Leiden University Medical Center

This study tests if taking mifepristone 50 mg just once a week can prevent pregnancy effectively and safely. About 1,186 women aged 18-35 will use it as their only birth control for one year. The pill contains no hormones, so it may have fewer side effects than daily options.

This study is testing whether giving different amounts of blood thinners based on a person's risk can prevent dangerous blood clots and reduce bleeding after hip or knee replacement. About 10,000 adults having elective hip or knee replacement will be assigned to either standard t…

This study tests whether aerobic exercise or cognitive behavioral therapy can reduce severe fatigue in people with myasthenia gravis, a muscle weakness condition. About 60 adults with stable MG will be randomly assigned to one of these treatments or usual care. The goal is to see…

This study compares two ways of handling nerves during leg amputation to see which better prevents long-term pain. About 200 adults having a leg amputation due to blood vessel disease will be randomly assigned to either standard nerve cutting or a newer technique called targeted …

This study is testing a new imaging technique called laser speckle contrast imaging (LSCI) to monitor blood flow in the legs of 30 people undergoing surgery to restore circulation. The goal is to see if LSCI can provide useful information before, during, and after the procedure. …

This study tests a new online tool designed to help people taking five or more medications understand their drugs better and avoid harmful interactions. About 120 adults from four European countries will use the tool for 12 weeks and answer questionnaires. The goal is to see if t…

This study aims to understand why older adults, especially those who are frail, lose important immune cells (T cells) from their nasal passages, making them more prone to lung infections. Researchers will compare nasal and blood samples from 170 healthy young adults, healthy olde…

This study observes 60 ICU patients on breathing machines to measure how hard they work to breathe and how much oxygen they use. Researchers want to see if a special device can predict which patients will have trouble breathing on their own. The goal is to better understand why s…

This study checks if a simple finger-prick blood test (dried blood spot) can accurately measure levels of certain cancer drugs in the body. Researchers will compare results from the finger-prick method with standard blood draws. If successful, patients may be able to monitor thei…

This international registry is gathering real-world data on how SGLT2i medications are prescribed to adults with congenital heart disease. Researchers will track 400 participants to understand usage patterns, side effects, and potential benefits for heart failure. The goal is to …