The Children's Hospital Of Zhejiang University School Of Medicine

This early-phase trial tests a single infusion of universal CAR-T cells (RD06-05) in 30 children and adolescents with severe autoimmune diseases, including lupus, scleroderma, and kidney inflammation. The cells are designed to target and calm overactive immune cells. The main goa…

This study tests a cream called ruxolitinib on children aged 2 to 11 with a common type of vitiligo (white patches on skin). The goal is to see if the cream can safely bring back skin color over 24 weeks. About 20 children will apply the cream daily and visit the clinic for check…

This study tests a family-empowered pulmonary rehabilitation program for school-age children (6-12 years) with asthma. The program includes education, skills training, and home-based guidance. Researchers will compare it to standard care in 92 children to see if it improves asthm…

This study tests whether giving the numbing drug lidocaine during heart surgery can reduce lung damage in infants. 320 babies under 1 year old having heart surgery will receive either lidocaine or a placebo. The goal is to see if lidocaine lowers the severity of lung injury after…

This study aims to see if using a child's genetic information to decide the dose of a chemotherapy drug (6-MP) can reduce dangerous side effects like low white blood cell counts and infections. About 110 children with acute lymphoblastic leukemia will receive a personalized dose …

This study tests a drug called Telitacicept in 30 children with ocular myasthenia gravis, a condition that causes droopy eyelids and double vision. The drug aims to reduce relapses and the need for steroids. It is given as a weekly shot alongside standard care. The trial is open-…

This study looks at whether the timing of a lung washing procedure (bronchoalveolar lavage) helps children with severe pneumonia recover faster. About 3,168 children will receive standard care plus the procedure at different times. Researchers will track how quickly they need les…

This large trial studies over 2,300 very preterm infants (born before 29 weeks) to see whether supplementing mother's milk with pasteurized donor milk or preterm formula improves survival without severe necrotizing enterocolitis (NEC), a dangerous gut condition. It also tests whe…

This study will compare two treatments for children with moderate to severe Crohn's disease: infliximab alone or infliximab plus azathioprine. About 154 children will receive one of the two regimens for over a year. The goal is to see if the combination leads to higher remission …

This study compares two surgical techniques to correct severe penile curvature in children with hypospadias. The standard method uses a flap from the scrotum, which can cause extra surgery time and complications. The new method uses tissue from the urethra itself, aiming for a si…

This study looks at whether the drug telitacicept works better than standard steroids for children aged 3-17 with kidney inflammation caused by IgA vasculitis. About 300 participants will be followed for up to 48 weeks to see if their urine protein levels drop and kidney function…

This study tests whether a new system using cameras to track an ultrasound probe can help doctors find kidney stones faster in children undergoing shock wave lithotripsy. Eighty children with upper urinary tract stones will be randomly assigned to either the new camera-assisted m…

This study looks at whether a blood test for a substance called copeptin can help doctors diagnose and classify bedwetting in children aged 5-18. Currently, diagnosis relies on a detailed urine diary, which is inconvenient and error-prone. The researchers will compare copeptin le…

This trial will test an artificial intelligence system designed to interpret routine newborn screening tests for inherited metabolic disorders. Researchers will compare the AI's accuracy to standard manual review by trained staff. The study plans to include 200,000 newborns in Ch…

This study tests two different ways of giving the steroid dexamethasone to very premature babies (born before 30 weeks) who have been on a breathing machine for at least two weeks. The goal is to see which treatment better prevents a serious lung condition called bronchopulmonary…

This study tests whether playing motion-sensing Nintendo Switch games can help children and teens with congenital heart disease become more physically active. Thirteen participants aged 8-18 will wear activity monitors and follow a 12-week exergame program with coaching and suppo…

This study tests a digital exercise program that adapts in real time to help children aged 6 to 12 recover after congenital heart disease surgery. Kids wear a monitor and get personalized exercise prompts and feedback. Researchers will compare their recovery to children receiving…

This early study tests whether inhaling a gas called xenon for 10 minutes a day over 10 days can improve social functioning in children with autism. 72 children aged 4-18 will receive either xenon or a placebo. Researchers will check social skills right after treatment and again …

This study looks at 199 children with type 1 diabetes who have been using insulin for at least 6 months. Researchers will check for skin problems like lumps under the skin (lipohypertrophy) caused by injections. They will also measure fat thickness with ultrasound and ask caregiv…

This study is testing a comprehensive program to help adolescent girls aged 9-17 and their parents make informed decisions about the HPV vaccine. The program includes educational materials, shared decision-making conversations, and reminders. Researchers will compare vaccination …

This study will create a structured follow-up program for 400 children and young adults who have survived blood cancers like leukemia and lymphoma. Researchers want to better track and understand long-term health problems that can appear years after treatment. The goal is to impr…

This study looks at 1,200 preschool children to understand why some get severe tooth decay. Instead of just looking at teeth, researchers will also study family stress, parenting burnout, children's sleep, and diet. The goal is to create a tool that predicts which kids are most a…

This study will follow 330 infants diagnosed with congenital hydronephrosis (kidney swelling) between birth and 6 months of age for three years. Researchers will track whether the condition gets better, stays the same, or worsens using ultrasound scans. The goal is to understand …