Brain radiation face-off: one big dose vs. several smaller ones
NCT ID NCT05102747
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two types of radiation for people with up to 5 brain metastases from solid tumors. One group gets a single high dose of radiation, the other gets three smaller doses over a week. The goal is to see which approach better controls tumors and causes fewer side effects like brain tissue damage. The trial plans to enroll 504 participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiation therapy
- What this could lead to
- If this trial succeeds, it could establish a new standard radiation schedule that reduces side effects like brain tissue damage while still controlling tumors.
- What could go wrong
- This is a phase 3 trial, but it compares two existing treatments, so no breakthrough is expected. The benefit of the new schedule may be small, and some patients may still experience side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU
NOT_YET_RECRUITINGBordeaux, France
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CHU
RECRUITINGBrest, France
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CHU
NOT_YET_RECRUITINGGrenoble, France
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Centre Antoine Lacassagne
NOT_YET_RECRUITINGNice, France
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Centre Eugène Marquis
RECRUITINGRennes, France
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Centre François Baclesse
RECRUITINGCaen, 14076, France
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Centre Guillaume le Conquérant
RECRUITINGLe Havre, France
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Centre Henri Becquerel
NOT_YET_RECRUITINGRouen, France
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Centre d'Oncologie et Radiothérapie Saint-Jean
RECRUITINGSaint-Doulchard, France
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Centre hospitalier Lyon Sud
NOT_YET_RECRUITINGPierre-Bénite, France
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Groupe hospitalier Bretagne Sud
RECRUITINGLorient, France
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Gustave Roussy
NOT_YET_RECRUITINGVillejuif, France
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Institut Bergonié
NOT_YET_RECRUITINGBordeaux, France
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Institut Claudius Regaud
NOT_YET_RECRUITINGToulouse, France
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La Pitié Salpétrière
NOT_YET_RECRUITINGParis, France
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