New hope for kids with tough leukemia: antibody drug tafasitamab enters trial

NCT ID NCT05366218

Recruiting now Disease control Sponsor: University Hospital Tuebingen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a drug called tafasitamab in children aged 3 to 17 with B-cell leukemia that has come back or not responded to treatment. The drug is an antibody that helps the immune system find and kill leukemia cells. The trial has two parts: first, finding the best dose, and second, seeing how long it keeps the cancer from returning. Only 20 children will take part, all of whom have already had a stem cell transplant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tafasitamab (a lab-made antibody that helps the immune system attack cancer cells)
What this could lead to: If it works, this could offer a new treatment option for children with hard-to-treat leukemia who have already had a stem cell transplant.
What could go wrong: This is an early-phase trial with only 20 children, so results are uncertain. The drug may not work or could cause side effects like infusion reactions or infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia B-cell acute lymphoblastic leukemia B-cell childhood acute lymphoblastic leukemia Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOCYTIC LEUKEMIA REFRACTORY ACUTE LYMPHOID LEUKEMIA RELAPSE ALL, CHILDHOOD B-CELL

Contacts and locations

Locations

Klinik für Kinder- und Jugendmedizin
RECRUITING

Ulm, Baden-Wurttemberg, 89070, Germany
Klinikum Dr. von Haunersches Kinderspital
NOT_YET_RECRUITING

München, Bavaria, 80337, Germany
University childrens Hospital
RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
Universitäts-Kinderklinik
RECRUITING

Würzburg, 97080, Germany
Universitätsklinikum
NOT_YET_RECRUITING

Essen, 45147, Germany
Universitätsklinikum Düsseldorf
RECRUITING

Düsseldorf, North Rhine-Westphalia, 40225, Germany
Universitätsklinikum Freiburg
RECRUITING

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel
RECRUITING

Kiel, 24105, Germany
Universitätsklinikum, Klinik für Kinder- und Jugendmedizin
NOT_YET_RECRUITING

Frankfurt, 60590, Germany
Universitätsmedizin Berlin, Campus Virchow Klinikum
RECRUITING

Berlin, 13353, Germany
Zentrum für Geburtshilfe, Kinder- und Jugendmedizin
RECRUITING

Hamburg, Free and Hanseatic City of Hamburg, 20246, Germany

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