The Hospital For Sick Children

This study tests whether deep brain stimulation (DBS) can reduce severe, repeated self-injury in children with autism. About 25 children aged 5-17 will receive DBS to a brain area linked to reward and behavior. The goal is to control the harmful behavior, not cure autism, and chi…

This study tests whether metformin, a common diabetes drug, can help repair nerve damage in children and young adults (ages 10-25) with multiple sclerosis. Participants take metformin daily for 3 to 9 months, and researchers monitor safety, tolerability, and changes in vision and…

This study aims to improve how doctors diagnose bronchiolitis obliterans syndrome (BOS) in children who have had a stem cell transplant. Researchers will use special MRI scans with xenon gas and advanced breathing tests to see if they can detect BOS earlier and more accurately th…

This early-stage study tests whether an oral supplement called L-Citrulline is safe for preterm infants born at or before 30 weeks who have lung disease (BPD), sometimes with high blood pressure in the lungs (PH), or a serious gut condition (NEC). The goal is to see if raising lo…

This study looks at whether a Mediterranean diet can improve arthritis symptoms in children by changing the bacteria in their gut. Fifty-four children with juvenile idiopathic arthritis will follow the diet for 8 weeks, with an option to continue for 4 more weeks. Researchers wil…

This study tests whether a special nerve block (PECS) given before surgery can lower the need for strong painkillers after implanting a heart device in children aged 3-18. Half the kids will get the nerve block plus standard numbing, the other half only standard numbing. The goal…

This study tests whether adding olanzapine, a safe and inexpensive drug already used in children for other conditions, to standard anti-nausea medicines can better control vomiting in children receiving strong chemotherapy. About 200 children with cancer or undergoing stem cell t…

This study tests whether a computer model (machine learning) can help prevent vomiting in children being treated for cancer. About 1,332 children admitted to the hospital will have their risk of vomiting in the next 96 hours predicted daily. Pharmacists will then alert the medica…

This study tests an online program that helps parents of children with congenital heart disease (ages 3-9) improve their parenting skills and manage child behavior. About 382 families from SickKids in Ontario will take part. The program offers step-by-step support through virtual…

This study tests two new types of lung MRI (using special gases) to see if they can better show lung problems in people with cystic fibrosis or asthma. About 30 people aged 8 and older, including healthy volunteers, will have scans to compare lung structure and function. The goal…

This study tests whether a machine learning model can predict which children will need a targeted medication in the next three months. The goal is to help doctors order pharmacogenetic testing beforehand, so they can choose the right drug or dose. About 275 children aged 6 months…

This study looks at how much of four essential amino acids (isoleucine, leucine, valine, and tryptophan) premature babies need when they get all their nutrition through an IV (called TPN). Researchers will test 80 stable newborns in Brazil using breath and urine samples to find t…

This study is testing whether a machine-learning model can help doctors identify children admitted to the hospital for heart problems who might benefit from a palliative care consultation. The model will flag high-risk patients each morning, and doctors will decide whether to ref…