Guy's And St Thomas' Nhs Foundation Trust

This study tests whether lactoferrin, a natural prebiotic from cow's milk, can be a good alternative to antibiotic tablets for women with bacterial vaginosis (BV) or thrush. Researchers will recruit 114 women and give half lactoferrin vaginal pessaries for 3 weeks, while the othe…

This study is testing two different procedures—AF catheter ablation and AV node ablation—in 70 people who have heart failure, atrial fibrillation, and a CRT device that isn't pacing enough. The goal is to see which procedure better improves heart function and quality of life afte…

This pilot study is testing whether a light-activated gel applied inside the nose before surgery can prevent infections afterward. Eighty adults having nasal surgery will either get the light treatment or a plain gel. Researchers will track who needs antibiotics for infection wit…

This study tests a new type of breathing machine (volume-targeted ventilation) for people with slowly worsening muscle diseases who already use a standard breathing machine at night. The goal is to see if it can better control carbon dioxide levels and improve sleep comfort. Abou…

This trial tests whether a set of three virtual-reality games, called BEARS, can improve hearing in noisy places for children aged 8 to 16 who have two cochlear implants. The games train the brain to pick out speech from background noise, locate where sounds come from, and enjoy …

This study tests a new NHS pathway to help adults with type 1 diabetes manage diabetes distress—the worry, frustration, and burnout that often comes with the condition. The pathway trains healthcare teams to recognize and discuss distress during routine visits, and offers an onli…

This study tracks quality of life in 200 adults with chronic respiratory failure who use breathing support like non-invasive ventilation. Researchers will use questionnaires to see how treatments impact daily living over time. The goal is to better understand patient experiences,…

This study looks at how to best use a machine that helps people with neuromuscular disease cough and clear mucus from their lungs. Researchers will test different pressure settings to see which works best without causing side effects. About 30 adults with stable or slowly progres…

This study aims to better understand asthma and COPD by comparing immune markers in blood and airways of patients versus healthy volunteers. Researchers will analyze samples from 230 adults to identify distinct immune patterns linked to disease severity. The goal is to improve di…

This study looks at how different sedatives affect the breathing of patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. Twenty adults in the ICU will receive both standard intravenous propofol and inhaled isoflurane (a gas used in anesthesia) for sho…

This observational study is recruiting 140 people to see if a history of concussions or playing contact sports is more common in those with REM sleep behavior disorder (RBD) compared to those without. RBD causes people to physically act out their dreams. Participants will answer …

This study looks at why people with pleural effusion (fluid around the lungs) feel short of breath. Researchers will measure breathing effort and breathlessness before and after fluid removal in 124 adults. The goal is to better understand the connection, not to test a new treatm…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedat…

Acute kidney injury affects half of ICU patients, often requiring dialysis. This study compares a lower dose of dialysis to the standard dose in 20 critically ill adults. The goal is to see if the lower dose is safe and effective, and to inform a larger future trial.