HIV (HUMAN IMMUNODEFICIENCY VIRUS)

This trial aims to find a functional cure for HIV by using a combination of three existing drugs to 'shock' the hidden, dormant virus out of hiding so the immune system can 'kill' it. It will involve 30 adults with well-controlled HIV. The study first tests single doses for safet…

This study is testing a new computer software tool designed to help doctors choose the best combination of HIV medications for their patients. Doctors will use the tool to review patient cases and see if it helps them make treatment decisions that better follow medical guidelines…

This study is for adults with HIV who have stopped their medication for at least 12 weeks and want to restart treatment. It tests a faster process where participants begin taking a standard, once-daily HIV pill (B/F/TAF) on the very same day they return to the clinic. Researchers…

This study is testing an experimental vaccine called PDS0101 in adults living with HIV who also have an HPV 16 infection. The goal is to see if the vaccine is safe and can help the immune system fight the HPV virus, which can cause cervical and anal cancers. All 27 participants w…

This study is testing if using two heat probes instead of one is a better way to treat early cervical changes and prevent cancer in women living with HIV. It will involve 300 women in Rwanda who have tested positive for HPV or a visual exam. The main goal is to see if the two-pro…

This study is testing if a drug called resmetirom can safely reduce harmful fat buildup in the livers of people who have both HIV and a related fatty liver disease (MASLD). About 120 adults with well-controlled HIV and confirmed MASLD will take either the real drug or a placebo p…

This study aims to improve depression treatment for young people (ages 15-24) living with HIV. Researchers will compare an enhanced version of a proven therapy program to a standard version across eight clinics. The goal is to see if the enhanced program leads to better, longer-l…

This study will test a brief telehealth counseling program delivered by nurses to people living with HIV in Tanzania who are experiencing thoughts of suicide. The goal is to see if three counseling sessions can reduce suicide risk and help people stay engaged with their HIV care.…

This study aims to test a new computer tool designed to help emergency room doctors identify patients at high risk for Hepatitis C and HIV. The tool uses a smart algorithm to analyze patient records and pop up an alert for doctors, suggesting they offer a screening test. Research…

This study will test a new, single rapid test device that can screen for four serious infections (HIV, hepatitis B, hepatitis C, and syphilis) at a prenatal clinic visit. It will involve 7,500 pregnant women in the Democratic Republic of Congo to see how well the new test works c…

This study aims to see if trained nurses working in local public health clinics can effectively provide a long-acting injection for HIV prevention. It will compare clinics where nurses follow a special protocol to start and manage this prevention method against clinics using thei…

This study is testing if using two heat probes instead of one is a better way to treat precancerous cervical cells in women living with HIV, who are at much higher risk for cervical cancer. Researchers in Kenya will compare the two approaches in 300 women to see which one is more…

This study aims to understand if ongoing inflammation in the body is connected to thinking and memory problems in teenagers living with HIV in Eswatini. Researchers will compare 50 HIV-positive teens with 30 HIV-negative teens, testing their brain function and measuring inflammat…

This study aims to understand how stimulant and multiple substance use affects heart inflammation and scarring in people living with HIV. Researchers will compare 400 participants with and without HIV using detailed heart MRI scans during a single visit. The goal is to gather kno…

This study is testing two simple smell-based activities to see if they are practical and acceptable for middle-aged and older adults living with HIV. Researchers want to know if regularly smelling scents at home for 8 weeks can improve participants' sense of smell and their cogni…