduce the need for strong painkillers like oxycodone. About 90 children with a specific type of elbow fracture will be randomly assigned to receive either …

This Mayo Clinic study tests whether using a virtual reality (VR) headset can reduce pain and the need for opioid painkillers in 100 adults hospitalized with a broken bone. Participants will use a VR program while in the hospital, and researchers will track their pain medication …

This study tests whether socks made with semiconductor fabric can improve healing and reduce symptoms after an ankle sprain. About 100 adults with ankle injuries will wear either the special socks or regular compression socks and report their pain and function over time. The goal…

This study compares a nonopioid pain control plan to standard opioid pain medicine in 75 adults after surgery for a broken collarbone. The goal is to see if the nonopioid plan can control pain just as well while reducing opioid side effects and addiction risk. Participants are ra…

This study compares two simple breathing exercises—deep breathing and using a spirometer (a device that measures how much air you breathe in)—to see which one helps people with broken ribs breathe better. The trial will enroll 104 patients with rib fractures from chest trauma. Th…

This study is testing whether adding a sensor-based device to standard physical therapy can improve both thinking and movement in frail older adults recovering from hip fracture surgery. Thirty participants aged 65-89 will use the device for part of their rehab. The goal is to se…

This study looks at whether starting physical therapy soon after surgery for a specific knee fracture (tibial spine avulsion) helps people recover better than waiting longer. It includes 56 people aged 15-25 who had the surgery. Researchers will measure knee movement, muscle stre…

This study tests if freezing the nerves between the ribs (cryoablation) provides better pain relief than a numbing catheter placed near the spine for people with multiple broken ribs. About 48 adults with more than one rib fracture will be randomly assigned to one of the two trea…

This study looks at whether adding local muscle vibration to standard rehabilitation can help elderly patients (75+) recover strength and mobility after a hip fracture. The vibration is applied to the leg muscles for 30 minutes, five times a week, for four weeks. The main goal is…

This study compares two drugs, dexmedetomidine and ketamine, to see which one better helps diaphragm function and pain in people with three or more broken ribs who are not having surgery. Sixty adults will receive a low-dose infusion of one drug or a placebo for five days. The go…

This study tests a device called Addinex that controls and monitors opioid use after a bone fracture. About 100 people will either use the device or a standard pill bottle. The goal is to see if the device helps people take fewer opioids and dispose of leftover pills more often.

This study tests whether a 12-week course of a cetylated fatty acid supplement can improve bone healing after surgery for a broken femur or tibia. One hundred adults will receive either the supplement or a placebo, and healing will be tracked with X-rays and pain scores. The goal…

This study tests whether having a social worker in the fracture clinic helps people recover after a serious broken bone. 2,000 adults who had surgery for a fracture will either get social work support or usual care. The social worker helps with mental health, financial problems, …

This study tests whether a single injection of a long-acting anesthetic (Exparel) can control pain as well as a catheter that delivers continuous anesthetic after leg fracture surgery. Ninety adults with closed leg fractures will receive either the single shot or the catheter bef…

This study tests two lighter pain control methods for children aged 3 to 17 who need a wrist fracture reduction. One method uses a numbing injection (hematoma block) with a low dose of ketamine, and the other uses the same block with fentanyl nasal spray. These are compared to th…

This study looks at whether adding art or color to a child's cast can improve their satisfaction and reduce how much pain they feel after breaking an arm or leg bone. About 96 children aged 5 to 17 will be randomly assigned to get a plain white cast, a colored cast, or a custom-d…

This study tests whether a continuous nerve block (CINB) plus standard pain medication works better than pain medication alone for people with multiple broken ribs. 180 adults with at least two rib fractures will be randomly assigned to one of two groups. The main goal is to see …

This pilot study tests a procedure called cryoneurolysis, which uses a tiny freezing tool to temporarily numb the nerves around broken ribs. The goal is to see if it's practical to run a larger study comparing this technique plus standard pain care to standard care alone. Twenty-…

This study is tracking 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will measure pain, daily function, and strength using standard shoulder scores. The goal is to better understand the l…

This trial is testing a device that has not been approved by the U.S. FDA. The purpose is to learn about its safety and how it works in the body. Participants will help researchers understand if the device is promising for future use.

This study will compare two surgical methods for fixing a specific type of broken thigh bone near the knee in people aged 55 and older. Half the participants will get a single implant (a plate or a rod), while the other half will get two implants (a plate plus either a rod or a s…

This study aims to understand why bones weaken with age, leading to conditions like osteoporosis and osteoarthritis. Researchers will collect bone waste and blood samples from 2,000 people undergoing orthopedic surgery, including those with and without bone disease. By analyzing …

This pilot study explores whether an electrical impedance tomography (EIT) device can detect soft tissue injury in adults who have suffered high-energy fractures of the arms or legs. Participants will undergo EIT imaging in the emergency department, operating room, clinic, and ho…

This study tests whether a light-based imaging tool called optical coherence tomography (OCT) can spot bacteria or biofilm on bone, tissue, and surgical hardware during open fracture or infected fracture surgery. Researchers will enroll 40 adults to see if the technique is practi…

This study is testing a robotic system called Epione to help doctors place needles or instruments into the bones of the pelvis and spine. The goal is to see if the robot makes these procedures more feasible, safe, and accurate compared to doing them by hand. Sixty adults who are …

This study looks at how much fluid doctors should use when cleaning open fractures (broken bones that poke through the skin). About 200 adults will join for 12 months. Researchers will compare two different fluid amounts to see if one helps bones and wounds heal better with fewer…

This study looks at whether it's safe and satisfying to shower early after orthopedic fracture surgery, compared to waiting longer. About 56 adults with arm or leg fractures will be randomly assigned to bathe early or follow the traditional delayed approach. The goal is to see wh…

This study is looking at whether the way people with spinal muscular atrophy (SMA) walk can tell us about their bone health. Researchers will use special insoles to measure walking patterns and compare them with bone density scans and blood tests. The goal is to find simple, non-…

This study tests a simple conversation aid and brief training for doctors to improve discussions about anesthesia options with patients who need hip fracture surgery. About 1,881 adults aged 50 and older at six U.S. hospitals will take part. The goal is to see if this approach in…

This study aims to see if a new 3D classification system for shoulder fractures is reliable and reproducible. Researchers will review CT scans from 800 patients with proximal humeral fractures. The goal is to help doctors better diagnose and treat these injuries.

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study looks at whether drugs with anticholinergic effects increase the risk of bone fractures in people with rheumatoid arthritis. Researchers will track 100 patients, measuring their medication burden and bone density. The goal is to better understand how these commonly use…

This registry collects information from 600 adults who have a fracture near a hip or knee replacement. Doctors will record fracture type, treatment, and recovery to learn what works best. The goal is to improve patient safety and quality of care for these injuries.

This study is looking at 100 children aged 3 to 15 who have had a low-energy fracture (like a fall from standing height). Researchers want to see if vitamin D levels, bone markers, and weight are linked to fracture risk. They will compare children with fractures to those without.…