HEPATOCELLULAR CARCINOMA

This early-stage trial is testing a new drug called TB511, both by itself and in combination with the immunotherapy drug pembrolizumab (Keytruda). It aims to find a safe dose and see if it can shrink tumors in people with advanced solid cancers, including lung, prostate, colorect…

This early-stage study is testing a new type of cell therapy for adults with advanced solid tumors that have not responded to standard treatments. Doctors will collect a patient's own immune cells, genetically modify them in a lab to better recognize and attack their cancer, and …

This study looks back at whether combining multiple cancer treatments can shrink liver tumors enough to allow more patients to receive a liver transplant. Researchers will review medical records of 300 patients with advanced liver cancer who were initially considered ineligible f…

This study is testing if adding a drug called hydroxychloroquine to a standard liver cancer treatment (TACE) makes it work better. TACE works by cutting off a tumor's blood supply to starve it. Researchers think cancer cells survive this starvation by 'eating' themselves, a proce…

This study is testing a new drug called MRG006A, given together with existing immunotherapy and targeted therapy drugs, for people with advanced liver cancer that cannot be removed by surgery. The main goals are to find a safe and effective dose and to see if this combination can…

This study is testing a two-part treatment for liver cancer that cannot be surgically removed. Doctors will use tiny, drug-filled beads to block the tumor's blood supply and deliver chemotherapy directly, while patients also take an oral medication called Donafenib. The goal is t…

This small, early-stage study is testing whether adding a second immunotherapy drug helps control liver cancer after a targeted radiation treatment. About 20 patients with a specific type of liver cancer will receive radiation, then be assigned to get one of two different immunot…

This study is testing if adding a targeted radiation treatment (radiotherapy) to a two-drug therapy helps shrink liver tumors in patients whose cancer cannot be removed by surgery initially. The goal is to see if this combination can shrink the tumors enough to make surgery possi…

This study is testing a new, targeted radiation treatment for people with advanced liver cancer that has spread. The treatment uses a drug that seeks out cancer cells by attaching to a specific protein (PSMA) found on their blood vessels. Researchers want to see if this approach …

This study is testing if adding an experimental drug called GKL-006 to a standard liver cancer treatment (TACE) is more effective and safe. It will involve about 48 adults with advanced liver cancer that cannot be removed by surgery. The main goal is to see if the combination shr…

This study looks back at medical records to see if getting a COVID mRNA vaccine shortly before starting immunotherapy helps people with advanced liver cancer. Researchers will analyze data from about 200 patients in Austria to check if vaccinated patients had better treatment res…

This study is testing whether adding a drug called gecacitinib to two other cancer drugs (donafenib and a PD-1 inhibitor) can help control advanced liver cancer that has started growing again after initial immunotherapy. It will enroll 35 adults to see if this combination is safe…

This study looks back at medical records to see if a combination of three types of treatment can help people with liver cancer that cannot be removed by surgery. The goal is to see if this approach can shrink tumors enough so that surgery becomes an option later. It will compare …

This study is testing a combination treatment for people with advanced liver cancer that cannot be removed by surgery. It combines a procedure that delivers chemotherapy directly to the liver tumor with two drugs that help the immune system fight cancer and block tumor blood supp…

This is a first-in-human study testing a new oral drug called ACC-1898 in adults with advanced solid tumors who have run out of standard treatment options. The main goals are to find a safe dose and understand how the body processes the drug. Researchers will also look for early …

This study is for adults with advanced liver cancer that cannot be removed by surgery. It compares two different drug combinations, both given alongside a standard procedure called TACE. The goal is to see which combination helps patients live longer and control their cancer bett…

This study is testing a treatment that uses both freezing and heating to destroy liver tumors. It aims to see if this method is safe, controls the cancer, and triggers the body's own immune system to fight the disease. The trial will involve 120 patients with primary liver cancer…

This study is testing a targeted radiation treatment for people with early-stage liver cancer that cannot be removed by surgery. Doctors will inject tiny radioactive beads directly into the blood vessels feeding the tumor to deliver a high dose of radiation. The main goals are to…

This study is for people with advanced liver cancer who are already receiving durvalumab after initial treatment with tremelimumab and durvalumab. Researchers want to see if adding an experimental oral drug called zanzalintinib to the ongoing durvalumab treatment helps people liv…

This study is testing a new type of ultrasound scan to see if it can accurately tell whether a liver cancer treatment has worked. It will involve 200 adults who have had a heat-based treatment to destroy small liver tumors. The goal is to see if this safer, radiation-free scan ca…

This study is testing whether adding a drug called nanocrystalline megestrol acetate to standard liver cancer treatment can help patients who are experiencing severe, disease-related weight loss and poor appetite. The goal is to see if this combination helps people eat better and…

This study aims to understand liver cancer better by comparing advanced MRI scans in two groups: people with untreated liver cancer and healthy volunteers. It uses a special MRI machine to take detailed pictures of the liver. The goal is to see if these new scan types can reveal …