INFECTIONS

This study tests a new vaccine called GNG-DE to see how well it protects against meningococcal infections (a cause of meningitis). About 240 people aged 3 to 55 will receive either the new vaccine or a reference vaccine. Researchers will measure immune responses and check for sid…

This study tests a wireless, bioelectric bandage called PowerHeal™ on infected wounds. Researchers want to see if it clears infection and helps wounds close better than standard care. About 150 adults with infected traumatic wounds will take part. The bandage is changed regularly…

This study tests whether giving a single 2-gram dose of azithromycin to pregnant women before starting labor induction can lower the chance of infections like chorioamnionitis in mothers and infections in newborns. About 400 women in their third trimester with a singleton pregnan…

This study tests whether giving L-Citrulline syrup for 28 days can reduce serious complications (like death, organ failure, or readmission) in children aged 1 month to 5 years who are hospitalized with fever and identified as high-risk by a rapid biomarker test. About 888 childre…

This study tests if taking antibiotic pills for 6 weeks works as well as getting antibiotics through an IV for treating infected broken bones that haven't healed properly. About 250 adults with this condition will be randomly assigned to either oral or IV antibiotics, along with …

This study compares a new approach to managing infections in nursing home residents with dementia against usual care. The goal is to see if the new method reduces antibiotic use and avoids stressful procedures like hospital transfers. About 750 residents aged 60 and older with de…

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

This study tests whether checking vancomycin levels after the first dose and adjusting quickly helps infants with sepsis reach the right drug concentration sooner. About 40 infants under 90 days old will receive model-based dosing and early monitoring. The goal is to improve infe…

This study tests an experimental drug called recombinant human plasma gelsolin (rhu-pGSN) added to standard care for people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. About 600 hospitalized adults will receive eithe…

This study collects blood samples from 20,000 adults with infections, heart disease, blood clots, or kidney disease. The goal is to develop and fine-tune new diagnostic tests that can give fast results at the doctor's office. Participants provide blood samples for testing with bo…

This study is looking for new ways to quickly diagnose sepsis, a life-threatening reaction to infection, in the emergency room. Researchers will study the immune responses of 3300 adults with suspected infections to find patterns that signal sepsis. The goal is to help doctors id…

This study looks at a different way of stitching after breast removal surgery to prevent seroma, a common fluid buildup under the skin. Normally, two drains are placed to remove fluid. Here, doctors will use quilting stitches to attach the skin to the chest muscle, and compare us…

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1,200 adults for one year, measuring kidney function and looking at conditions like diabetes, high blood pressure, a…

This study follows 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will collect data on pain, daily activities, and strength using standard shoulder scores. The goal is to better understand…

This study measures how much of the antibiotic meropenem-pralubactam gets into the lungs of 16 healthy adults in China. Participants receive four doses of the drug, and researchers check levels in blood and lung fluids. The goal is to understand drug distribution, not to treat an…

This study tests whether an augmented reality (AR) system can safely help doctors guide needles during MRI scans. About 25 people aged 3 to 21 who need a needle procedure will take part. The main goal is to see if the AR system works well and does not cause extra side effects.

This study tests whether a special parenting program (Attachment Biobehavioral Catch-Up) can help low-income Latino children have fewer illnesses, better sleep, and healthier weight. About 260 mothers and their 9-month-old babies will take part. The program focuses on strengtheni…

This study is creating a personalized immune score to predict severe infections in immunocompromised patients, such as those who have received stem cell or organ transplants. Researchers will measure immune cells and virus-specific responses before or one month after transplant. …

This study looks at a type of bacteria called Bacillus cereus that can cause severe blood infections in premature babies, with a death rate up to 30%. Researchers will use advanced genetic testing to analyze bacteria from 40 infected infants and combine that with medical records …

This project works to improve how doctors diagnose and treat infections in people with heart devices like pacemakers. It brings together teams of specialists to follow best-practice guidelines. The goal is to identify infections faster and start the right treatment sooner. About …

This study looks at whether people with cystic fibrosis can collect sputum (mucus) samples at home and mail them in to detect lung infections as accurately as samples taken in a clinic. With newer treatments reducing mucus production, diagnosing infections has become harder. The …

This study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes severe skin and lung infections. Researchers will follow 600 patients and their relatives over time to understand the genetic causes and health problems linked to the condition. No new trea…

This study looks at how common certain infections are among 250 asylum seekers living in reception centers in Italy. Participants must be adults who arrived in Italy between 2 and 36 months ago. The goal is to better understand infection rates to improve health screening and care…

This study is for women who have had first-stage breast reconstruction with tissue expanders and surgical drains. It compares showering 48 hours after surgery versus not showering to see if showering increases the chance of infection. Researchers will also check how showering aff…

This study aims to reduce maternal sepsis, a severe infection that is a top cause of death in new mothers in the U.S. Researchers will create and test a safety bundle (a set of best practices) across four hospitals. They will track how many birthing people develop sepsis before a…

This study tracks 150 adults getting a HeartMate 3 heart pump to see if the pump's data (like alarms and power changes) can predict problems such as bleeding, infection, or frailty. Researchers will also check if this data relates to quality of life. The goal is to find patterns …

This study looks at infections that happen after surgery to remove esophageal cancer. Researchers will review medical records of 350 adults who had this surgery in France between 2017 and 2024. The goal is to find out how common these infections are, what causes them, and how the…