PRIMARY ALDOSTERONISM

This study tests if a less invasive procedure called thermal ablation (using heat from a needle) works as well as surgery to cure primary aldosteronism, a condition where a small adrenal gland tumor causes high blood pressure. About 122 adults with a tumor in one adrenal gland wi…

This study tests an experimental drug called HRS-1780 in 60 adults with primary aldosteronism, a condition where the adrenal glands make too much of a hormone that raises blood pressure. The drug is compared to a placebo to see if it safely lowers blood pressure better than no tr…

This study tests a new, less invasive procedure called EUS-RFA (using ultrasound and heat) to treat small tumors on the left adrenal gland that cause a hormone disorder (primary aldosteronism) leading to high blood pressure. About 60 adults will receive the new procedure, and the…

This study looks at a better way to treat primary aldosteronism, a condition that causes high blood pressure. Doctors will use levels of the hormone renin to guide the dose of a specific blood pressure medicine (MRA). About 58 adults with this condition will be split into two gro…

This study looks at whether a procedure called superselective adrenal arterial embolization can improve blood vessel function in people with primary aldosteronism, a condition where the adrenal glands produce too much of the hormone aldosterone, leading to high blood pressure. Th…

This study tests a new steroid-based blood test to see if it can more accurately identify Primary Aldosteronism (a common, curable cause of high blood pressure) in people who continue taking their usual blood pressure medications. About 406 adults with high blood pressure will ha…

This study tests whether a special PET/CT scan (68Ga-Pentixafor) is as good as the standard adrenal vein sampling (AVS) for diagnosing a specific form of high blood pressure caused by a hormone imbalance (primary aldosteronism with extra cortisol). About 178 adults with adrenal n…

This study compares three ways of sampling blood from the adrenal veins to see which one best predicts treatment success for people with primary aldosteronism, a condition causing high blood pressure due to a hormone imbalance. About 456 adults aged 18-70 with this condition will…

This study looks at whether taking a single 1 mg dose of dexamethasone at bedtime can make screening for primary aldosteronism more accurate in people already taking blood pressure medications. Primary aldosteronism is a condition where the adrenal gland makes too much aldosteron…

This study follows 521 patients who had adrenal gland surgery for primary aldosteronism, some of whom also have extra cortisol production. Researchers want to see how often the remaining adrenal gland fails to make enough cortisol after surgery, how long it takes to recover, and …

This study follows 5,000 adults with primary aldosteronism, a hormone condition that causes high blood pressure and raises heart and kidney risks. Researchers will track patients for 5 years to see how different treatments (medication, surgery, or other procedures) affect their l…

This study follows 1000 adults with primary aldosteronism (a hormone condition that raises blood pressure) for up to 5 years to see how often thinking and memory problems develop. Participants take regular cognitive tests and medical check-ups. The goal is to understand how commo…

This study aims to find new ways to detect primary aldosteronism, a common cause of high blood pressure that is often missed. Researchers will analyze blood, urine, and adrenal tissue samples from 400 people, including patients and healthy volunteers. The goal is to identify biom…