Centre Francois Baclesse

This study compares two approaches for treating intermediate-risk thyroid cancer after surgery. One group gets radioactive iodine as a standard precaution. The other group only gets it if a blood test and scan show signs of remaining cancer. The goal is to see if the selective ap…

This Phase 2 trial tests a new way to give radiation for sinus cancer after endoscopic surgery. Instead of radiating the whole sinus area, doctors will use a 'dose painting' technique that targets only the areas where cancer was found. The goal is to see if this reduces side effe…

This study tests whether a digital app that tracks symptoms weekly can help doctors better manage side effects in people with advanced kidney cancer taking cabozantinib and nivolumab. About 83 patients will use the app to report how they feel, and doctors can adjust treatment bas…

This study tests whether avoiding radiation to the surgical flap (the tissue used to rebuild the mouth after cancer removal) is as effective as standard radiation that treats the whole area. About 348 adults with oral cavity cancer who had reconstructive surgery will be randomly …

This study compares two types of radiation for people with up to 5 brain metastases from solid tumors. One group gets a single high dose of radiation, the other gets three smaller doses over a week. The goal is to see which approach better controls tumors and causes fewer side ef…

This study tests whether high-dose, precise radiation (stereotactic radiotherapy) can control a few growing kidney cancer spots while the rest of the disease is stable on current medication. About 77 people with metastatic kidney cancer whose tumors are progressing in only a few …

This phase 2 trial is testing whether a combination of two drugs, Talazoparib and Avelumab, can help keep advanced urothelial (bladder) cancer from growing after initial chemotherapy. About 50 adults with platinum-sensitive cancer will receive the drugs as maintenance therapy unt…

This study tests whether specially adapted beauty sessions (onco-esthetics) can help people with head and neck cancer feel better about their changed appearance after treatment. Fifty-five patients will receive three sessions, and researchers will measure how their self-image cha…

This study tests whether using a walking platform every day after cancer surgery helps patients aged 65 and older regain their normal walking speed by the time they leave the hospital. Sixty participants will do short walking sessions starting the day after surgery. The goal is t…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve quality of life by reducing digestive symptoms like nausea and bloating during first-line chemotherapy for ovarian cancer. About 116 women will be randomly assigned to receive eit…

This study tests whether online cognitive exercises, guided by a neuropsychologist, can reduce memory and thinking problems (chemo brain) in 300 breast cancer patients after chemotherapy. Participants will do 20-minute brain games three times a week for 12 weeks, with some gettin…

This study aims to grow miniature versions of head and neck tumors, called organoids, from patient samples. Researchers will test different cancer drugs on these organoids to see which ones work best. The goal is to eventually use this approach to tailor treatments to each patien…

This study takes small tumor samples from people with triple-negative breast cancer and grows them in the lab as 3D mini-tumors called organoids. Researchers will test different cancer drugs on these organoids to see which ones work best and look for clues that could predict a pa…

This study looks at whether a special hospital visit with a team of experts can help women who finished treatment for ovarian or endometrial cancer get more of the supportive care they need. About 268 women in remission will be split into groups: some get the extra hospital asses…

This study is testing whether tiny lab-grown copies of a patient's tumor, called organoids, can help predict which cancer treatment will work best. Researchers will collect tumor and blood samples from 20 people with undifferentiated carcinoma before they start standard therapy. …

This study looks at two types of radiation therapy for a slow-growing brain tumor near the cavernous sinus. Researchers want to see if proton therapy causes less long-term harm to thinking and memory than standard photon radiation. About 160 adults aged 18 to 70 will be followed …

This study looks at how sleep disturbances impact thinking skills and quality of life in 75 women treated for breast cancer. Participants will undergo brain scans, sleep tracking, and cognitive tests over six months. The goal is to understand the links between sleep, brain functi…

This study is testing two genetic tests (Giscar and myChoice) to see if they can identify ovarian cancer patients whose tumors have a specific DNA repair problem (HRD). The goal is to see if these tests can predict which patients will respond well to platinum chemotherapy and may…