PORTAL HYPERTENSION

This study tests a new way to use a stent (a small tube) in the liver to lower blood pressure and prevent dangerous bleeding in people with cirrhosis. The new method uses a smaller balloon to open the stent, which may reduce side effects. 240 adults who have recovered from a firs…

This study tests a new procedure using an endoscope with ultrasound to block part of the spleen's blood supply in people with liver cirrhosis. The goal is to raise low platelet counts and lower the risk of life-threatening bleeding from swollen veins in the stomach or esophagus. …

This study tests a new combination of four treatments for people with liver cancer that cannot be removed by surgery and who also have high blood pressure in the liver (portal hypertension). The goal is to see if adding a blood-pressure drug (carvedilol) to standard cancer therap…

This study looks at better ways to treat bleeding from enlarged veins in the stomach and esophagus caused by liver disease. Over 1,000 adults will be assigned to either endoscopic therapy or a procedure called TIPS to see which works best to prevent future bleeding. The goal is t…

This study looks at whether non-invasive tests like blood counts and spleen size can accurately predict the presence and severity of enlarged veins (varices) in the esophagus of children with portal hypertension. The goal is to identify those at high risk of bleeding without need…

This study looks at whether a special 4D MRI scan can accurately measure blood flow and pressure in the liver without needing an invasive needle procedure. It will enroll 60 adults with cirrhosis, some with early-stage disease and others needing a shunt (TIPS) for complications. …

This study looks at whether a combination of ultrasound and spleen stiffness measurements can accurately detect dangerous high blood pressure in the liver (portal hypertension) without needing an invasive procedure. Researchers will enroll 107 adults with liver cirrhosis and comp…

This study tests a fiber-optic navigation system during a procedure called TIPS, which treats complications of liver cirrhosis like fluid buildup and bleeding. About 30 patients will take part to see if the new technology reduces the number of needle sticks, radiation exposure, a…

This study looks at whether a simple, non-invasive ultrasound can predict the risk of dangerous bleeding from enlarged veins in the esophagus (varices) in people with liver cirrhosis. Researchers will measure spleen size and a key blood vessel diameter on ultrasound and compare t…

This study looks at 2,500 adults with liver scarring (cirrhosis) or high blood pressure in the liver (portal hypertension) who are scheduled for elective medical procedures. The goal is to find out how often bleeding happens and what factors predict it, since standard blood tests…

This study follows 30 adults with liver cirrhosis and a history of bleeding from high blood pressure in the liver. They will have laparoscopic spleen removal and a blood vessel disconnection. Researchers will measure kidney function before and for two years after surgery to see i…

This study follows 30 adults with liver cirrhosis and a history of bleeding from high blood pressure in the liver. They will have a surgery called laparoscopic splenectomy and azygoportal disconnection. The goal is to see how their blood fat levels (like cholesterol) change over …