Leiden University Medical Center

This study tests a once-weekly pill (mifepristone 50 mg) as a contraceptive for women aged 18-35. Over 600 participants will use it for one year to see how well it prevents pregnancy and whether it causes fewer side effects than daily hormone-based birth control. The pill does no…

This study tests whether a sleep medication (lower-sodium oxybate) or a gentle nerve stimulation device, or both, can help the brain flush out harmful proteins in people with cerebral amyloid angiopathy (CAA). Sixty adults with CAA will be randomly assigned to one of the treatmen…

This study tests a combination of two immunotherapy drugs (ipilimumab and nivolumab) plus a chemotherapy drug (melphalan) given directly to the liver for people with advanced uveal melanoma that has spread, especially to the liver. The goal is to see if this approach is safe and …

This study looks at whether customizing the length of blood thinner treatment based on a person's individual risk of another clot or bleeding can improve outcomes. About 600 adults who had a first blood clot (deep vein thrombosis or pulmonary embolism) will fill out a questionnai…

This observational study looks at how brain inflammation contributes to frontotemporal lobar degeneration (FTLD), a group of rare brain disorders. Researchers will use advanced MRI scans, blood tests, and spinal fluid samples from 110 participants to track changes over time. The …

This study looks at whether bacteria from throat swabs, stool, and lung samples can help predict which patients with stage III lung cancer will have their cancer return during immunotherapy (durvalumab) after chemoradiation. Researchers will also study how antibiotics affect trea…

This study looks at whether a personalized risk assessment tool called PERSARC can help patients with soft-tissue sarcoma understand their treatment options better and feel less conflicted about their decisions. About 120 adults with high-grade sarcoma in their arms or legs will …

This study follows 500 adults with uveal melanoma (a rare eye cancer) to measure how diagnosis and treatment affect their quality of life, mental health, and decision-making. Participants complete surveys before treatment and for five years after. The goal is to better understand…

This study looks at whether a team-based, proactive care plan can help people with multiple health and social problems who frequently use emergency services. Researchers will compare costs and quality of life for 200 patients receiving this integrated care versus usual care. The …

This study follows 120 people with and without early Alzheimer's disease to track how blood vessel function in the brain changes over time. Using special MRI scans, researchers measure the brain's response to visual stimulation. The goal is to better understand how small vessel d…