Guy's And St Thomas' Nhs Foundation Trust

This study tests whether adding a special anti-inflammatory mouthwash to a deep-cleaning procedure helps heal advanced gum disease better than the cleaning alone. About 20 adults with severe gum disease will be randomly assigned to use either the active mouthwash or a placebo for…

This study compares two devices—the Fetal Pillow (an inflatable balloon) and the Tydeman Tube (a manual tool)—used to lift a baby's head when it gets stuck during a full-dilatation C-section. Researchers will measure how quickly the baby is delivered and track complications like …

Standard hearing tests often fail in children with autism or social communication disorders because they struggle to engage with beeps and tones. This study tests whether using band-pass filtered familiar music — a child's known song altered to target specific frequencies — can p…

This study will recruit 100 sexual partners of people diagnosed with gonorrhea. Researchers will take an extra throat swab to analyze all the bacteria and their genes using a technique called metagenomics. The goal is to find hidden infections, antibiotic resistance, and see how …

This study will interview and observe up to 15 clinical research nurses and 15 research-patients at a London NHS hospital. The goal is to understand the challenges nurses face balancing patient care with research duties, and how patients feel about taking part in trials. Insights…

This study will compare two newer pacemaker technologies—left bundle branch area pacing and leadless pacing—to see how they affect heart function and the tricuspid valve. Twenty adults with certain heart block conditions will receive both types temporarily during their routine pa…

This study will interview 15 parents or guardians of children with spinal muscular atrophy type 1 to learn about their daily challenges with feeding and communication. Even though newer treatments have improved survival, their impact on swallowing and speech is not well understoo…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This observational study will enroll 50 children in intensive care with suspected pneumonia. Researchers will use a new technology called metagenomics to detect all bugs in the lung, and also measure how the body's cells and proteins respond. The goal is to see if this combined a…

This study looks at how anxiety and depression influence shared decision-making in patients aged 65 and older with critical limb threatening ischaemia (CLTI), a severe form of leg artery disease. Researchers will interview patients, their carers, and healthcare staff to understan…

This study will look at 40 people with both hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF) to understand why AF is more common and harder to treat in HCM. Researchers will measure electrical signals in the heart and use advanced imaging. The goal is to find clues …

This study tests whether a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve how older adults (60+) are evaluated for kidney transplants. Fifty participants will either receive the KT-CGA plus usual care or usual care alone. The goal is to see if …

This study aims to understand why ethnic minority groups in England may not be using genomic medicine services as much as others. Researchers will interview 100 adults, including community members, patients, and healthcare professionals, to gather experiences and ideas. The goal …

This study will interview pregnant and postnatal women who have two or more long-term health conditions, as well as their midwives and other healthcare professionals. The goal is to understand their experiences and challenges with midwifery care. The findings will be used to co-d…

This study looks at whether a protein called Dickkopf 3 (DKK3) in urine can detect kidney transplant problems sooner than standard blood tests. Researchers will collect urine samples from 258 kidney transplant recipients over 12 months and compare DKK3 levels with usual measures …

This study tests whether two widely used anti-platelet drugs, aspirin and clopidogrel, can reduce inflammatory markers in people with silent atherosclerosis (hardening of the arteries without symptoms). Researchers will measure changes in monocyte-platelet aggregates, a sign of i…

This study tests a small device called Seismofit that sticks to the chest and measures heart vibrations to estimate fitness in under three minutes. Researchers want to see if it can predict complications like pneumonia and hospital stay length in 164 oesophageal cancer patients u…