Nanfang Hospital, Southern Medical University

This study tests whether combining two types of drugs (EGFR-TKIs and a PD-1 antibody) can help control advanced non-small cell lung cancer with specific EGFR mutations. It involves 32 adults who have not had prior treatment. The main goal is to see how long the cancer stays under…

This study tests whether giving two drugs (anlotinib and bemocizumab) before surgery can improve outcomes for people with resectable esophageal squamous cell carcinoma. About 25 adults with stage II-IIIB disease will receive the combination, then undergo surgery. The main goal is…

This study tests a special plate that dissolves over time, placed during nose surgery to remove pituitary tumors. The plate supports the skull base to prevent spinal fluid leaks, a common complication. About 126 people aged 1 to 80 with sellar tumors will be randomly assigned to …

This study is testing whether combining platelet-rich plasma (PRP) with Botox injections works better than PRP alone for treating androgenetic alopecia (common pattern baldness). About 76 adults aged 18 to 60 with mild to moderate hair loss will receive either the combo treatment…

This study tests a new procedure called EUS-SVD that uses an ultrasound to precisely disconnect blood vessels in the stomach, compared to the standard glue injection method. The goal is to see which approach better prevents re-bleeding from gastric varices in 84 adults over one y…

This study tests a new drug (adebrelimab) combined with standard chemotherapy and radiation for people with advanced or returning esophageal cancer that cannot be removed by surgery. The goal is to see if this combination can shrink or control the cancer better. Thirty adults age…

This study tests a combination of an experimental immunotherapy (QL1706), a blood vessel blocker (bevacizumab), and chemotherapy given directly into the liver artery for people with advanced liver cancer that has caused a clot in the main portal vein. The goal is to see if this a…

This study tests the safety and effectiveness of anlotinib, a drug that blocks blood vessel growth, in 57 adults whose craniopharyngioma has come back after surgery. The main goal is to see if the drug shrinks the tumor. Researchers will also track how long the tumor stays contro…

This study compares a new type of dental crown, called a modified endocrown, to the standard post-and-core crown for fixing large tooth defects after root canal treatment. 246 people with treated premolars will be randomly assigned to get one of the two restorations. The goal is …

This study tests whether adding a targeted drug (like dasatinib or sorafenib) to standard chemotherapy helps people with newly diagnosed acute T-lymphocytic leukemia live longer. About 154 adults will be randomly assigned to get either chemo alone or chemo plus the targeted drug.…

This study tests a new way to create detailed 3D images of lung and colorectal cancer tissue. Researchers will use a special preprocessing system and 3D imaging to get a clearer picture of tumors. The goal is to improve how doctors diagnose and plan treatment for these cancers. T…

This study tests a special fluorescent dye that attaches to cancer cells to help doctors see if lymph nodes contain cancer during surgery for early gastric cancer. About 47 people with early gastric cancer will have their removed lymph nodes examined with this probe. The goal is …

This clinical trial tests whether a doxepin solution spray can relieve severe breakthrough pain when swallowing, a common side effect of radiation therapy for nasopharyngeal carcinoma. About 178 patients will be randomly assigned to receive either the doxepin spray or a placebo s…

This study tests whether mixing an electrolyte beverage with water improves the quality and tolerability of bowel preparation before colonoscopy. 405 adults scheduled for colonoscopy will be randomly assigned to drink polyethylene glycol (PEG) with water only, or with a low or me…

This study looks at two sedatives, ciprofol and propofol, given to ICU patients who need breathing support but are not on a ventilator. The goal is to see which drug works better and causes fewer breathing problems. About 1,680 adults from 30 hospitals in China will be included, …

This study is collecting medical data and tumor or blood samples from 500 adults with malignant tumors treated at a Chinese hospital between 2017 and 2025. Researchers will analyze genes, immune cells, and other molecular features to understand what affects survival and treatment…

This study follows 400 adults with early colorectal cancer whose endoscopic removal was not fully successful (non-curative). Researchers will compare outcomes between those who have additional surgery and those who are simply monitored. The goal is to find better ways to manage t…

This study is developing an artificial intelligence (AI) model to help doctors diagnose cancer more accurately by analyzing pathology slides and patient data. Researchers will collect information from 2000 adults with various cancers to train and test the AI. The goal is to creat…

This study follows 420 adults with Crohn's disease who are in deep remission to see if a non-invasive intestinal ultrasound can predict when symptoms will return. Participants get regular ultrasounds over 18 months, and researchers compare those who relapse to those who don't. Th…

This study aims to understand how liver diseases like fatty liver, hepatitis B, fibrosis, and cirrhosis develop by analyzing individual liver cells and their spatial organization. Researchers will collect blood and discarded liver tissue from 240 patients undergoing surgery or bi…

This study looks at immune cells from lymph nodes, tonsils, and liver tissue of people with chronic hepatitis B. Researchers want to understand how the germinal centers—the parts of the body that train immune cells—respond to the virus. By analyzing these tissues, they hope to le…

This study looks at 3,000 people with type 2 diabetes to see if certain signs of inflammation in the blood are linked to diabetes-related health problems. Researchers hope to find early clues that could help identify patients at higher risk for complications. The study is purely …

This study follows 800 adults with type 2 diabetes to see how their lifestyle choices relate to long-term complications like heart or kidney problems. Researchers will track participants over time and record any complications that develop. The goal is to find early warning signs …

This study looks at why people with chronic kidney disease (CKD) often lose muscle mass and strength, a condition called sarcopenia. Researchers will follow 1,000 adults with CKD to find risk factors for sarcopenia and see how it affects their health over time. The goal is to bet…

This study looks at whether a patient's emotional state—like depression or anxiety—affects how well advanced liver cancer treatment works. Researchers will follow 90 people with liver cancer who are getting a combination of chemotherapy, targeted therapy, and immunotherapy. They …

This study looks back at medical records of 1,500 ICU patients with sepsis and low platelet counts to see if those who received platelet transfusions had better survival at 28 days. The researchers also track bleeding and blood clot risks. Because it is observational, it can only…

This study tests whether an artificial intelligence (AI) model can accurately predict genetic changes in gliomas, a type of brain tumor, using digital images of tissue samples. Researchers will collect pathology images and molecular test results from 2,000 adults with suspected g…

This study looks at how common sleep apnea is in people with chronic kidney disease and whether it makes kidney function worse over time. Researchers will follow 356 adults with moderate kidney disease for several years, tracking their health and sleep patterns. The goal is to fi…

This study will follow 5000 people with chronic hepatitis B who are not on antiviral treatment, aged 1 to 80, for several years. Researchers will take blood samples every six months to track how the immune system responds to the virus as patients age. The goal is to better unders…