State University Of New York At Buffalo

This study tests whether metformin, a common diabetes drug, is safe and helpful for people aged 55–75 with multiple sclerosis (MS). Participants will take metformin or a placebo for 9 months, and researchers will use brain scans and disability tests to see if metformin protects t…

This study tests whether adding a drug called bicalutamide to the standard drug sunitinib can help people with advanced kidney cancer whose cancer has stopped responding to other treatments. The study will include 28 adults and will check for safety and whether the combination sh…

This study tests two different programs to help pregnant women stop using both cigarettes and e-cigarettes. Researchers will enroll 45 low-income mothers-to-be from Western New York who are early in pregnancy. Participants will be placed into one of three groups: quitting both at…

This study tests a program called CVD-FIT for African American adults who struggle to afford enough food. Participants get monthly income supplements, weekly incentives to buy healthy foods, and phone coaching on heart health. The goal is to see if this combination can lower thei…

This study tests whether eating low-protein meals can make cancer immunotherapy more effective. Researchers think a low-protein diet might change the area around tumors and help the body's immune system fight cancer better. The study will enroll 30 adults with advanced solid tumo…

This study tests whether school-based health centers can improve asthma care for children in underserved communities. About 400 children with uncontrolled asthma will receive guideline-based checkups, daily preventive medication at school, and self-management support. The goal is…

This study checks how well a new device called TonoVera measures eye pressure compared to standard tools. It involves 300 adults with glaucoma. The goal is to see if the new device is accurate and easier to use.

This study tests whether adding continuous glucose monitoring (CGM) to the standard Diabetes Prevention Program (DPP) helps adults with prediabetes stick with healthy habits and lower their risk of developing type 2 diabetes. About 214 adults with prediabetes will receive DPP coa…

This study tests whether sniffing isopropyl alcohol (rubbing alcohol) can reduce nausea in children visiting the emergency room. About 84 kids aged 7 and older with nausea will be randomly assigned to inhale alcohol, take standard anti-nausea medicine, or receive a placebo. The g…

This study looks at whether giving the right amount of portable oxygen during exercise helps people with chronic lung diseases like ILD and COPD be more active and feel better in daily life. Researchers will compare two types of oxygen devices and no oxygen at all, each used for …

This study looks at whether a numbing shot (hematoma block) with either a tiny dose of ketamine or a nasal spray (fentanyl) can control pain as well as full sedation in children aged 3 to 17 who need a wrist fracture realigned. About 50 kids will be randomly assigned to one of th…

This study tests whether a 16-week hydration program can reduce side effects like nausea and dehydration in people starting GLP-1 medications (such as Ozempic or Wegovy). Researchers will track 30 adults aged 18-60 who recently started the drug, measuring hydration levels and sid…

This study looks at whether intermittent fasting (with an optional plant-rich diet) is practical for men with prostate cancer who are receiving hormone therapy. About 30 participants will try the diet, and researchers will track how many sign up, stick with it, and follow the pla…

This study tests a 24-week community program for adults aged 60 and older. Participants will take part in group art activities and dual-task exercise games at a local YMCA. The goal is to see if these fun, social activities can improve thinking skills and physical function. About…

This study explores whether a diet that includes intermittent fasting and plant-based protein can help cancer patients respond better to chemotherapy. About 30 adults with cancer who are eligible for chemotherapy will follow this diet on alternate days before treatment. The main …

This study tests whether vagus nerve stimulation (VNS) paired with rehabilitation can improve leg and walking function in people who have had an ischemic stroke. Researchers will enroll 24 adults who are already approved for VNS therapy for arm problems. The goal is to see if thi…

This study tests whether toothbrushes with tapered bristles are better at removing plaque and reducing gum bleeding than standard round bristles, without causing scratches. About 70 adults with gum disease will use one of two toothbrush types at home for 4 weeks. Researchers will…

This study tests a non-invasive brain stimulation method called transcranial direct current stimulation (tDCS) in children aged 10-15 who have had a mild traumatic brain injury (concussion) and still have symptoms like trouble with movement or thinking. The goal is to see if tDCS…

This study tests whether a noninvasive brain stimulation method, combined with hand exercises, can improve grasping ability in people with chronic spinal cord injury. About 54 adults with neck-level injuries will receive either real or sham stimulation during training sessions. T…

This study tests a brief, 4-session cognitive behavioral treatment (CBT) for people with urological chronic pelvic pain syndrome (UCPPS), including interstitial cystitis and chronic prostatitis. The goal is to reduce pain and improve quality of life. Researchers will enroll 240 a…

This study tests whether starting personalized aerobic exercise soon after a concussion helps active-duty military members recover faster and avoid long-term symptoms. About 168 participants will either receive exercise plus standard care or standard care alone. The goal is to se…

This study looks at what happens when people with schizophrenia stop using nicotine, either from vaping or smoking cigarettes. Researchers will measure mood, cravings, and thinking skills in 64 participants. The goal is to better understand withdrawal and help create better ways …

This pilot study looks at whether it's possible to measure and improve sleep and body clock rhythms in 30 children aged 3 to 6 who are in the pediatric intensive care unit (PICU). Researchers will use a watch-like device and saliva tests to track sleep patterns. They will also tr…

This study tests whether a program called Military PAIRS, where Navy members work in pairs to support each other, can reduce sexual violence and risky drinking. About 132 active-duty U.S. Navy members who drink heavily will take part. They will answer questions about their experi…

This study follows 600 black and white adults with solid tumor cancer to see how cannabis use affects pain, opioid use, and quality of life. Participants use a smartphone app to report their symptoms daily for a year. The goal is to understand if cannabis helps reduce pain and op…

This study aims to find the best work/rest schedule for soldiers in hot weather, so they can finish missions faster without overheating or getting too tired. Researchers will measure body temperature, strength, and heart rate in 24 healthy, active adults during exercise in the he…

This study watches 250 children from BIPOC and low-income families to see how their food preferences, physical activity, and choices change over three years. Researchers measure weight, body fat, and growth to understand links to obesity. No treatment or medication is given—just …

This study looks at whether community pharmacies in under-resourced areas can help people find resources for social needs like food, housing, and transportation. About 1,600 adults will take part. The goal is to see if this help reduces hospital stays and emergency room visits ov…

This study looks at how cannabis use affects symptoms like pain, sleep, and anxiety in cancer patients receiving immunotherapy. Researchers will follow 450 adults over a year using surveys and daily check-ins. The goal is to better understand the benefits and risks of cannabis fo…

This study looks at why older adults have a weaker immune response to the pneumococcal vaccine (Prevnar-13) compared to younger people. Researchers will measure how well neutrophils—a type of white blood cell—kill pneumonia bacteria in blood samples from 60 healthy volunteers age…

This study looks at whether patients in the ICU who need a tracheostomy (a breathing tube in the neck) can safely receive nutrition right up until surgery instead of stopping 6 hours before. The goal is to see if this approach increases food intake without raising the risk of foo…

This study looks at how diet affects blood sugar in 40 night-shift EMS providers who have worked nights for at least a year. Researchers will test a special meal plan to see if it helps control blood sugar and if workers can stick with it. Participants must not have diabetes or o…

This study looks at what happens when daily vapers and cigarette smokers stop using nicotine for a short time. Researchers will measure withdrawal symptoms, cravings, and mood changes in 370 participants. The goal is to better understand nicotine addiction and help develop better…

This study looks at whether a teacher-led program called the Early Childhood Friendship Project can help preschoolers be less aggressive and more kind. About 600 children from diverse backgrounds will take part. Researchers will measure changes in behavior, thinking skills, and e…

This study tests a new imaging device that uses light and sound to check blood flow in foot wounds. The goal is to see if this tool can help doctors decide on better treatments. About 25 people with chronic foot ulcers will take part. This is a small early study to see if the ide…

This study looks at how people with Parkinson's disease learn to understand speech and how that relates to their own speaking ability. Researchers will measure speech clarity, speed, and pauses in 50 participants. The goal is to find links that could lead to new therapies for bot…