STAGE IVB LUNG CANCER AJCC V8

This early-phase study tests a combination of all-trans retinoic acid (a vitamin A derivative) and the immunotherapy drug atezolizumab in adults with advanced non-small cell lung cancer that has returned or spread. The main goal is to find the safest dose and understand side effe…

This study looks at whether using focused radiation (stereotactic radiosurgery) only on the brain tumors, instead of the whole brain, can help preserve thinking and memory in people with small cell lung cancer that has spread to the brain. About 55 participants will receive this …

This early trial tests combining the targeted drug brigatinib with local treatments like surgery or radiation for people with advanced ALK-positive non-small cell lung cancer. The goal is to see if this approach is safe and helps control the cancer longer. About 35 participants w…

This study tests a combination of three drugs (niraparib, temozolomide, and atezolizumab) in people with advanced solid tumors or extensive-stage small cell lung cancer that has responded to initial chemotherapy. The goal is to find the safest dose and see if the combination help…

This study tests a combination of the CIMAvax vaccine and nivolumab (an immunotherapy drug) in people with advanced non-small cell lung cancer or squamous head and neck cancer. The goal is to find the best dose and see if the combination helps control tumor growth and improve sur…

This study tests whether a lung cancer drug called atezolizumab can be safely given as a shot under the skin at home, with doctors monitoring patients through video calls. It involves 5 adults with non-small cell lung cancer. The goal is to see if this home-based approach is prac…

This study looks at whether adding surgery or radiation to the targeted drug osimertinib helps people with advanced EGFR-mutant non-small cell lung cancer live longer without their cancer growing. About 173 participants will receive either osimertinib alone or osimertinib plus lo…

This study compares two treatments for lung tumors: microwave ablation (using heat to kill cancer cells) and surgical wedge resection (removing a small piece of lung). It includes adults with non-small cell lung cancer, sarcoma, or colorectal cancer that has spread to the lungs. …

This study tests a mix of drugs (olaparib, durvalumab, carboplatin, etoposide) plus radiation in people with advanced small cell lung cancer that has spread. The goal is to see if this combination is safe and works better than standard treatment. About 63 participants will take p…

This study tests whether adding tocilizumab to standard immunotherapy (ipilimumab and nivolumab) can reduce severe side effects in people with advanced melanoma, lung cancer, or bladder cancer. About 35 participants will receive the combination to see if it is safer and still eff…

This early-phase trial tests a new treatment for people with advanced non-small cell lung cancer that no longer responds to standard immunotherapy. The treatment uses immune cells from donated umbilical cord blood that are genetically modified to better recognize and attack cance…

This early-phase study tests a new drug combination for people with advanced ALK-positive non-small cell lung cancer. The goal is to find the best dose of ensartinib when given with standard chemotherapy and a targeted antibody. About 12 participants will receive the treatment to…

This study tests two drugs together—trametinib and pembrolizumab—in people with advanced non-small cell lung cancer that has returned or spread. The goal is to see if the combination can shrink tumors or slow the cancer's growth. About 37 participants will receive the treatment, …

This early-phase trial tests the safety and best dose of a new drug called minnelide when combined with the standard drug osimertinib for people with advanced EGFR-mutant non-small cell lung cancer. Only 8 participants are enrolled. The goal is to find side effects and the right …

This study tests a drug called selpercatinib in people with advanced or returning non-small cell lung cancer that has a specific gene change (RET fusion). The drug works by blocking signals that help cancer cells grow. About 124 participants will receive the treatment to see if i…

This study tests a combination of three drugs (chemotherapy, anti-angiogenesis, and immunotherapy) in 30 adults with advanced non-small cell lung cancer that worsened after standard treatments. The goal is to see if this triple therapy is safe and works better than current option…

This early-stage trial tests a drug called berzosertib combined with whole brain radiation for people with lung cancer that has spread to the brain. The main goal is to find the safest dose and check side effects. About 15 adults with non-small cell, small cell, or neuroendocrine…

This early-phase trial tests two experimental drugs, sapanisertib and telaglenastat, in people with advanced non-small cell lung cancer that has spread or come back after standard treatments. The main goals are to find the safest dose and see if the combination can shrink tumors …

This study tests a combination of three drugs—osimertinib, trastuzumab, and necitumumab—in people with advanced EGFR-mutated lung cancer that no longer responds to osimertinib alone. About 30 participants will receive the drugs to find the safest dose and see if the combination c…

This early-phase study tests a combination of two drugs, brigatinib and bevacizumab, in people with a specific type of lung cancer (ALK-positive) that has spread or returned after prior ALK-directed therapy. The main goals are to find the best dose and check for side effects. Onl…

This study tests a new drug combination for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). The two drugs, LY3295668 and osimertinib, work by blocking enzymes that help cancer cells grow. The goal is to find the safest dose and see if…

This phase 2 study tests a new drug (pevonedistat) combined with two standard chemotherapies (carboplatin and paclitaxel) in 27 adults with advanced non-small cell lung cancer that has not responded to immunotherapy. The goal is to see if this combination can shrink or control th…

This study tests whether adding N-803 (a natural killer cell booster) to pembrolizumab (an immunotherapy) can help shrink or stabilize advanced non-small cell lung cancer in patients whose previous immunotherapy stopped working. About 82 participants will receive either the combo…

This study tests a drug called AMG 510 in people with advanced lung cancer that has a specific genetic change (KRAS G12C mutation). The drug is designed to block the cancer's growth signal. About 116 participants will receive the treatment to see if it can shrink tumors and slow …

This study looks at whether a drug called anamorelin can help improve appetite and prevent weight loss in people with advanced non-small cell lung cancer who have lost their appetite and are losing weight. About 25 participants will take either the drug or a placebo and share the…

This study tests an online program designed to help women with lung cancer feel more supported and less distressed during treatment. The program uses techniques like mindfulness and emotional processing to improve social well-being. About 70 women with stage I-IV non-small cell l…

This study looks at whether updating radiation treatment plans at set times (adaptive planning) can lower side effects like lung inflammation in people with stage II-IV non-small cell lung cancer. About 34 participants will receive standard radiation and immunotherapy, but their …

This study tests a nurse-led program designed to help people with advanced lung or gynecologic cancer cope with fears about their future. About 42 participants will try the program, which includes sessions and home activities. The goal is to see if the program is practical and he…

This early-stage study tests whether giving a single, very focused dose of radiation after lung cancer surgery is safe and causes fewer side effects than standard weeks-long radiation. It involves 50 adults with non-small cell lung cancer who had surgery but still have cancer cel…

This study tests whether watching a short video helps people with metastatic cancer understand what tumor genomic testing is and why it matters. About 243 adults with advanced cancer will watch the video and answer questions before and after. The goal is to see if the video impro…

This study looks at whether doctors can consistently measure the chemotherapy drug paclitaxel in the blood of cancer patients. The goal is to see if adjusting the dose based on these levels could reduce nerve damage, a common and severe side effect. About 22 adults with various s…