STAGE III LUNG CANCER AJCC V8

This trial is testing a combination of three drugs (niraparib, temozolomide, and atezolizumab) to see if they work better together to control advanced cancers, especially a type called extensive-stage small cell lung cancer. The study first finds a safe dose, then compares the th…

This early-stage study aims to find the safest and most effective dose of a new drug, M6620, when given with the chemotherapy drug irinotecan. It is for adults with advanced solid tumors, like certain colorectal, pancreatic, or lung cancers, that have spread or cannot be removed …

This study is testing whether a lung cancer immunotherapy drug can be safely and effectively given at home by a visiting nurse, with most doctor visits done remotely via video call. It involves patients with non-small cell lung cancer who are eligible for the drug atezolizumab. T…

This study is testing a new, faster way to give radiation after surgery for non-small cell lung cancer. Instead of weeks of daily treatments, doctors give one powerful, highly focused dose to try to kill any leftover cancer cells while aiming to spare healthy lung tissue. The mai…

This study is testing whether combining two drugs, niraparib and dostarlimab, can help control recurrent small cell lung cancer and other aggressive neuroendocrine cancers. It is for adults whose cancer has returned after at least one prior treatment. The goal is to see if this c…

This early-stage study is testing whether adding an experimental drug called minnelide to an existing lung cancer medication (osimertinib) is safe and might help patients whose cancer has continued to grow. The trial is for adults with advanced non-small cell lung cancer that has…

This study is comparing two standard ways to treat small lung tumors: a minimally invasive procedure that uses microwave energy to heat and destroy the tumor, and a small surgery to cut it out. Researchers want to see which method is safer, more effective at keeping the cancer fr…

This study is testing a two-part treatment for patients with stage II or III non-small cell lung cancer who are not healthy enough for standard surgery or chemo-radiation. First, patients receive a shorter, more intense course of radiation. Then, they receive an immunotherapy dru…

This early-stage study is testing whether two immunotherapy drugs (ipilimumab and nivolumab) can be safely combined with radiation therapy for patients with stage II or III non-small cell lung cancer. The goal is to see if this combination helps the immune system attack the cance…

This early-stage trial is testing a new drug called BAY 1895344, given alongside standard chemotherapy drugs, in people with advanced solid tumors that have spread. The main goal is to find the safest and most effective dose of this combination. Researchers are especially interes…

This large study is testing if starting an immunotherapy drug called durvalumab earlier, alongside standard chemotherapy and radiation, works better for people with stage 3 non-small cell lung cancer that cannot be removed by surgery. The goal is to see if this approach helps pat…

This is a small, early-stage safety study testing a combination of two cancer drugs, nivolumab and cabozantinib, in people living with HIV who have advanced solid tumors. The main goal is to see if the two-drug combination is safe and tolerable for this specific patient group. Re…

This trial is testing whether combining an experimental cancer vaccine (CIMAvax) with approved immunotherapy drugs (nivolumab or pembrolizumab) is safe and more effective for treating advanced non-small cell lung cancer or squamous head and neck cancer. The study aims to find the…

This early-stage study is testing a new type of cell therapy for people with advanced non-small cell lung cancer that has spread and no longer responds to standard immunotherapy. Researchers are giving patients specially modified immune cells (called NK cells) taken from umbilica…

This trial is testing whether adding a new drug called LY3295668 to an existing lung cancer drug (osimertinib) can help control cancer that has stopped responding to standard treatment. It involves 32 adults with a specific type of advanced lung cancer (EGFR-mutant non-small cell…

This study is testing a combination of two drugs, trametinib and pembrolizumab, for people with advanced non-small cell lung cancer that has come back or spread after previous treatments. The goal is to see if the drugs work better together to control the cancer and to find the s…

This large study is testing whether adding an immunotherapy drug (atezolizumab) to standard chemotherapy and radiation treatment helps people with early-stage small cell lung cancer live longer. About 544 patients will be randomly assigned to receive either the standard treatment…

This study is testing a combination of three immunotherapy drugs—tocilizumab, ipilimumab, and nivolumab—in patients with advanced melanoma, non-small cell lung cancer, or bladder cancer. The main goal is to see if adding tocilizumab can help manage the serious side effects someti…

This early-phase study is testing a combination of two drugs, brigatinib and bevacizumab, for patients with a specific type of advanced lung cancer (ALK-positive) that has worsened despite prior targeted therapy. The main goals are to find the safest dose and understand the side …

This early-stage study is testing a new drug called NBTXR3, given as an injection directly into lung tumors, along with radiation therapy. The goal is to find the safest dose and see if the drug helps the radiation work better to kill cancer cells in people whose non-small cell l…

This study is testing whether a special program led by nurses can help people with advanced lung or gynecologic cancer cope with intense fears about their illness getting worse. Participants will have five short video sessions over six weeks to learn worry management skills, set …

This study is testing a simple, easy-to-understand conversation tool designed to help people with non-small cell lung cancer. The tool aims to improve how patients and doctors talk about treatment options, making the decision-making process clearer and less stressful. Researchers…

This study is testing a telehealth program designed to help people who have finished treatment for early-stage lung or colorectal cancer. It compares a special coaching program that teaches self-management skills to standard educational materials. The goal is to see if the coachi…

This study is testing an online support program designed to help women with lung cancer feel better emotionally and manage their symptoms. Participants are assigned to either a group learning mindfulness and coping skills or a group receiving educational information about lung ca…

This study is testing whether a medication called anamorelin can help improve appetite and prevent weight loss in people with advanced lung cancer who have poor appetite. Researchers will compare anamorelin against a placebo (inactive pill) in 25 patients over 9 weeks. The study …

This study aims to create a tool to predict which cancer patients are most likely to develop nerve damage (like tingling or numbness in hands and feet) from a common class of chemotherapy drugs called taxanes. Researchers will follow over 1,300 patients with breast, lung, or ovar…