Leiden University Medical Center

This study tests a combination of two immunotherapy drugs (ipilimumab and nivolumab) plus a chemotherapy drug (melphalan) given directly to the liver for people with advanced uveal melanoma that has spread, especially to the liver. The goal is to see if this approach is safe and …

This study tests whether a sleep-deepening drug (lower-sodium oxybate) or a nerve stimulation device (non-invasive vagus nerve stimulation), or both, can help the brain clear harmful proteins in people with cerebral amyloid angiopathy (CAA). Sixty adults with CAA will receive one…

This study looks at how inflammation in the brain affects people with frontotemporal lobar degeneration (FTLD), a group of disorders that cause dementia. Researchers will use powerful MRI scans and tests on blood and spinal fluid to measure inflammation and brain changes. The goa…

This study looks at whether a team-based, proactive care plan can help people with multiple health and social problems who frequently use emergency services. Researchers will compare costs and quality of life for 200 patients receiving this integrated care versus usual care. The …

This study follows 120 people with and without early Alzheimer's to track how blood vessel function in the brain changes over time. Using special MRI scans, researchers measure the brain's response to visual stimulation. The goal is to better understand how small blood vessel dis…