Centre Francois Baclesse

This study compares two ways of delivering high-dose radiation to people with up to 5 brain metastases from solid tumors. One method gives a single large dose, while the other splits the dose into three smaller sessions. The goal is to see which approach better controls tumor gro…

This study looks at whether having patients report their symptoms weekly through a digital app helps doctors make better treatment decisions. It involves 83 adults with advanced kidney cancer who are starting a combination of two drugs (cabozantinib and nivolumab). The goal is to…

This study tests whether a combination of two drugs, Talazoparib and Avelumab, can help keep advanced urothelial (bladder) cancer from growing after initial chemotherapy. About 50 adults with cancer that has spread will receive this maintenance therapy. The goal is to see if it d…

This study tests a new way to give radiation after oral cancer surgery that avoids treating the surgical flap. The goal is to see if this approach can reduce side effects like mouth and throat problems while still controlling the cancer. About 348 adults who had reconstructive su…

This study compares two ways of treating intermediate-risk thyroid cancer: giving everyone radioactive iodine (RAI) versus using a blood test and scan to decide who really needs it. About 476 adults with papillary, follicular, or Hürthle cell thyroid cancer will take part. The go…

This study is for people with kidney cancer that has spread to a few places and is starting to grow again despite current treatment. Instead of switching to a new drug right away, doctors will use precise, high-dose radiation on the growing spots. The goal is to control those spo…

This study tests whether a supervised online brain-training program can reduce memory and thinking problems (often called 'chemo brain') in breast cancer patients after chemotherapy. About 300 patients will either get the program with a neuropsychologist coach or do the same exer…

This study tests whether a web application can help breast cancer patients better follow their hormone therapy and improve their quality of life. About 438 patients starting hormone treatment will either use the app or receive standard care. The goal is to see if the app makes it…

This study tests whether using a walking platform every day helps people aged 65 and older regain their normal walking speed after cancer surgery. Researchers will compare how many patients recover their pre-surgery walking ability by the time they leave the hospital. The goal is…

This study looks at whether adapted oncoesthetics (special beauty care) can help people with head and neck cancer feel better about their appearance after harsh treatments. About 55 adults starting cancer therapy will receive early oncoesthetics. The goal is to see if this approa…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can improve quality of life, especially digestive issues like nausea and bloating, in people receiving their first chemotherapy for ovarian cancer. About 116 participants will either rec…

This study tests two ways to cool the scalp during chemotherapy to prevent hair loss in women with early-stage breast cancer. About 196 participants will use either a standard cooling cap or a cooling mask. Researchers will compare how well each method works, how patients feel ab…

This study looks at whether a special hospital visit with a team of experts can help women who have finished treatment for ovarian or endometrial cancer get the supportive care they need. About 268 women in remission will either receive a personalized care plan with a day-hospita…

This study looks at 88 women with advanced ovarian cancer to compare two tests that check for a DNA repair problem called HRD. The tests help doctors see if the cancer is likely to respond to platinum chemotherapy and if a PARP inhibitor drug might help. The goal is to learn whic…

This study looks at how sleep problems impact thinking skills and quality of life in 75 women treated for breast cancer. Researchers will track sleep patterns using a wrist monitor and ask participants about their memory and mood. The goal is to better understand these links and …

This study takes small tumor samples from people with triple-negative breast cancer and grows them in the lab as 3D mini-tumors called organoids. Researchers will test different drugs on these organoids to see which ones work best and look for biological markers that predict trea…

This study aims to grow miniature versions of tumors (called organoids) from patients with a rare and hard-to-treat cancer called undifferentiated primary carcinoma. By testing different drugs on these lab-grown organoids, researchers hope to predict which treatment will work bes…

This study looks at two types of radiation for a slow-growing brain tumor near important brain areas. Researchers want to see which method causes fewer long-term problems with memory and thinking. About 160 adults aged 18 to 70 will be randomly assigned to proton therapy or moder…