LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Clinical trials for LOCALLY ADVANCED RECTAL ADENOCARCINOMA explained in plain language.
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New Immune-Boosting drug tested to shrink rectal tumors before surgery
Disease control OngoingThis study is testing if adding an experimental immunotherapy drug (APX005M) to standard radiation and chemotherapy before surgery helps shrink rectal tumors more effectively. It will involve 58 adults with locally advanced rectal cancer who have not had prior treatment. The main…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Immunotherapy combo aims to shrink rectal tumors before surgery
Disease control OngoingThis study is testing a new treatment approach for people with locally advanced rectal cancer that has a specific genetic marker (MSI-H/dMMR). The goal is to see if giving two immunotherapy drugs (nivolumab and ipilimumab) along with a short, intense course of radiation before su…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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Blood holds clues to rectal Cancer's future
Knowledge-focused OngoingThis study aims to learn if tiny pieces of cancer floating in the blood can help doctors understand how rectal cancer responds to treatment. Researchers are collecting blood samples from 341 patients with rectal cancer and some healthy volunteers to track these 'circulating tumor…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:19 UTC