University Hospital, Toulouse

This study tests whether treating children with uncomplicated appendicitis using antibiotics alone works as well as surgery. About 724 children aged 5 to 15 will be randomly assigned to receive either antibiotics or an operation. The goal is to see if the antibiotic approach lead…

This study tests two low doses of rapamycin, a drug usually used to prevent organ rejection, in 25 teenagers (ages 12-17) with familial adenomatous polyposis (FAP), a genetic condition that causes many colon polyps and raises cancer risk. The main goal is to see if the drug is sa…

This pilot study tests a new care pathway for people with epilepsy who are starting or switching anti-seizure medication. The program combines remote monitoring software with support from a nurse to help patients manage their treatment and detect side effects or seizure changes e…

This study tests whether an artificial intelligence (AI) program that gives personalized diet and exercise advice can help people with non-alcoholic fatty liver disease (NAFLD) reduce liver fat more than standard lifestyle counseling. About 216 adults with NAFLD and overweight wi…

This Phase 3 trial tests whether adding avacopan to standard treatment helps people with severe ANCA vasculitis and serious kidney damage. About 130 participants will receive either avacopan or a placebo alongside usual care. The goal is to see if more patients recover kidney fun…

This study looks at whether simple eye-tracking tests and brain scans can detect very early signs of Alzheimer's disease in 100 healthy older adults. Half of the participants carry a genetic risk factor (APOE4). The goal is to find biomarkers that could lead to earlier diagnosis,…

This study aims to see if a special MRI scan can accurately diagnose invasive upper urinary tract tumors. About 178 adults with suspicious findings on a CT scan will receive an MRI, and the results will be compared to standard biopsy or follow-up CT. If successful, MRI could offe…

This study tests whether eating all meals within an 8-hour window (between early morning and early afternoon) combined with morning exercise can prevent sarcopenia—age-related muscle loss—in postmenopausal women with obesity and type 2 diabetes. Forty-five women will follow eithe…

This study tests whether using a TENS device before a back injection can lower pain during the procedure. About 52 adults with chronic low back pain will be randomly assigned to receive either active TENS or a sham TENS. Researchers will compare pain scores and satisfaction betwe…

This study tests whether applying a lavender oil blend to the skin around the surgical area can improve recovery quality after lung surgery. Researchers will compare the lavender oil to plain almond oil in 124 adults. The main goal is to see if aromatherapy helps reduce pain and …

This study tests whether injecting botulinum toxin (Botox) into the hands or feet can help people with Buerger's disease, a rare condition that blocks blood flow and causes severe pain. Eight adults with critical limb ischemia will receive a single injection session and be follow…

This study tests a hearing rehabilitation program called Hear2Share for elderly people in nursing homes who have hearing loss. The program uses a simple hearing device and is run by nursing home staff. Researchers will measure how well participants can hear words and how often th…

This pilot study will test whether two intravenous infusions of ketamine, given 24 hours apart, can quickly reduce symptoms in 38 adults with severe borderline personality disorder (BPD). Participants also receive standard psychiatric care. The main goal is to see if symptoms imp…

This study tests whether clinical hypnosis and self-hypnosis can reduce hot flashes and improve quality of life in menopausal women who cannot or choose not to take hormone therapy. About 94 women will be split into two groups: one receiving hypnosis sessions and the other receiv…

This study compares hypnosis, virtual reality, and standard care to see which best reduces anxiety in adults starting chemotherapy for acute myeloid leukemia. About 99 patients will be randomly assigned to one of three groups. The goal is to find a non-drug way to help patients c…

This study tests whether injections of stem cells from donated fat tissue can help loosen mouth fibrosis in people with systemic scleroderma. Fifty adults with limited mouth opening will receive either stem cell or placebo injections around the mouth and be followed for 24 weeks.…

This study tests whether intensive music-based rhythm training can improve attention, thinking, and reading in children aged 8 to 10 with complex neurodevelopmental disorders (like ADHD plus dyslexia). Six children will take part in a structured program, and researchers will meas…

This study measures how children ages 7 to 15 with normal hearing understand speech in realistic noisy environments, like a school cafeteria or playground. Using a 360-degree sound system, researchers play sentences in different background noises to see how well kids repeat them.…

This study collects blood, tissue, and other biological samples from adults who have been exposed to, are at risk of, or are diagnosed with an emerging infectious disease. The goal is to create a ready-to-use resource for researchers to better understand how these infections work…

This study looks at how well platelets work in patients on a life-support machine called ECMO, which helps people with severe lung or heart problems. The goal is to understand why these patients often have dangerous bleeding. Researchers will measure platelet function over time a…

This study aims to translate and adapt an English scale (EmNSA) into French to better assess sensation in the legs of adults with acquired brain injury. Researchers will test the new French version on 50 patients to ensure it is accurate and reliable. The goal is to provide a val…

This study looks at 117 people who had a brain bleed (intracerebral hemorrhage) to understand how inflammation and damage to the brain's protective barrier affect recovery. Participants will get special brain scans and blood tests about 10 days after the bleed. The goal is to lin…

This pilot study will test a flexible, home-based care pathway for 100 people newly diagnosed with Parkinson's disease and their caregivers. The program includes questionnaires and educational tools to help patients and families better understand the disease and manage their care…

This study looks at whether cannabis byproducts can be found in the sweat of young children (3 months to 3 years) who come to the emergency room with acute cannabis poisoning. Researchers want to know if sweat contamination might affect hair tests used to check for past exposure.…

This study follows 209 adults aged 65 and older who are hospitalized for neurosurgery in France, Spain, or Portugal. Researchers will measure changes in their ability to perform daily activities (like bathing, dressing, eating) from before surgery to 3 months after. The goal is t…

This study looks at how brain processes like attention and inhibition help people adapt after hearing loss. Researchers will use EEG to measure brain waves in 90 adults receiving cochlear implants, comparing them to normal-hearing participants. The goal is to find brain markers t…

This study will survey 200 adults with Fabry disease to understand how men and women experience different paths to diagnosis. Researchers want to see if symptoms or family screening lead to diagnosis more often in one sex, and how long diagnosis takes. The goal is to identify pat…

This study looks at whether a new observation grid can help doctors and therapists consistently identify early signs of developmental problems in very premature babies (born at 27-32 weeks). Researchers will film 35 infants at home and have different professionals rate their deve…

This study will test whether artificial intelligence (AI) can predict how Parkinson's disease will progress and how patients will respond to medication. One hundred people with Parkinson's will wear a smartwatch and use a mobile app for one year. The AI models will analyze data f…

This study compares a standard high-field MRI with a portable low-field MRI to see if the portable version can detect brain damage in people in a coma after cardiac arrest. Researchers will scan 60 participants (30 coma patients and 30 healthy volunteers) multiple times over two …

This study aims to better understand which brain areas handle tasks like memory, language, and perception. 120 patients with brain tumors will perform short cognitive tests before and during awake surgery. By comparing test results, researchers hope to create a map of brain regio…

This study will check how common it is for obese people with sleep apnea to still have low breathing at night even when using a CPAP machine. About 139 adults will wear a special skin sensor that measures oxygen and carbon dioxide levels overnight. The goal is to find out how man…