LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Clinical trials for LOCALLY ADVANCED RECTAL ADENOCARCINOMA explained in plain language.
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New combo therapy aims to shrink rectal tumors and save organs
Disease control Not yet recruitingThis study tests whether adding two immunotherapy drugs to radiation therapy can better shrink advanced rectal cancer than standard chemoradiation. About 342 adults with a specific type of rectal cancer will be randomly assigned to one of three treatment groups. The goal is to se…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2, PHASE3 • Sponsor: Beijing Friendship Hospital • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Oxygen-Boosting injection may help rectal cancer patients avoid surgery
Disease control Not yet recruitingThis study tests whether injecting a special solution (KRC-01) into rectal tumors before radiation can make the radiation work better. The solution increases oxygen inside the tumor, which helps radiation kill cancer cells. About 24 adults with advanced rectal cancer that hasn't …
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Gustave Roussy, Cancer Campus, Grand Paris • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Triple threat: immunotherapy, chemo, and radiation take on rectal cancer
Disease control Not yet recruitingThis phase 2 trial is testing whether adding an immunotherapy drug (adebrelimab) to a chemotherapy combo (NALIRIFOX) and radiation can improve outcomes for people with a certain type of locally advanced rectal cancer (pMMR/MSS). About 84 participants will be randomly assigned to …
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New Pre-Surgery combo aims to shrink rectal tumors and save the rectum
Disease control Not yet recruitingThis study tests a new treatment plan for adults with locally advanced rectal cancer that hasn't spread. Participants get a week of radiation, then 8 cycles of three drugs (chemotherapy and immunotherapy) before surgery. The goal is to shrink the tumor enough to cure the cancer o…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Guangdong Provincial People's Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Immunotherapy plus chemo shows promise in rectal cancer trial
Disease control Not yet recruitingThis phase 2 trial tests whether adding an immunotherapy drug (iparomlimab and tuvonralimab) to standard chemoradiotherapy before surgery can improve outcomes for people with locally advanced rectal cancer. About 108 participants will be randomly assigned to receive either the st…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Zhongnan Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Promising drug duo targets Hard-to-Treat HER2 cancers
Disease control Not yet recruitingThis study tests two drugs, zanidatamab and tislelizumab, combined with standard chemo or radiation for people with HER2-positive stomach or colorectal cancers. About 70 adults aged 18-75 will receive the treatment to see if it shrinks tumors and controls the disease. The goal is…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Tao Zhang • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Immunotherapy combo aims to wipe out High-Risk rectal cancer before surgery
Disease control Not yet recruitingThis study is testing whether adding an immunotherapy drug (PD-1 inhibitor) to standard chemoradiation can better shrink or eliminate tumors in people with locally advanced rectal cancer that has a high chance of coming back. About 30 participants will receive the combination tre…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: The First Affiliated Hospital of University of Science and Technology of China • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Boosting radiation may help more rectal cancer patients reach remission
Disease control Not yet recruitingThis study tests whether a higher dose of radiation (58.75 Gy) given before surgery can help more people with locally advanced rectal cancer achieve a complete response (no cancer left) compared to the standard dose (50 Gy). About 156 adults aged 18-79 will receive radiation plus…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Peking Union Medical College Hospital • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Pumping iron against cancer: exercise may ease treatment side effects
Symptom relief Not yet recruitingThis study tests whether a supervised strength-training program is safe and practical for people with locally advanced rectal cancer who are receiving chemotherapy and radiation before surgery. Fifteen participants will do personalized resistance exercises twice a week for about …
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: NA • Sponsor: Fundacion Arturo Lopez Perez • Aim: Symptom relief
Last updated Jun 27, 2026 09:11 UTC
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Blood test may decide who needs surgery for rectal cancer
Knowledge-focused Not yet recruitingThis phase 2 trial tests whether a highly sensitive blood test (ctDNA) can help manage treatment for 200 people with early-stage rectal cancer. After standard chemotherapy and radiation, some patients will have their treatment guided by the blood test results instead of immediate…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: University of California, Davis • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC