Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a sedative help heal broken ribs? new trial aims to find out

NCT ID NCT04928300

Symptom relief Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two drugs, dexmedetomidine and ketamine, to see which one better helps diaphragm function and pain in people with three or more broken ribs who are not having surgery. Sixty adults will receive a low-dose infusion of one drug or a placebo for five days. The goal is to improve breathing and reduce pain, which could speed recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexmedetomidine (a sedative) and ketamine (an anesthetic)
What this could lead to
If it works, this could point toward a better way to manage pain and improve breathing in people with multiple broken ribs, reducing complications.
What could go wrong
This is a small, early-stage trial with only 60 participants, so results may not apply to everyone. Both drugs have side effects like sedation or confusion.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2021

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (age 18-65 years) of American Society of Anaesthesiologists (ASA) physical status I-II * Traumatic multiple fracture ribs 3 ribs or more, who will be subjected to thorough assessments including chest 3D-CT * Undergoing conservative treatment (chest strappings) * Intractable pain with visual analogue scale (VAS) over 6 after traditional therapies * Glasgow Coma Scale (GCS) ≥ 13. Exclusion Criteria: * Multiple traumas to body parts other than chest with an abbreviated injury scale over 3 * Serious head trauma with a Glasgow coma scale lower than 13 * Mechanically ventilated patients * Massive hemothorax * Injury to the trachea or bronchus with requirement for immediate surgery * Dementia * Use of corticosteroids during ICU stay * Sepsis * Continued use of neuromuscular blocking agents and aminoglycosides antibiotic use as they are known risk factors for ICU-acquired weakness and any known hypersensitivity * Contraindication to the study drugs.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Rib fractures are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

bone fracture Rib Fractures

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rib fractures

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Assiut university hospital

    RECRUITING

    Asyut, Assuit, Assuit universi, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.