LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Clinical trials for LOCALLY ADVANCED RECTAL ADENOCARCINOMA explained in plain language.
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Immunotherapy duo takes on tough rectal cancer
Disease control Recruiting nowThis study tests whether two immunotherapy drugs, botensilimab and balstilimab, can shrink or eliminate rectal tumors in people with a specific type of rectal cancer (MMRp/MSS) that usually doesn't respond to immunotherapy alone. About 40 adults with stage II or III rectal cancer…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Could citrus flavonoids boost chemo for rectal cancer? new trial launches
Disease control Recruiting nowThis study tests whether adding a citrus flavonoid tablet (Aimailang) to standard chemotherapy (mFOLFOX) before surgery can shrink tumors more effectively in people with locally advanced rectal cancer that has a specific marker (YWHAB). About 236 participants will be randomly ass…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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New combo therapy aims to boost rectal cancer survival
Disease control Recruiting nowThis phase 3 trial tests whether adding an immunotherapy drug (HLX10) to standard chemotherapy and radiation before surgery improves outcomes for people with locally advanced rectal cancer. It compares short-course versus long-course radiation, both followed by immunotherapy and …
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE3 • Sponsor: Tao Zhang • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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New drug cocktail aims to shrink rectal tumors before surgery
Disease control Recruiting nowThis phase 2 trial tests whether adding two targeted drugs (tucatinib and trastuzumab) to standard chemotherapy can shrink HER2-positive rectal tumors before surgery. About 37 adults with locally advanced rectal cancer will receive the drug combo for 6 weeks, then continue it wit…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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New radiation combo may let some rectal cancer patients skip surgery
Disease control Recruiting nowThis early-phase trial is testing a new way of giving radiation therapy (ultra-fractionated, short course) along with standard chemotherapy for people with locally advanced rectal cancer. The goal is to see if this combination can shrink the tumor enough to avoid surgery. The stu…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE1 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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New combo therapy aims to save rectums from surgery in rectal cancer trial
Disease control Recruiting nowThis phase 2 trial is testing a new approach for people with a certain type of locally advanced rectal cancer. The treatment combines short-course radiation (sparing lymph nodes), two chemotherapy drugs (capecitabine and oxaliplatin), and an immunotherapy drug (sintilimab). The g…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Jinhua Central Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Could a simple supplement boost rectal cancer treatment?
Disease control Recruiting nowThis phase 2 trial is testing whether adding a dietary supplement called β-hydroxybutyrate to a standard treatment plan (short-course radiotherapy, immunotherapy, and chemotherapy) can improve outcomes for people with locally advanced rectal cancer. The study will enroll 25 adult…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Tao Zhang • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New combo aims to beat rectal cancer without surgery
Disease control Recruiting nowThis study tests whether adding the immunotherapy drug camrelizumab to standard chemoradiotherapy can make rectal tumors disappear completely in people with a common type of locally advanced rectal cancer. About 44 adults aged 18-75 with tumors within 10 cm of the anus will recei…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Chinese PLA General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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MRI-Guided therapy could spare rectal cancer patients from unnecessary surgery
Disease control Recruiting nowThis study is for people with locally advanced rectal cancer. It tests whether using MRI scans early after chemotherapy can help doctors choose the best next step: surgery or more chemo with radiation. The goal is to improve cancer control and reduce side effects. About 1,075 par…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2, PHASE3 • Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Heat waves against cancer: new trial tests hyperthermia for rectal tumors
Disease control Recruiting nowThis phase 3 trial tests whether adding modulated electro-hyperthermia (mEHT) to standard treatment helps shrink locally advanced rectal cancer. About 126 adults will receive either standard therapy alone or with mEHT twice a week for six weeks. The goal is to see if the heat-bas…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE3 • Sponsor: Shih-Kai Hung • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Could a simple supplement make rectal cancer treatment more effective?
Disease control Recruiting nowThis study is testing whether adding leucine, a common amino acid found in food, to standard chemoradiotherapy can help shrink tumors more effectively in people with locally advanced rectal cancer. The researchers believe leucine may interfere with cancer cells' ability to repair…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: NA • Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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New combo therapy aims to save rectums in advanced cancer
Disease control Recruiting nowThis phase 2 trial is testing a new approach for patients with a specific type of locally advanced rectal cancer (MSS-type). Participants will receive a short course of radiation, followed by chemotherapy combined with two additional drugs: serplulimab (an immunotherapy) and beva…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: First Affiliated Hospital of Wenzhou Medical University • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Immunotherapy boosts standard treatment for rectal cancer in new trial
Disease control Recruiting nowThis clinical trial is testing whether adding the immunotherapy drug tislelizumab to standard chemoradiation helps people with locally advanced rectal cancer. The study involves 375 participants who will receive either the combination or standard treatment alone. The main goal is…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2, PHASE3 • Sponsor: Beijing Friendship Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Triple therapy aims to shrink rectal tumors without surgery
Disease control Recruiting nowThis phase II trial tests whether adding immunotherapy and a COX-2 inhibitor to standard chemoradiotherapy can improve complete remission rates in people with locally advanced rectal cancer that is microsatellite stable (MSS). About 138 participants will receive either long-cours…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Fudan University • Aim: Disease control
Last updated Jun 26, 2026 13:53 UTC
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Immunotherapy combo shows promise against tough rectal cancers
Disease control Recruiting nowThis study tests whether adding the immunotherapy drug pucotenlimab to standard chemoradiation can improve outcomes for people with locally advanced rectal cancer. About 68 participants will receive the combination, and doctors will check if the tumor disappears completely. If it…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Disease control
Last updated Jun 26, 2026 13:43 UTC
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New scan could predict rectal cancer treatment success early
Knowledge-focused Recruiting nowThis study is testing whether special PET-MRI scans can predict how well rectal cancer responds to chemotherapy and radiation before surgery. Researchers will scan 50 patients multiple times during treatment to see if early changes in the tumor can forecast the final outcome. The…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Sponsor: Centre Paul Strauss • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New MRI technique may tell doctors if cancer is gone before surgery
Knowledge-focused Recruiting nowThis study looks at whether a special type of MRI, called amide proton transfer-weighted imaging, can accurately predict if rectal cancer has completely disappeared after chemotherapy and radiation. Researchers will compare the MRI results with the actual tissue removed during su…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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AI model may predict who can skip surgery for rectal cancer
Knowledge-focused Recruiting nowThis observational study is developing a model that combines MRI scans, blood tests, and tissue samples to predict whether rectal cancer patients achieve a complete response after neoadjuvant therapy. Researchers will enroll 106 patients with locally advanced rectal cancer and co…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC