Centre Francois Baclesse

This study tests whether a web application can help breast cancer patients take their hormone therapy as prescribed. About 438 patients starting hormone therapy will either use the app or receive standard care. The goal is to see if the app improves medication adherence and quali…

This study tests whether adding olaparib, a drug that blocks DNA repair in cancer cells, to standard chemoradiation can improve survival for people with high-grade gliomas that cannot be fully removed by surgery. The trial has two phases: first, finding the safest dose of olapari…

This Phase 2 trial tests a new way of delivering radiation therapy (SIB-IMRT) together with standard chemotherapy (5-FU and Mitomycin-C) for people with locally advanced anal cancer. The goal is to see if this approach can improve tumor control and reduce the severe side effects …

This study aimed to test whether combining special nanoparticles with proton radiation could help control cancers that return after previous radiation treatment. The trial was planned for adults with tumors in specific areas like the skull base or throat. However, the study was w…

This study tests two ways to cool the scalp during chemotherapy to prevent hair loss in women with localized breast cancer. One uses a standard cold cap with a compression bandage, the other a cooling mask. Researchers will compare how well each prevents hair loss, and also look …

This study tests a personalized post-cancer care plan for women who have finished treatment for ovarian or endometrial cancer. About 99 participants will receive a day of support care and a tailored plan to address their needs. The goal is to see if this approach improves their l…

This study examines head and neck cancers that occur during pregnancy or within 12 months after giving birth. Researchers will check for certain viruses (HPV and EBV) and look at tumor types and pregnancy complications. The goal is to better understand these rare cases, not to te…

This study looks at women who have recovered from rare ovarian cancers (germ cell or sex cord-stromal tumors) to understand how the disease and chemotherapy affect their lives years later. Researchers will use questionnaires to measure chronic fatigue, quality of life, and other …

This study tests whether adding a weekly check-in with a radiology technician (called a MERM) to standard doctor visits can better detect side effects in brain tumor patients receiving proton therapy. About 92 adults with brain or upper airway tumors will be randomly assigned to …