New combo therapy targets liver tumors in rare eye cancer

NCT ID NCT04283890

First seen Sep 30, 2025 · Last updated May 19, 2026 · Updated 30 times

Summary

This study tests a combination of immunotherapy drugs (ipilimumab and nivolumab) plus a chemotherapy drug (melphalan) given directly to the liver for people with advanced uveal melanoma that has spread, especially to the liver. The goal is to see if this approach is safe and can help control the cancer in both the liver and other organs. About 83 adults aged 18-75 with no prior systemic treatment are participating.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Leiden University Medical Center

    Leiden, South Holland, 2333 ZA, Netherlands

Conditions

Explore the condition pages connected to this study.