New combo therapy aims to shrink untreatable liver tumors

NCT ID NCT07180459

Not yet recruiting Disease control Sponsor: Xuhua Duan Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests a new approach for people with liver cancer that cannot be removed by surgery. Doctors will use tiny drug-coated beads to block blood flow to the tumor (a procedure called TACE) along with a targeted pill called Donafenib. The goal is to see if this combination can shrink tumors and help patients live longer. About 118 participants will be enrolled, and the study will track how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Donafenib (a targeted cancer drug) and drug-loaded microspheres (tiny beads that deliver chemotherapy directly to the tumor)
What this could lead to: If it works, this could offer a more effective way to control liver cancer that cannot be removed by surgery, potentially extending life and delaying tumor growth.
What could go wrong: This is an early, single-arm observational study with no comparison group, so results may not be definitive. The combination therapy also carries risks like liver damage, bleeding, or side effects from the drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

carcinoma hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA HEPATOCELLULAR CARCINOMA

Contacts and locations

Locations

Deng zhou People's Hospital

Nanyang, Henan, China
First People's Hospital of Shangqiu

Shangqiu, Henan, China
Huai He Hospital of Henan University

Kaifeng, Henan, China
Jiangxi Provincial People's Hospitail

Nanchang, Jiangxi, China
Luo He Central Hospital

Luohe, Henan, China
Luo Yang Central Hospital

Luoyang, Henan, China
People's Hospital of Kaiyang County

Guiyang, Guizhou, China
Second People's Hospital of Jiaozuo

Jiaozuo, China
The Second Affiliated Hospital of Hainan Medical Universsity

Haikou, Hainan, China
Zhou Kou Central Hospital

Zhoukou, Henan, China

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