Universitätsklinikum Hamburg-eppendorf

This study compares giving norepinephrine continuously versus as needed to prevent low blood pressure during anesthesia in high-risk non-cardiac surgery patients. About 446 adults aged 45 and older with certain risk factors will participate. The goal is to see which method better…

This study tests whether starting heart rhythm control therapy soon after a stroke can prevent future strokes, heart-related deaths, or hospital stays in people with atrial fibrillation. About 1,746 participants will receive either early comprehensive treatment or usual care. The…

This study tests a combination of two drugs, belantamab mafodotin and venetoclax, with or without dexamethasone, in people whose multiple myeloma has come back and is hard to treat. The cancer must have a specific genetic change called t(11;14). The goal is to find the safest dos…

This study tests whether awake patients with acute breathing failure who lie face down (prone positioning) for at least 10 hours a day for 3 days are less likely to need a breathing tube or die within 28 days, compared to standard care. The trial will include 342 intensive care u…

This study tests whether raising blood levels of a natural molecule called beta-hydroxybutyrate (BHB) — through a strict ketogenic diet or ketone drinks — is safe and can improve the effectiveness of immunotherapy (CAR-T cells or bispecific antibodies) in 45 adults with multiple …

This study tests a non-invasive device that delivers mild electrical stimulation to the cerebellum, timed precisely to each patient's hand tremor rhythm. Ten people with Parkinson's and moderate-to-severe hand tremor will receive both real and sham stimulation to see if the real …

This study tests whether a short bout of cycling exercise right before immunotherapy (nivolumab and ipilimumab) can boost the immune system and improve treatment outcomes in people with advanced melanoma. Researchers want to see if this approach is practical and safe for patients…

This study tests a new short-term psychotherapy called ORPHYS, designed to help people with advanced cancer who feel hopeless, lonely, or fearful about the future. 160 patients will be randomly assigned to either ORPHYS or standard psychological support. The goal is to see if ORP…

This registry tracks 2,000 adults with congenital heart disease who are on the waiting list for a heart or heart-lung transplant. The goal is to understand why some patients get worse or die while waiting, while others improve enough to be removed from the list. By collecting dat…

This study investigates whether the quality of parent-adolescent communication at the start of psychiatric inpatient treatment predicts how much symptoms improve six months later. Researchers will track 60 adolescents hospitalized for depression, anxiety, or other mental disorder…

This study looks at how a stroke can disrupt the body's automatic functions, like heart rate and blood pressure control. Researchers will compare 100 people who had a stroke or a mini-stroke using brain scans, blood tests, and heart function tests. The goal is to understand why t…

This registry is following 1,000 patients with a leaky mitral valve (mitral regurgitation) who undergo a minimally invasive procedure called transcatheter mitral valve replacement (TMVR). The goal is to see how well the procedure works in everyday medical practice, including how …

This study is observing 1,000 people hospitalized with acute heart failure to learn how to better predict their outcomes. Researchers will use blood tests, imaging, and other measurements to identify different patient types. The goal is to improve future treatment and care for th…

This study compares continuous vital sign monitoring to standard nurse spot-checks for patients recovering from non-cardiac surgery on regular hospital wards. Researchers want to see if constant monitoring reduces the time patients spend with abnormal vital signs in the first 48 …

This study brings together health data from about 3 million people across 40 countries to see how common risk factors like high blood pressure, smoking, and diabetes affect heart disease and death rates. Researchers want to understand how these risks differ by region and sex. No …

This study follows 1,000 hospitalized adults with acute kidney injury to understand how kidneys recover and what long-term problems may arise, such as chronic kidney disease, heart issues, or dementia. Researchers will compare patients with kidney injury to those without to ident…

This international registry collects medical data and biological samples from children and adults with rare brain tumors like medulloblastoma and ependymoma. By gathering information from patients not in clinical trials, researchers hope to improve treatment recommendations and i…

This study is testing a new online learning tool designed to help people with cancer improve their ability to find and understand health information on the internet. About 660 cancer patients will take part, and they will be randomly assigned to use the online tool, read a PDF wi…