HYPERTENSION (HTN)

This study looks at the long-term safety and effectiveness of the drug QCZ484 in people with high blood pressure. It is for patients who already completed a previous study with the same drug. Researchers will monitor side effects and track blood pressure changes over time.

This study tests whether adding a 10-week health coaching program from a community health worker to remote blood pressure monitoring helps women who had high blood pressure during pregnancy. 240 women will be followed for 6 months after delivery. The goal is to see if the combine…

This study compares a wearable blood pressure monitor (Aktiia G1) to a traditional arm cuff in adults with uncontrolled high blood pressure. Over 6 months, researchers will see which method leads to better blood pressure control. Participants must have a smartphone and attend two…

This Phase 3 trial compares two treatments for people with high blood pressure and chronic kidney disease: finerenone versus a fixed-dose combination of torsemide and spironolactone. The study will enroll 30 adults to see which approach better lowers blood pressure, reduces prote…

This study tests whether trained female community health volunteers can help people in Nepal better manage high blood pressure and diabetes. The health workers will lead group meetings, provide health education, and coordinate care with local clinics. About 398 adults with both c…

This study tests whether doing wall squats at home, along with lifestyle advice, is a practical and acceptable way for people with high blood pressure to manage their condition. Seventy adults with hypertension will do supervised wall squat exercises three times a week for 12 wee…

This study tests whether combining transcutaneous electrical nerve stimulation (TENS) with isometric exercise can improve blood pressure in people with resistant hypertension. Resistant hypertension means blood pressure stays high despite taking three or more medications. The tri…

This study looks at whether using a CPAP machine, sometimes with a mild sleep aid, can help lower blood pressure in people with both sleep apnea and high blood pressure. About 200 adults aged 18-70 will use CPAP every night for 3 months. Those with insomnia can also take trazodon…

This Cleveland Clinic study tests a team-based approach where patients with uncontrolled high blood pressure measure their BP at home and adjust medications with help from pharmacists and providers via phone or video visits. About 1520 adults aged 18-85 with BP over 150/95 will t…

This study compares two types of exercise—short, intense bursts (SIT) versus steady moderate activity (MICT)—to see which better lowers blood pressure in adults aged 30-59 with hypertension. Participants will do supervised workouts three times a week for 12 weeks. The goal is to …

This study looks at whether adding alternate nostril breathing to aerobic interval training (stationary cycling) can lower blood pressure and heart rate more than exercise alone. Researchers will enroll 36 adults aged 25-50 with stage 1 or 2 hypertension. Participants will cycle …

This study is testing a chest-patch that uses light to measure blood pressure without a traditional arm cuff. Researchers will compare its readings over 24 hours to the standard cuff-based method in 600 adults with or without high blood pressure. The goal is to see if the patch i…

This study tests whether a simple handgrip exercise can safely lower blood pressure and improve thinking skills in pregnant women with and without chronic hypertension. Thirty pregnant women will either perform short handgrip squeezes or rest quietly, and researchers will measure…

This study tests whether doing very short wall-squats (just a few minutes) at four different times each day can lower blood pressure in people with hypertension or pre-hypertension. Researchers will compare this approach to doing all the squats at once. The goal is to find a simp…

This study is testing whether a beetroot extract supplement can lower blood pressure and improve muscle oxygen levels in older women (ages 60-70) with high blood pressure during a single aerobic exercise session. Twenty participants will take either the beetroot supplement or a p…

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This study is looking at 150 Division I athletes from historically Black colleges and universities (HBCUs) to see how not getting enough calories—called low energy availability—might harm their hearts. Researchers will measure things like artery stiffness, blood sugar, and choles…

This study is checking whether people newly diagnosed with high blood pressure who also have high homocysteine levels are more likely to have early signs of heart stiffness. Researchers will measure homocysteine in blood and use ultrasound to look at heart function in 500 adults.…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study is testing whether two dietary supplements, Goodphyte IB Defense and Goodphyte Immunity, are acceptable and easy for adults with chronic diseases like IBD, hypertension, anemia, or multiple sclerosis to take. Researchers will also check if the supplements improve how w…

This registry will follow 100 adults in France who undergo renal denervation (RDN) for high blood pressure. The procedure uses radiofrequency or ultrasound to calm overactive kidney nerves. Researchers will measure blood pressure changes at home and in the clinic over one year to…