MESOTHELIOMA

This early-stage study is testing a new type of personalized cell therapy for people with advanced solid tumors, including mesothelioma, that have come back or spread after standard treatments. Doctors collect a patient's own immune cells, genetically modify them in a lab to bett…

This early-stage study is testing a new drug called VT3989, both alone and in combination with other cancer therapies. It aims to find a safe dose and see if it can help control advanced solid tumors and mesothelioma that have stopped responding to standard treatments. The trial …

This study is testing whether giving magnesium through an IV during surgery can help protect the kidneys of people with mesothelioma. Patients receiving a specific heated chemotherapy treatment during surgery are at risk for sudden kidney injury. Researchers will compare magnesiu…

This study is testing a new radiation therapy approach that uses MRI scans during treatment to adjust radiation beams in real time. Researchers want to see if this method can better target tumors while sparing healthy tissue in patients with various cancers including pancreatic, …

This is the first study in people to test a new drug called NXP900 for advanced solid tumors. The main goals are to find a safe dose and see how the body processes the drug. The study will also look for early signs that the drug can shrink tumors, especially in cancers with speci…

This early-stage study is testing a new oral drug called VMD-928, both by itself and combined with an existing immunotherapy (pembrolizumab). It is for adults with advanced solid tumors or lymphoma that have progressed despite available treatments. The main goals are to find safe…

This early-stage study is testing a new drug, IDE892, both alone and in combination with another drug called IDE397. It is for adults with advanced solid tumors that have a specific genetic change called MTAP deletion and have stopped responding to standard treatments. The main g…

This is the first study in people of an experimental pill called MRTX1719. It is for adults with advanced solid tumors that have a specific missing gene called MTAP, which is found in some lung cancers, mesothelioma, and other cancers. The main goals are to find a safe dose, see …

This study is testing two different drug combinations given before surgery for pleural mesothelioma, a cancer often linked to asbestos exposure. The goal is to see if these treatments can better control the cancer and keep it from coming back after surgery. Researchers will compa…

This study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have come back or spread. The therapy, called Tmod CAR T, is designed to recognize and kill cancer cells while using a built-in safety switch to protect the patient's healthy …

This study is testing a new drug called Rina-S in people whose solid tumor cancers have spread or cannot be removed by surgery. The main goals are to find a safe dose and see if the drug can shrink tumors. It is for people with several types of advanced cancer, including ovarian,…

This study is testing a new type of targeted radiation therapy for people with advanced solid tumors that have stopped responding to standard treatments. The therapy uses a radioactive drug designed to seek out and deliver a powerful dose of radiation directly to cancer cells. Th…

This study is testing a new imaging substance called [18F]FAPI-74 to see if it can detect certain cancers better than current standard scans. It will involve 320 adults with one of 10 specific cancer types who are scheduled for treatment. Participants will receive both the new tr…

This study is testing a new portable X-ray machine that takes moving pictures of the lungs. It aims to see if this technology is safe and practical to use at the bedside in the Intensive Care Unit (ICU) and if it gives doctors more useful information than standard chest X-rays. R…

This study is testing whether a surgery to remove part of the lung lining can help reduce symptoms and improve quality of life for people with advanced pleural mesothelioma that cannot be fully removed. Researchers will follow 30 participants for about 2 years after surgery to tr…

This study aims to better understand the biological makeup of pleural and peritoneal mesothelioma tumors to identify potential new treatment approaches. Researchers will analyze tumor samples from 220 patients to study immune system interactions and genetic patterns. The findings…

This study aims to learn if advanced imaging scans, blood tests, and minor surgical procedures can help detect mesothelioma and other cancers earlier in people who carry an inherited BAP1 gene mutation. Researchers will follow 800 adults age 30+ with this mutation, performing ann…

This study aims to collect detailed information on 12,000 patients with lung and other chest cancers over many years. By tracking their treatments, health, and quality of life, researchers hope to understand why outcomes vary so much between patients. The goal is to use this real…

This study aims to understand how cancer develops in people who are born with specific gene mutations, like the BAP1 gene, which is linked to mesothelioma and other cancers. Researchers will follow 1,000 participants, including people with mesothelioma and their family members wh…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study aims to better understand how inherited changes in the BAP1 gene increase the risk for several types of cancer, including eye and skin melanoma, kidney cancer, and mesothelioma. Researchers will enroll 500 participants who have a personal or strong family history of th…

This study is testing a new method to better predict how mesothelioma will progress and respond to treatment. Researchers will analyze tissue samples from 240 patients collected during routine diagnostic biopsies. The goal is to develop a more accurate way to determine cancer sta…

This study is testing a new laboratory method to see if it can predict which cancer treatments will work best for a patient. Researchers will take a sample of a patient's tumor cells from a fluid or tissue biopsy and test how the cells react to different drugs in the lab. The goa…

This study aims to collect blood, urine, and tumor samples from up to 1,000 patients with mesothelioma and other related cancers. The purpose is to build a tissue bank for future research to better understand these diseases. Participants will be followed over time to track their …

This study aims to collect tumor tissue and blood cells from people with advanced solid tumors to prepare for future CAR T-cell therapy. Researchers will analyze the cancer tissue to understand how tumors hide from the immune system and collect participants' own immune cells thro…

This study aims to collect cancer tissue samples shortly after death to help researchers understand how cancers spread and become resistant to treatments. Adults with advanced lung, ovarian, bladder, or certain other cancers who are receiving end-of-life hospice care can particip…