LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Clinical trials for LOCALLY ADVANCED RECTAL ADENOCARCINOMA explained in plain language.
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Immunotherapy plus radiation may eliminate rectal cancer before surgery
Disease control OngoingThis study tests whether giving two immunotherapy drugs (nivolumab and ipilimumab) along with a short course of radiation can completely eliminate advanced rectal cancer before surgery. About 31 adults with a specific genetic type (MSI-H/dMMR) of stage II or III rectal cancer wil…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Short radiation plus chemo before surgery may boost rectal cancer survival
Disease control OngoingThis phase 3 trial compares two treatment approaches for high-risk rectal cancer. The experimental group gets a short course of radiation (5 days) followed by several months of chemotherapy before surgery. The standard group receives longer chemoradiotherapy followed by surgery a…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE3 • Sponsor: University Medical Center Groningen • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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Immunotherapy boosts standard treatment for rectal cancer?
Disease control OngoingThis phase 2 trial tests whether adding the immunotherapy drug nivolumab (Opdivo) to standard chemoradiation and chemotherapy can improve outcomes for people with locally advanced rectal cancer. About 29 participants who have not had prior treatment will receive chemoradiation, t…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Baruch Brenner • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Less cutting, same cure? new trial tests smaller surgery for rectal cancer
Disease control OngoingThis study tests whether surgeons can safely remove less tissue during surgery for upper rectal cancer after patients have received pre-surgery therapy. About 874 adults with locally advanced rectal cancer will be randomly assigned to either standard or reduced surgical margins. …
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: NA • Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Immunotherapy shows promise for untreated rectal cancer in chinese patients
Disease control OngoingThis study tests a drug called dostarlimab in 23 Chinese patients with a specific type of advanced rectal cancer (dMMR/MSI-H) that has not been treated before. The goal is to see if the drug can make the cancer disappear completely and stay gone for at least 12 months. Patients r…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: GlaxoSmithKline • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Three-Drug chemo may let some rectal cancer patients skip surgery
Disease control OngoingThis phase II trial compares a three-drug chemotherapy combination (FOLFIRINOX) against standard two-drug combos (FOLFOX or CAPOX) in 783 patients with locally advanced rectal cancer. The goal is to see if the stronger regimen leads to a complete disappearance of the tumor, poten…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Jun 26, 2026 15:05 UTC
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Blood tests could reveal secrets of rectal cancer
Knowledge-focused OngoingThis study looks at tiny pieces of cancer cells or DNA floating in the blood of people with rectal cancer. Researchers want to see if these markers can help predict how the tumor responds to standard treatment. About 341 participants, including healthy volunteers, will provide bl…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Study aims to find safer radiation approach for rectal cancer surgery
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at 266 adults with advanced rectal cancer who had radiation therapy followed by surgery. It compares standard chemoradiotherapy or short-course radiotherapy with a newer approach called total neoadjuvant treatment (TNT). The goal is to see which method leads to f…
Matched conditions: LOCALLY ADVANCED RECTAL ADENOCARCINOMA
Sponsor: Istituto Clinico Humanitas • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC