HYPERTENSION (HTN)

This study tests whether combining two medications, empagliflozin and finerenone, can lower blood pressure in adults with obesity and stage 1 hypertension. Participants take the drugs or a placebo daily for 12 weeks. The trial also measures effects on kidney function, inflammatio…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This study tests whether a mobile health program—combining home blood pressure monitoring with virtual coaching—can help midlife women control high blood pressure after having had a hypertensive disorder of pregnancy (like preeclampsia). About 50 women who had such a pregnancy 10…

This study gives 400 adults with diabetes or high blood pressure free home-delivered produce boxes and vouchers for 6 months, plus nutrition education and self-management classes. The goal is to see if this helps them eat more fruits and vegetables, feel less food insecure, and i…

This study looks at whether giving people with high blood pressure and food insecurity $100 a month for fruits and vegetables can improve their health. It focuses on Native Hawaiian and Pacific Islander adults in Hawaii. Some participants will also get one-on-one help from a comm…

This pilot study tests a special pacemaker-like device called Moderato Plus in 20 people with high blood pressure and a type of heart failure where the heart pumps normally but is too stiff (HFpEF). The device delivers Cardiac Neuromodulation Therapy to help control blood pressur…

This study tests whether a clinical decision support tool, embedded in electronic medical records, helps doctors prescribe more effective blood pressure medications. About 168 adults with uncontrolled hypertension will be enrolled. The main goal is to see if the tool leads to low…

This study looks at whether a program called HEARTS can help people who have both high blood pressure and diabetes get better care. About 1,440 adults in Guatemala will take part, and clinics will either use the HEARTS program or continue their usual care. The program includes tr…

This study tests a 3-week online lifestyle program for adults aged 60-75 with high blood pressure. The program focuses on healthy eating, exercise, stress management, sleep, social support, and avoiding risky substances. Researchers will measure changes in blood pressure, quality…

This study tests a program for new mothers who had high blood pressure during pregnancy. Participants wear a FitBit and receive weekly messages with personalized activity goals. The goal is to see if this approach increases daily steps and improves blood pressure, and whether mom…

This study tests whether taking a vitamin B3-like supplement (nicotinamide riboside) combined with brisk walking twice a week can lower blood pressure in post-menopausal women with early-stage hypertension. 112 women will be randomly assigned to one of four groups: supplement plu…

This study tests a 6-week program designed for people with high blood pressure who have low health literacy. Participants attend group sessions and get phone coaching to learn how to manage their condition. The goal is to see if this approach can lower blood pressure better than …

This study expands a successful blood pressure program to 50 primary health centers across five Nigerian states. Over 10,000 adults with high blood pressure will receive simplified care from trained non-physician health workers, following the WHO HEARTS package. The goal is to im…

This study tests whether a 12-week program of home-delivered DASH-diet groceries and cooking classes can help adults with high blood pressure and obesity lower their blood pressure and lose weight. 150 participants will be randomly assigned to either the food program or usual car…

This small pilot study will test a brief online mindfulness program (B-MORE) in 20 adults with high blood pressure and chronic stress. Participants attend two 60-minute virtual group sessions to learn stress management techniques. The study aims to see if the program is feasible …

This study tests whether tension and trauma releasing exercises (TRE) can improve quality of life and sleep in 40 adults aged 50-65 with stage 1 hypertension. Participants will do supervised TRE sessions for 8 weeks. Researchers will measure changes in sleep quality and well-bein…

This study will follow 100 adults whose high blood pressure remains high despite taking at least two medications. Over three months, researchers will track changes in blood pressure and other health markers to find patterns that could help identify which patients might respond be…

This study will test two new non-invasive devices (HEMI and SPG-NINOX) that measure small blood vessel function in 165 adults. Participants include healthy volunteers and people with high blood pressure, type 2 diabetes, or chronic kidney disease. The goal is to see if these devi…

This study follows 2,500 adults in Mexico aged 18 to 65 who do not yet have type 2 diabetes or high blood pressure. Over five years, researchers will track their health through yearly check-ups, blood tests, and lifestyle questionnaires. The goal is to identify what factors incre…

This study looks at how genes influence heart hormones called natriuretic peptides, which help control blood pressure and metabolism. Researchers will give 200 adults with mild high blood pressure low-salt and high-salt diets, plus a saline infusion, to see how their blood pressu…