PORTAL HYPERTENSION

This study tests whether adding a blood thinner (apixaban) to a standard heart drug (carvedilol) can prevent serious complications like bleeding, fluid buildup, and confusion in people with liver scarring (cirrhosis). About 220 adults with cirrhosis and high blood pressure in the…

This study tests two drugs, terlipressin and somatostatin, to see which one better lowers high blood pressure in the liver's main vein during a living-donor liver transplant. High pressure can cause dangerous bleeding, so finding the best drug may improve safety. About 50 adults …

This study compares early placement of a small tube (TIPS) that reroutes blood flow in the liver against standard treatments like water pills and fluid drainage. The goal is to see if the shunt helps people with liver cirrhosis and severe fluid buildup live longer without needing…

This study is checking how well a device called the Cera Vascular Plug works and if it is safe. The plug is used to block blood flow in certain blood vessels to treat conditions like aneurysms, abnormal connections between arteries and veins, and other problems. About 132 adults …

This study aims to improve how doctors see liver damage (cirrhosis), liver cancer, and high blood pressure in the liver using a special PET/MRI scan. About 45 adults with cirrhosis will get this scan to see if it gives clearer pictures than current methods. The goal is to make di…

This study tests whether a special ultrasound technique called SHAPE can detect high blood pressure in the liver (portal hypertension) without needing a risky catheter procedure. About 60 adults scheduled for the standard invasive test will also receive this noninvasive ultrasoun…

This study is testing whether a special MRI scan (3D-MRE) can accurately measure pressure in the liver's blood vessels, which is important for managing cirrhosis and advanced liver disease. Currently, doctors must insert a tube into a neck vein to measure this pressure, which is …

This study is creating a large collection of medical data and biological samples from 1000 people with portal hypertension, a condition that can cause dangerous bleeding in the esophagus or stomach. The goal is to use advanced technologies like genetics and imaging to better unde…

This study tests a new, safer method to measure pressure in the liver's blood vessels using an endoscope with ultrasound. It involves 30 adults with chronic hepatitis-related cirrhosis. The goal is to see if this technique can help predict serious complications like internal blee…

This study follows 10,000 people with advanced chronic liver disease to track their health over time. Researchers will collect medical data and samples like blood, urine, and tissue to better understand how cirrhosis progresses. The goal is to learn more about the disease, not to…

This study looks at why some people with liver cirrhosis develop blood clots in the portal vein (a major liver blood vessel). Researchers will compare blood samples taken from a neck vein and the portal vein during a routine procedure (TIPS) in 45 adults. The goal is to understan…

This study is testing a blood test called hepatomiR to see if it can predict when people with long-term liver disease will have serious complications like fluid buildup in the belly, bleeding in the stomach, or confusion. The goal is to better understand what causes these events …

This study looks at whether handgrip strength—a measure of muscle function—is linked to blood flow in the liver's main vein (portal vein) in people with liver cirrhosis. Researchers will measure pressure, speed, and direction of blood flow using different methods like ultrasound …

This study follows 2000 people who are getting a TIPS procedure—a small tube placed in the liver to relieve dangerously high blood pressure. Researchers will track survival, liver function, and complications for one year after the procedure. The goal is to learn more about outcom…

This study follows over 1,300 people with enlarged veins in the esophagus due to liver disease. Researchers compare those who get endoscopic treatment (using a scope) with those who receive other treatments like medication or surgery. The goal is to see which approach leads to fe…

This study compares a standard method (HVPG) with a newer, less invasive ultrasound-guided method (EUS-PPG) for measuring blood pressure in the liver. About 40 adults with liver disease who need this measurement will have both tests in one session. The goal is to see if the new m…

This study is a registry that will follow 500 adults with primary biliary cholangitis (PBC) in Austria to learn how the disease changes over time. Researchers will collect medical data and optional blood or liver samples to study biomarkers and complications. The goal is to bette…

This study looks at how well a procedure called TIPS works for people with a rare liver disease called Porto-Sinusoidal Vascular Disease (PSVD) that causes high blood pressure in the liver. Researchers will compare 360 patients who had TIPS for PSVD with similar patients who had …