University Hospital Tuebingen

This study is testing a personalized peptide vaccine for children and young adults (up to age 30) with metastatic fusion-driven sarcomas (Ewing sarcoma, rhabdomyosarcoma, synovial sarcoma) who have completed standard treatment. The vaccine is custom-made for each patient based on…

This early-stage trial tests a personalized peptide vaccine for people with a rare liver cancer called fibrolamellar hepatocellular carcinoma (FLC) or other tumors that share a specific genetic change (DNAJB1-PRKACA fusion). The vaccine is designed to train the body's immune cell…

This study tests a treatment called Lecigon® for people with Parkinson's disease. It is a gel given through a tube into the intestine that delivers a steady dose of medication. The goal is to see if this method reduces certain behavioral and emotional side effects better than sta…

This study tests whether a non-invasive physical plasma treatment can clear HPV infections from the cervix. About 50 adults with HPV will receive the treatment, and researchers will check if the virus is gone afterward. The goal is to find a new way to prevent cervical cancer cau…

This study tests whether giving a higher dose of radiation along with a drug called bevacizumab can help people with a fast-growing brain tumor (glioblastoma) live longer. About 146 adults aged 18 to 70 with a specific type of glioblastoma will receive the treatment. The goal is …

This study tests whether intermittent fasting can improve how the body releases insulin in people with prediabetes or early type 2 diabetes. About 200 adults with a BMI between 25 and 40 will follow a 4-week fasting plan or a control diet. The goal is to see if fasting can boost …

This study tests whether robot-assisted groin lymph node removal causes fewer serious side effects than standard open surgery in 80 men with penile cancer. The goal is to reduce wound healing problems and other complications while still effectively controlling the cancer. Partici…

This study tests whether a special MRI-guided radiation machine (MR-linac) can deliver high-dose radiation precisely to rectal tumors, allowing patients to avoid surgical removal of the rectum. About 100 people with early-stage rectal cancer will receive this radiation along with…

This study tests a drug called tafasitamab in children aged 3 to 17 with B-cell leukemia that has come back or not responded to treatment. The drug is an antibody that helps the immune system find and kill leukemia cells. The trial has two parts: first, finding the best dose, and…

This study compares quality of life in adults with Crohn's disease during a flare when treated either with standard care or an adapted Crohn's disease exclusion diet plus partial enteral nutrition. The diet limits certain foods and uses a nutritional drink (Modulen) to help contr…

This study is testing an artificial intelligence system that can automatically detect smoke gas produced during laparoscopic surgery. Researchers will collect video data from 30 women undergoing procedures that use high-frequency surgery, which creates smoke. The goal is to train…

This study tests an app that provides information and mental health screening for parents of premature babies born between 28 and 34 weeks. The goal is to help families cope with stress and identify problems early. About 120 families will use the app or receive standard care, and…

This study tests whether a noninvasive brain stimulation technique, timed to the patient's own brain waves, can improve arm and hand movement after an ischemic stroke. Researchers will enroll 144 adults who had a stroke 1-14 days ago and have significant arm weakness. Participant…

This study tests a mindfulness program called 'Healthy Under Stress' to see if it can lower stress levels in employees, patients, and their families. Researchers will measure stress using a standard questionnaire before and after the program. The goal is to find a practical, non-…

This study looks at whether advanced imaging can detect a hidden heart condition called cardiac amyloidosis in people with severe aortic valve stenosis. The condition can complicate treatment and recovery. Researchers will use echocardiography, CT, and SPECT/CT scans to check for…

This study follows 1,000 adults with diabetes to find early signs that predict serious complications like nerve damage, eye disease, kidney problems, and heart issues. Researchers measure blood sugar control and other health markers over time. The goal is to develop better risk a…

This study follows 845 people who previously received a Melody valve implant to treat congenital heart disease. Researchers will track serious events like death, repeat surgery, or infection over many years. The goal is to understand how well the valve performs long-term after it…

This study looks back at genetic test results from about 12,000 people with rare diseases or family cancer syndromes. Researchers want to see how often exome or genome sequencing finds a diagnosis compared to older methods. The goal is to improve future testing and close diagnost…

This study creates a registry for people with leptomeningeal disease, a rare condition where cancer spreads to the lining of the brain and spinal cord. Researchers will collect information on how the disease progresses, what treatments are used, and any side effects. The goal is …

This study compares women with PMDD, major depressive disorder (MDD), and healthy controls to see how their brains, stress responses, and inflammation differ. Researchers will use brain scans, stress tasks, and blood/saliva tests in 75 naturally cycling women aged 18-40. The goal…

This study follows 300 people with a rare genetic movement disorder called SCA27B, along with some family members and healthy volunteers, for up to 2 years. Researchers will use exams, digital devices, and blood tests to measure how the disease changes over time. The goal is to f…

This study is for women with triple-negative breast cancer, either early-stage or advanced, who are receiving immunotherapy. Researchers want to see if changes in a simple blood marker called CRP can predict how well the treatment works. The goal is to find a way to personalize t…

This study looks at whether changes in a blood marker called CRP can help predict how well immunotherapy works in women with advanced gynecologic cancers (cervical, endometrial, ovarian, or vulvar). Researchers will track CRP levels in 120 women receiving immunotherapy plus chemo…

This study looks at how the menstrual cycle and preoperative hormone therapy affect a marker called Ki67 in women with early hormone-positive breast cancer. Researchers will also see if adding a genetic test (PAM50) changes treatment recommendations. About 504 women will particip…

This study is collecting blood and tumor samples from 13,500 breast cancer patients, both early-stage and advanced/metastatic. The goal is to discover biomarkers that can predict how well a treatment will work and to improve overall healthcare quality. Researchers will analyze ge…

This study looks at electrical signals from surgical tools during different types of surgery. Researchers want to see if each surgery type creates a unique pattern, like a digital fingerprint. About 160 adults having certain gynecologic or breast surgeries will take part. The goa…

This study follows about 185 patients with anorexia or bulimia during inpatient weight rehabilitation to see how their stomach and gut symptoms change over time. Researchers will compare three diet types—flexitarian, vegetarian, and vegan—to find out which is linked to fewer dige…

This study will follow 3,000 adults aged 40-80 who are at high risk for heart problems and are having non-cardiac surgery. Researchers want to learn how anesthesia and surgery factors, like blood pressure changes and surgery length, may lead to heart injury. The goal is to find w…